2022 American Transplant Congress
Genotype and Phenotype Analysis and the Transplantation Strategy in Children with Uremia Caused by Nephronophthisis
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Nephronophthisis- related ciliopathies(NPHP- RC), as an important cause of children's end-stage renal disease(ESRD), has strong genotype and phenotype heterogeneity, and the transplantation strategy of…2022 American Transplant Congress
Multiplexed Droplet Single-Cell Sequencing (mux-seq) Identifies Novel Cell States in Renal Allograft Rejection
*Purpose: Maintenance of systemic homeostasis by kidney requires the coordinated response of diverse cell types. Use of single-cell RNA sequencing (scRNAseq) for patient samples remains…2022 American Transplant Congress
The Impact of Neutralizing Antibodies on Polyomavirus Infections in Mice
Pathology and Laboratory Medicine, UNC Chapel Hill School of Medicine, Chapel Hill, NC
*Purpose: Definitive polyomavirus nephropathy (PyVN) affects kidney transplants and impacts allograft function and survival. Data suggest that neutralizing PyV strain specific antibodies can attenuate and…2022 American Transplant Congress
Novel Drug Target Identified for Reversal of Renal Tubular Injury
*Purpose: Understanding the unique susceptibility of the human kidney tubule to oxidative cell stress and to identify compounds to support reversal of renal tubular damage.*Methods:…2022 American Transplant Congress
Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation
Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: The natural course of diabetic donors on the outcome of kidney transplantation (KT) is controversial. The aim of this study was to analyze the…2022 American Transplant Congress
RBBP7 as a Novel Biomarker for the Molecular Diagnosis of BK Virus-Associated Nephropathy
Department of Urology, Beijing Chaoyang Hospital, Beijing, China
*Purpose: BK virus-associated nephropathy (BKVN) remains a major infectious complication of kidney transplantation, and its histologic appearance can mimic rejection, leading to a diagnostic dilemma…2022 American Transplant Congress
Single-cell Transcriptomic Analysis Of Peripheral Blood Reveals The Disparate Subsets Of Innate Immune Cells In Kidney Transplant Recipient With BK Virus Infection
*Purpose: BK virus (BKV) infection is a common problem in kidney transplant recipients receiving immunosuppressive therapy, resulting in a serious complications including BKV-associated nephropathy and…2021 American Transplant Congress
Defining the Characteristics and Graft Outcomes of Kidney Transplant Recipients with Elevated Plasma Oxalate Level Not Due to Primary Hyperoxaluria
*Purpose: Patients with elevated systemic oxalate burden due to enteric etiologies are at increased risk for calcium oxalate deposition causing ESRD. The objective of this…2021 American Transplant Congress
PLA2R Status and Antibody Mediated Rejection in Kidney Transplant with Membranous Nephropathy
*Purpose: Membranous nephropathy (MN) in transplanted kidney is categorized as de novo or recurrent disease. This immune complex glomerulopathy presents with varying levels of proteinuria,…2021 American Transplant Congress
Leflunomide Therapy for Treatment of Bk Viremia in Pediatric Kidney Transplant Recipients
*Purpose: BK viremia (BKV) after kidney transplantation (KT) poses significant risk for BK virus-associated nephropathy (BKVN) and impacts graft survival. Conventional treatment involves reduction of…
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