The Importance of Caveolin-1 Immunohistochemical Staining for BK Nephropathy Seen after Kidney Transplantation
1Medical Biology, Istanbul University School of Medicine, Istanbul, Turkey, 2Pathology, Istanbul University School of Medicine, Istanbul, Turkey, 3Nephrology, Istanbul University School of Medicine, Istanbul, Turkey
Meeting: 2020 American Transplant Congress
Abstract number: B-201
Keywords: Kidney transplantation, Nephropathy, Polyma virus
Session Information
Session Name: Poster Session B: Kidney: Polyoma
Session Type: Poster Session
Date: Saturday, May 30, 2020
Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
Location: Virtual
*Purpose: To understand the importance of molecular expression of Caveolin-1 in BKV nephropathy seen after kidney transplantion.
*Methods: The kidney transplant patients who had a graft biopsy due to BK virus viremia were divided into two groups according to the BK virus nephropathy found in kidney biopsies (Group I: Viremia +, Nephropathy + / Group II: Viremia+,Nephropathy-). Immunohistochemical staining of the biopsy specimens with anti-caveolin-1 immunoglobulin were performed and compared between the two groups.
*Results: Immunohistochemical staining of the 31 specimens with anti-caveolin-1 immunoglobulin revealed statistically significant difference between group-I and group-II (Table-1)(Figure-1) . The number of the specimens stained with anti-caveolin-1 was less in group I (p=0.0024)
*Conclusions: Variations in the expression paterns of Caveolin-1 molecule may have a protective effect in the kidney transplant patients with BK virus viremia.
Anti-Caveolin-1 positive | Anti-Caveolin-1 negative | Total | |
Group I | 2 | 10 | 12 |
Group II | 15 | 4 | 19 |
Total | 17 | 14 | 31 |
To cite this abstract in AMA style:
Arpali E, Sunnetcioglu E, Özlük Y, Turkmen A, Oğuz FS. The Importance of Caveolin-1 Immunohistochemical Staining for BK Nephropathy Seen after Kidney Transplantation [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/the-importance-of-caveolin-1-immunohistochemical-staining-for-bk-nephropathy-seen-after-kidney-transplantation/. Accessed October 6, 2024.« Back to 2020 American Transplant Congress