2016 American Transplant Congress
Conditional Deletion of mTOR in Myeloid Cells Inhibits Chronic Allograft Rejection – A Novel Role for Macrophages in Transplant Vasculopathy.
Most transplants eventually lost to chronic rejection under potent immunosuppression therapies where activation of innate immunity is suspected to play a major role in graft…2016 American Transplant Congress
Impact of Early Hospital Readmission Following Simultaneous Pancreas Kidney Transplantation.
Surgery, Johns Hopkins University, School of Medicine, Baltimore, MD.
BACKGROUND: Our group recently demonstrated that 54% of simultaneous pancreas kidney (SPK) recipients experience early hospital readmission (EHR). It is unknown whether EHR following SPK…2016 American Transplant Congress
Prolongation of Graft Survival by Anti-TIM1 Is Specifically Mediated by IL-10+ Bregs and Is Not Dependent on IL-35 or Plasma Cell Differentiation.
In B cell-deficient mice, prolonged islet allograft survival (GS) mediated by anti-TIM1 depends on transfer of IL-10 competent B cells. However, such regulatory B cells…2016 American Transplant Congress
Lymph Node Stromal Laminins Differentially Regulate T Cell Immunity and Tolerance.
University of Maryland, Baltimore, MD.
Background:Our recent work demonstrated that laminins α4β1γ1 and α5β1γ1, components of the lymph node (LN) stroma, are differentially regulated. Tolerance is associated with relatively higher…2016 American Transplant Congress
Everolimus in Combination with Reduced Dose Tacrolimus Is Effective as a Prophylaxis of Acute Rejection in Low-to-Moderate Immunologic Risk De Novo Kidney Transplantation Patients.
The US92 study determined whether, in de novo renal transplant patients (pts), concentration-controlled everolimus (EVR) with reduced dose tacrolimus (RTAC) is non-inferior compared to CellCept®…2016 American Transplant Congress
Graft Outcomes in Pediatric Kidney Transplants Are Better with Laparoscopic Donor Nephrectomy and High Volume Centers.
1Abdominal Organ Transplantation, OHSU, Portland, OR; 2Urology, OHSU, Portland, OR.
Purpose Initial reports for pediatric kidney recipients suggested superior outcomes for open donor (ODN) compared to laparoscopic donor nephrectomy (LDN). Current outcomes based on donor…2016 American Transplant Congress
Hypothermic Machine Perfusion Is Also Beneficial for Deceased Donor Kidneys When Cold Ischemic Time Is Short and a Short Cold Ischemic Time Is Also Beneficial When Kidneys Are Machine Perfused.
IntroductionHypothermic machine perfusion (HMP) of deceased donor kidneys is associated with better outcome compared to static cold storage (SCS). It is generally assumed that HMP…2016 American Transplant Congress
Profiling Immunologic Risk for Acute Rejection in Liver Transplantation: Recipient Age Is a Robust Risk Factor.
Profiling the immunologic risk for acute rejection in liver transplantation (OLT) may allow for selection immunosuppression (IS) target ranges appropriate to risk levels, all with…2016 American Transplant Congress
Pre-Transplant Bariatric Surgery and One-Year Graft Loss Risk in Kidney Transplants.
Background: Several centers recommend bariatric surgery (BS) pre-transplantation (pre-Tx) with arbitrary BMI cutoffs. The effects of BS on Tx outcome are unclear. We studied the…2016 American Transplant Congress
Initial Experience Treating Hepatitis C Positive Kidney Transplant Recipients with Non-Interferon-Containing Regimens: Successes and Challenges.
Weill Cornell Medical College, New York, NY.
Historically, treatment of hepatitis C virus (HCV) infection with interferon-based regimens after kidney transplantation has been associated with risk of rejection & graft loss. Direct…
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