Am J Transplant, Volume 16, Suppl 3 Archives - Page 109 of 180 - ATC Abstracts

2016 American Transplant Congress
Tacrolimus (Tac), Rather Than Cyclosporine (CsA), Interacts with Insulin Resistance (IR) to Alter Key Transcription Factors for β-Cell Identity & Function without Altering NFAT Localization.
J. Triñanes,¹ A. Rodriguez,² E. de Koning,¹ J. de Fijter,¹ F. Carlotti,¹ A. Torres,² A. de Vries,¹ E. Porrini.²
¹Nephrology, Leiden University Medical Center, Leiden, Netherlands; ²CIBICAN, University of La Laguna, Tenerife, Spain.
Inhibiting the calcineurin(CN)/NFAT-pathway in β-cells may contribute to posttransplant diabetes. The presumed higher diabetogenicity of Tac is thought to owe to an IC50 for CN…
2016 American Transplant Congress
aPC Pretreatment of hEPCR-Expressing PAECs Attenuates Endothelial Cell Damage and Thrombosis.
C. Laird,¹ B. French,¹ D. Harris,¹ X. Chang,¹ D. Ayares,² R. Pierson,¹ A. Azimzadeh.¹
¹Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD; ²Revivicor, Inc, Blacksburg, VA.
IntroductionActivated Protein C (aPC), acting primarily through the human endothelial protein C receptor (hEPCR), mediates anti-thrombotic and anti-inflammatory cytoprotective effects in humans. We hypothesized that…
2016 American Transplant Congress
Clinical and Immunologic Assessments of Immune Responses in a Liver Transplant Patient with CD40L Deficiency and Hyper IgM Syndrome.
M. Tseng,¹ S. Ge,¹ R. Roberts,² C. Kuo,² J. Choi,¹ N. Nissen,¹ M. Chu,¹ I. Kim,¹ B. Shin,¹ M. Toyoda,¹ S. Jordan.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pediatrics & Immunology, UCLA, Los Angeles, CA.
Introduction: Monoclonal antibodies that disrupt CD40/CD40 ligand (CD40L) interactions are likely to have utility in human transplantation. However, the extent of the immunosuppressive effects of…
2016 American Transplant Congress
Risk Factors for Clinical Urinary Tract Infections in Kidney Transplant Recipients with Asymptomatic Bacteriuria.
S. Medani, M. Dorais, A. Tavares-Brum, H. Mawad, A. Duclos, C. Lemieux, A. Barama, H. Cardinal.
Centre Hospitalier de l'Université de Montréal, Montréal, Canada.
BackgroundThere is no clear consensus on whether asymptomatic bacteriuria (ABU) should be treated in kidney transplant recipients (KTRs). We sought to identify patient or episode…
2016 American Transplant Congress
Differential Effect of Delayed Graft Function (DGF) on Kidney Transplant Outcomes: When Does DGF Not Make a Difference?
M. Khan,¹ H. El-Hennawy,¹ A. Farney,¹ J. Rogers,¹ G. Orlando,¹ A. Reeves-Daniel,² A. Palanisamy,² M. Gautreaux,³ S. Iskandar,³ W. Doares,⁴ S. Kaczmorski,⁴ R. Stratta.¹
¹Surgery, Wake Forest, Winston-Salem, NC; ²Internal Medicine, Wake Forest, Winston-Salem, NC; ³Pathology, Wake Forest, Winston-Salem, NC; ⁴Pharmacy, Wake Forest, Winston-Salem, NC.
Delayed graft function (DGF), defined as need for dialysis in 1st week following kidney transplant (KT), is an early surrogate marker of organ quality and…
2016 American Transplant Congress
Preservation of Alloreactive and Antiviral Immunity After Switch to Belatacept-Based Regimen After Kidney Transplantation.
J. Schaenman,¹ Y. Korin,² T. Sidwell,² V. Groysberg,² J. Gadzhyan,¹ E. Lum,¹ U. Reddy,¹ E. Huang,¹ T. Pham,¹ G. Danovitch,¹ E. Reed,² S. Bunnapradist.¹
¹Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; ²Department of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, CA.
Purpose: We set out to investigate the impact of switch from calcineurin inhibitor (CNI) to belatacept on T cell mediated allo- and EBV-specific immunity.Methods: We…
2016 American Transplant Congress
Unexpected Early Calcineurin Inhibitor Nephrotoxicity in Pediatric Kidney Transplant Recipients.
M. Yanik,¹ R. Mannon,² M. Seifert.¹
¹Pediatrics, University of Alabama at Birmingham, Birmingham, AL; ²Medicine, University of Alabama at Birmingham, Birmingham, AL.
Background: Calcineurin inhibitors effectively suppress the recipient immune response and facilitate early success in kidney transplantation. However, these drugs are potent nephrotoxins and contribute to…
2016 American Transplant Congress
Early Tacrolimus Exposure in Patients Treated De Novo with Once-Daily Tacrolimus After Liver Transplantation: Relationship with Acute Rejection and Long-Term Outcome.
M. Gastaca, A. Valdivieso, J. Bustamante, P. Ruiz, J. Fernandez, A. Ventoso, M. Testillano, I. Palomares, M. Prieto, P. Salvador, A. Matarranz, M. Suarez, J. Ortiz de Urbina.
Liver Transplantation Unit, Cruces University Hospital, Bilbao, Vizcaya, Spain.
AIM: The aim of our study was to define the possible influence of early tacrolimus exposure on long-term outcomes in patients treated with de novo…
2016 American Transplant Congress
Cost-Effectiveness of Machine Perfusion Use After Long Cold Ischemic Time in a Kidney Transplantation Program.
A. Matos, D. Malheiros, S. Morgado, L. Requiao-Moura, M. Borrelli, M. Nogueira, M. Durao, E. Tonato, A. Pacheco-Silva.
Renal Transplantation Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
In Brazil the incidence of DGF is very high (60-70%) mainly due to an inadequate care of the donors and long cold ischemia time. This…
2016 American Transplant Congress
Long-Term vs Short-Term Valganciclovir Prophylaxis Use for Cytomegalovirus and Epstein-Barr Virus Infections in Pediatric Living Related Liver Transplantation.
T. Ueno,¹ H. Yamanaka,¹ Y. Takama,¹ N. Tanaka,¹ Y. Tazuke,¹ K. Bessho,² H. Okuyama.¹
¹Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan; ²Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan.
[Purpose] Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections are the most important viral infections in pediatric patients with transplant. Valganciclovir (VGCV) has been used as…