ATC Abstracts

American Transplant Congress abstracts

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  • 2016 American Transplant Congress

    Development and Validation of a Molecular Microscope Diagnostic System (MMDx) for Heart Transplant Biopsies.

    P. Halloran,1 D. Kim,1 A. Loupy,2 J.-P. Duong Van-Huyen,2 P. Bruneval,3 L. Potena,4 O. Leone,4 J. Reeve.1

    1University of Alberta, Edmonton, Canada; 2Necker Hospital, Paris, France; 3Hopitaux de Paris, Paris, France; 4Bologna University, Bologna, Italy.

    The diagnosis of heart transplant rejection by histology in endomyocardial biopsies (EMB) is challenging. A molecular system (MMDx) has been developed to assess both T…
  • 2016 American Transplant Congress

    Pancreas After Islet Transplantation – A Successful Treatment Option After a Failed Islet Transplant.

    R. Gruessner, N. Ozden, V. Whittaker, V. Aggarwal, A. Gruessner.

    Department of Surgery, SUNY Upstate Medical University, Syracuse, NY.

    Introduction: Pancreas after islet (PAI) transplantation (tx) is a treatment option for patients seeking insulin independence through a whole organ transplant after a previous, failed…
  • 2016 American Transplant Congress

    Provider Attitudes Toward Shared Mobile Decision Aid Utilized Among Patients Evaluated for Kidney Transplantation: iChoose Kidney Randomized Trial.

    M. Basu,1 S. Pastan,1 S. Mohan,2 M. Wolf,3 J. Friedewald,3 D. Ladner,3 K. Smith,1 L. McPherson,1 A. Russell,3 M. Chiles,2 R. Patzer.1

    1Emory University, Atlanta, GA; 2Columbia University, New York, NY; 3Northwestern University, Evanston, IL.

    Introduction: Although kidney transplantation (KTx) provides significant survival advantage over long-term dialysis, many end stage renal disease (ESRD) patients are not educated about KTx options.…
  • 2016 American Transplant Congress

    A Retrospective Study of Simultaneous Bilateral Nephrectomies and Renal Transplantation in Recipients with Polycystic Kidney Disease.

    E. Grodstein, D. Kaufman.

    Department of Surgery, Division of Transplantation, University of Wisconsin, Madison, WI.

    Background: Many strategies regarding timing of native nephrectomies exist for patients with symptomatic polycystic kidney disease (PCKD). We hypothesize that the timing of bilateral nephrectomies…
  • 2016 American Transplant Congress

    Impact of Induction Therapy on Cardiovascular Events in Kidney Transplant Recipients.

    S. Sandal,1,2 S. Bae,2 A. Massie,2 M. Cantarovich,1 D. Segev.2

    1MUHC, Montreal, Canada; 2JHU, Baltimore.

    Cardiovascular events (CVE) are one of leading causes of mortality in kidney transplant (KT) recipients and ATG use is reported as a risk factor. We…
  • 2016 American Transplant Congress

    Initial Experience with Donor Specific Tregs in Kidney Transplantation.

    J. Markmann,1 E. Guinan,2 E. Geissler,3 G. Cole,2 S. Germana,1 J. Kim,1 B. Sawitzki.4

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; 2Hematology/Oncology, Dana-Farber Cancer Center, Boston, MA; 3Surgery, Universitätsklinikum Regensburg, Regensburg, Germany; 4Institute of Medical Immunology, Charite Universitätsmedizin, Berlin, Germany.

    Systematic multicenter clinical evaluation of regulatory cells is being conducted by the EU supported ONE Study trial in which each site is administering a different…
  • 2016 American Transplant Congress

    A Users Guide to Maximizing Utility and Outcome in >70 Year Old Donors.

    K. Halazun, E. Przybyszewski, B. Samstein, E. Verna, A. Fox, R. Brown, J. Emond.

    Liver Transplant & HPB Surgery, Weill Cornell Medical College, NY, NY.

    Background Among 10 million stroke fatalities in the US since 2002, donated livers were recovered from 28,313. Unfortunately, only 2,402 livers were yielded from 7.5…
  • 2016 American Transplant Congress

    αLFA-1 Monotherapy Induced Tolerance Is Dependent on Indirect CD8 T-Cells and Augments a Population of CD8 Cells with a Suppressor Phenotype.

    R. Plenter,1 M. Coulombe,2 T. Grazia,1 R. Gill,2 M. Zamora,1 B. Pietra.3

    1Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, CO; 2Department of Surgery, University of Colorado, Aurora, CO; 3Division of Pediatric Cardiology, University of Florida, Gainesville, FL.

    We sought to investigate some of the requirements for tolerance induction to cardiac allografts utilizing αLFA-1 mAb monotherapy. Having previously demonstrated that CD8 T-cells are…
  • 2016 American Transplant Congress

    Abrogating Donor-Derived Myd88 Signaling Impairs the Recruitment of Recipient Neutrophils and CD8 T Cells into Lung Allografts in Mice.

    Z. Zheng,1 J.-J. Wang,1 X. Yeap,1 X. Kang,1 Y. Xie,1 X. Luo,2 Z. Zhang.1

    1Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; 2Division of Nephrology and Hypertension, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.

    Objectives: Transplant ischemia reperfusion injury (IRI) mediated primary graft dysfunction (PGD) remains the predominant cause of short- and long-term graft loss in lung transplantation. This…
  • 2016 American Transplant Congress

    miR-21 in Chronic Allograft Vasculopathy.

    V. Usuelli,1 M. Ben Nasr,1,2 F. D'Addio,1,2 L. Kaifeng,2 L. Borgese,3 L. Potena,3 A. Solini,4 C. Rossi,4 A. Secchi,1 D. Corradi,5 N. Chau,6 P. Fiorina.1,2

    1Ospedale San Raffaele, Milano, Italy; 2Boston Children's Hospital, Boston; 3University of Bologna, Bologna, Italy; 4University of Pisa, Pisa, Italy; 5University of Parma, Parma, Italy; 6Regulus Therapeutics Inc, San Diego.

    Background. Heart transplantation is the most effective therapy to prolong life expectancy in patients with end-stage heart failure. However, despite much progress in the field,…
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