Treading the Paradigm Shift: A Single Center Comparative Study of Outcomes Between Pre-Emptive and Early Kidney Transplant with Non Pre-Emptive Kidney Transplant Recipients Innational Kidney and Transplant Institute
Organ Transplantation and Vascular Surgery, National Kidney and Transplant Institute, Quezon City, Philippines
Meeting: 2022 American Transplant Congress
Abstract number: 1712
Keywords: Biopsy, Graft failure, Graft function, Kidney transplantation
Topic: Clinical Science » Kidney » 42 - Kidney Living Donor: Selection
Session Information
Session Name: Kidney Living Donor: Selection
Session Type: Poster Abstract
Date: Tuesday, June 7, 2022
Session Time: 7:00pm-8:00pm
Presentation Time: 7:00pm-8:00pm
Location: Hynes Halls C & D
*Purpose: To compare the 3-year outcome of pre-emptive and early kidney transplant recipients versus non pre-emptive recipients in our institution from January 2013 to December 2017.
*Methods: This is a retrospective cohort study on patients who underwent living donor kidney transplantation from January 1, 2013 to December 31, 2017 at NKTI. Data were collected from the hospital’s medical records section. Patients were divided into three groups pre-emptive KT, early KT, and non pre-emptive KT. Patient demographics, delayed graft function, allograft rejection, graft loss and patient mortality were compared between the three groups using appropriate statistical tool.
*Results: There were 715 subjects included, 102 (14.3%) under pre-emptive KT, 162 (22.3%) early KT, and 452 (63.2%) non pre-emptive KT. The patients were between 18-60 years old, mean age of 41.37 for pre-emptive, 39.95 for early KT, and 39.07 for non pre-emptive groups. Sixty six percent of all subjects were males. Chronic glomerulonephritis is the major cause of renal disease in 55% of the subjects. Waiting time between onset of dialysis and kidney transplantation is from 0.25 to 96 months. Average time on dialysis were 3.35 months for early KT and 20.71 months for non pre-emptive group. Delayed graft function occurred in 2%, 2.5% and 3.9% of pre-emptive, early KT and non pre-emptive KT groups, respectively. The incidence of biopsy proven rejections was not statistically significant across the three groups with the p-value of 0.179. Non pre-emptive KT recipients had higher 3-year graft loss (4.6%) and 3-year patient mortality (4.2%) as compared to pre-emptive (2% graft loss and mortality) and early KT (1.9% graft loss and 1.2% patient mortality).
*Conclusions: Pre-emptive and early kidney transplant recipients have lower incidence of delayed graft function and biopsy proven acute or chronic rejections. Likewise, there is increasing trend in graft loss and patient mortality with the non pre-emptive group, increasing proportionally as the years of follow up increases.
To cite this abstract in AMA style:
Go EU, Baloloy L. Treading the Paradigm Shift: A Single Center Comparative Study of Outcomes Between Pre-Emptive and Early Kidney Transplant with Non Pre-Emptive Kidney Transplant Recipients Innational Kidney and Transplant Institute [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/treading-the-paradigm-shift-a-single-center-comparative-study-of-outcomes-between-pre-emptive-and-early-kidney-transplant-with-non-pre-emptive-kidney-transplant-recipients-innational-kidney-and-trans/. Accessed May 16, 2025.« Back to 2022 American Transplant Congress