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The Importance of Caveolin-1 Immunohistochemical Staining for BK Nephropathy Seen after Kidney Transplantation

E. Arpali1, E. Sunnetcioglu2, Y. Özlük2, A. Turkmen3, F. S. Oğuz1

1Medical Biology, Istanbul University School of Medicine, Istanbul, Turkey, 2Pathology, Istanbul University School of Medicine, Istanbul, Turkey, 3Nephrology, Istanbul University School of Medicine, Istanbul, Turkey

Meeting: 2020 American Transplant Congress

Abstract number: B-201

Keywords: Kidney transplantation, Nephropathy, Polyma virus

Session Information

Session Name: Poster Session B: Kidney: Polyoma

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: To understand the importance of molecular expression of Caveolin-1 in BKV nephropathy seen after kidney transplantion.

*Methods: The kidney transplant patients who had a graft biopsy due to BK virus viremia were divided into two groups according to the BK virus nephropathy found in kidney biopsies (Group I: Viremia +, Nephropathy + / Group II: Viremia+,Nephropathy-). Immunohistochemical staining of the biopsy specimens with anti-caveolin-1 immunoglobulin were performed and compared between the two groups.

*Results: Immunohistochemical staining of the 31 specimens with anti-caveolin-1 immunoglobulin revealed statistically significant difference between group-I and group-II (Table-1)(Figure-1) . The number of the specimens stained with anti-caveolin-1 was less in group I (p=0.0024)

*Conclusions: Variations in the expression paterns of Caveolin-1 molecule may have a protective effect in the kidney transplant patients with BK virus viremia.

Immunohistochemical Staining with Anti-caveolin-1Antibody for the Group I and Group II
Anti-Caveolin-1 positive Anti-Caveolin-1 negative Total
Group I 2 10 12
Group II 15 4 19
Total 17 14 31

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To cite this abstract in AMA style:

Arpali E, Sunnetcioglu E, Özlük Y, Turkmen A, Oğuz FS. The Importance of Caveolin-1 Immunohistochemical Staining for BK Nephropathy Seen after Kidney Transplantation [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/the-importance-of-caveolin-1-immunohistochemical-staining-for-bk-nephropathy-seen-after-kidney-transplantation/. Accessed May 11, 2025.

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