Date: Sunday, June 2, 2019
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: The predictive capacity of previous pre-transplant histologic scoring systems for short-term and long-term graft function in kidney transplantation has not been adequately validated.
*Methods: Deceased donor kidney recipients transplanted in a single center between 2014 and 2018 who underwent a pre-transplant donor kidney allograft biopsy were included in this study (N=181). The formalin-fixed paraffin-embedded biopsies were rescored according to the existing 8 scoring systems (Remuzzi, Pirani, MAPI, Total Chronic Banff Score, CADI, Banff donor score, DDS, Ugarte score).
*Results: The average age of recipients and donors were 43±14 and 34±14 years old. The follow-up time was 1.12 year on average. All scoring systems presented a trend that biopsies with high score increased the risk of DGF and death-censored graft survival and reduced 1-year eGFR. Ugarte and Banff donor scoring system had a good predictive capacity for DGF.
*Conclusions: Both Ugarte and Banff donor scoring system had a good predictive capacity for short-term graft function in kidney transplantation. It could be explained by the inclusion of acute tubular injury as their assessment component.
|Scorin g system||DGF (OR)||Death-censored graft survival (HR)||1-year eGFR (ml/min*1.73m2)|
|Remuzzi(severe & moderate vs mild)||2.217||3.778||-7.677|
|MAPI(severe & moderate vs mild)||1.524||–||-12.506|
|DDS(severe & moderate vs mild)||1.458||3.394||-8.099|
|Ugarte score(severe & mild vs no)||3.835*||2.095||-9.523|
|Total Chronic Banff Score(severe & moderate vs mild)||1.636||1.431||-8.738|
|CADI(severe & moderate vs mild)||1.425||1.274||-8.738|
|Banff Donor Score(severe & moderate vs mild)||2.122*||1.737||-7.656|
To cite this abstract in AMA style:Zhang H, Liu L, Yang S, Chen W, Chen X, Li Y, Wang C. The Predictive Value Of Pre-transplant Biopsies For Short-term And Long-term Graft Function In Kidney Transplantation [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/the-predictive-value-of-pre-transplant-biopsies-for-short-term-and-long-term-graft-function-in-kidney-transplantation/. Accessed October 27, 2020.
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