Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
*Purpose: To understand the importance of molecular expression of Caveolin-1 in BKV nephropathy seen after kidney transplantion.
*Methods: The kidney transplant patients who had a graft biopsy due to BK virus viremia were divided into two groups according to the BK virus nephropathy found in kidney biopsies (Group I: Viremia +, Nephropathy + / Group II: Viremia+,Nephropathy-). Immunohistochemical staining of the biopsy specimens with anti-caveolin-1 immunoglobulin were performed and compared between the two groups.
*Results: Immunohistochemical staining of the 31 specimens with anti-caveolin-1 immunoglobulin revealed statistically significant difference between group-I and group-II (Table-1)(Figure-1) . The number of the specimens stained with anti-caveolin-1 was less in group I (p=0.0024)
*Conclusions: Variations in the expression paterns of Caveolin-1 molecule may have a protective effect in the kidney transplant patients with BK virus viremia.
|Anti-Caveolin-1 positive||Anti-Caveolin-1 negative||Total|
To cite this abstract in AMA style:Arpali E, Sunnetcioglu E, Özlük Y, Turkmen A, Oğuz FS. The Importance of Caveolin-1 Immunohistochemical Staining for BK Nephropathy Seen after Kidney Transplantation [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/the-importance-of-caveolin-1-immunohistochemical-staining-for-bk-nephropathy-seen-after-kidney-transplantation/. Accessed October 26, 2020.
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