ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Dosage"

  • 2020 American Transplant Congress

    Assessment of Time to Therapeutic Tacrolimus Levels Following Renal Transplantation in a Non-Weight-Based Dosing Model

    J. Banbury1, A. Dodson1, C. Lin2, K. Gutierrez1

    1University of Alabama at Birmingham Hospital, Birmingham, AL, 2Center for Clinical and Translational Science, University of Alabama at Birmingham, Birmingham, AL

    *Purpose: The optimal initial dose for tacrolimus (TAC) after renal transplant (RT) remains controversial with limited evidence comparing weight-based and conservative strategies. Recent literature suggests…
  • 2020 American Transplant Congress

    Less Bleeding Associated with Apixaban versus Other Direct Acting Oral Anticoagulation in Solid Organ Transplant Recipients

    M. Thornberg1, J. Scheffert1, D. Jennings2, J. Hedvat1, N. Lange1, H. Robbins3, D. Salerno1

    1NewYork-Presbyterian Hospital, Department of Pharmacy, New York, NY, 2Long Island University School of Pharmacy, Brooklyn, NY, 3Columbia Irving University Medical Center, Department of Medicine, New York, NY

    *Purpose: Owing to their fixed dosing and favorable drug interaction profiles, direct acting oral anticoagulants (DOACs) have supplanted warfarin as the standard of care for…
  • 2020 American Transplant Congress

    A Single Centre Experience of Conversion from Immediate Release Tacrolimus (IR-tac) to Extended Release Envarsus

    S. Chong1, E. Kent2, C. Beligaswatta2, P. Gudka2, C. Magee2, M. Harber2, R. Motallebzadeh1, G. Jones2

    1Centre for Transplantation, Department of Renal Medicine, University College London & Royal Free London NHS Foundation Trust​, London, United Kingdom, 2Department of Renal Medicine, University College London & Royal Free London NHS Foundation Trust​, London, United Kingdom

    *Purpose: IR-Tac is first line maintenance immunosuppression in kidney transplant recipients. Its rapid absorption of 1-2 hours can lead to peak levels (Tmax ) within…
  • 2020 American Transplant Congress

    Impact of Donor Race on Tacrolimus Dose Requirement for Liver Transplant Recipients

    N. Nesselhauf1, S. January1, J. Hagopian1, K. Progar1, A. Khan2

    1Pharmacy, Barnes-Jewish Hospital, St. Louis, MO, 2Surgery, Washington University School of Medicine, St. Louis, MO

    *Purpose: It is well described that there is interpatient variability in tacrolimus dose requirements among transplant recipients. CYP3A5 plays a role in this variability. Black…
  • 2020 American Transplant Congress

    A Novel Formula to Determine Optimal Immunosuppression in Renal Transplant Recipients Treated with Tacrolimus and Mycophenolate Mofetil: Towards Individualized Immunosuppression

    O. Pankewycz1, M. Laftavi1, E. Onan2, D. Rucker1, D. Wang1, K. Bhuta1, R. Gruessner3, A. Gruessner3

    1SUNY, Upstate Medical University, Syracuse, NY, 2Cukurova University, Adana, Turkey, 3SUNY, Downstate Medical University, New York, NY

    *Purpose: Tacrolimus (TAC) and mycophenolic acid (MPA) remain the most commonly used drug combination for kidney transplant immunosuppression. Adequate drug dosing is challenging due to…
  • 2020 American Transplant Congress

    Late Intra-Patient Tacrolimus Variability Predicts De Novo Donor-Specific Antibody and Graft Loss

    J. Lee1, E. Kim1, S. Yang2, S. Kim1, H. Choi3, B. Kim4, M. Ju5, M. Kim2, S. Kim2, Y. Kim2, K. Huh2

    1Department of Transplantation Surgery, Severance Hospital, Seoul, Korea, Republic of, 2Department of Transplantation Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, 3Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, 4Department of Internal Medicine, Severance Hospital, Seoul, Korea, Republic of, 5Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of

    *Purpose: Intra-patient variability (IPV) of tacrolimus level has been associated with poor outcomes after kidney transplantation. However, these findings were limited mainly to measurements early…
  • 2020 American Transplant Congress

    Dosing and Outcomes of Conversion to Extended-Release Tacrolimus in Heart and Lung Transplant Recipients

    C. Doligalski1, K. Walter1, P. Chang2, L. J. Lobo2

    1University of North Carolina Medical Center, Chapel Hill, NC, 2Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC

    *Purpose: Extended release tacrolimus (LCP-Tac) is a novel once daily formulation with improved pharmacokinetic parameters compared to immediate release tacrolimus (IR-Tac). LCP-Tac use in renal…
  • 2020 American Transplant Congress

    De Novo Dosing of LCP-Tacrolimus Using Conservative Weight-Based Strategy Resulted in Supratherapeutic Trough Levels in Majority of Patients

    J. Dann, J. Geyston, M. Wassimi, K. Brayman, A. Doyle

    University of Virginia Health System, Charlottesville, VA

    *Purpose: Due to ongoing national drug shortages, our center transitioned to de novo use of LCP-tacrolimus (LCPT) in kidney transplant patients using a conservative dosing…
  • 2020 American Transplant Congress

    De Novo Dosing and Trough Attainment Trends of Extended-Release Tacrolimus in the Absence of Dose Adjustments

    M. J. Moritz1, D. R. Stevens2, U. Meier-Kriesche2, T. A. Horwedel2

    1Department of Surgery, Lehigh Valley Health Network, Allentown, PA, 2Veloxis Pharmaceuticals, Cary, NC

    *Purpose: Initial dosing of tacrolimus extended-release tablets (LCPT) was 0.17 mg/kg/day in the pivotal trial in de novo kidney transplant recipients. Dosing subsequent to the…
  • 2020 American Transplant Congress

    Safety and Efficacy of Valganciclovir for Cytomegalovirus Prophylaxis in Solid Organ Transplant Patients on Hemodialysis

    D. E. Ecabert, C. Pham, B. J. Pierce, W. L. Musick

    Houston Methodist Hospital, Houston, TX

    *Purpose: Cytomegalovirus (CMV) is the most common viral infection after solid organ transplant (SOT) and is associated with significant morbidity and mortality. Valganciclovir (VGCV) is…
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