2019 American Transplant Congress
Not All Poor Metabolizers Are Clinically Equal: Evaluating Weight-Based Tacrolimus Outcomes in CYP3A Loss of Function Variants
Vidant Medical Center - Transplant Services, Greenville, NC
*Purpose: CYP3A polymorphisms are an important pharmacotherapeutic consideration due to the extensive CYP metabolism of tacrolimus (TAC) and variable expression among different races. The CPIC…2019 American Transplant Congress
Dosing Requirements Of Astagraf Xl In African American Kidney Transplant Recipients Converted From Twice-daily Tacrolimus (aaaktrs)
Medical University of South Carolina, Charleston, SC
*Purpose: Pharmacokinetics from clinical studies demonstrated similar drug exposure (AUC) and correlation between trough (C0) and AUC between tacrolimus IR and Astagraf XL, which led…2019 American Transplant Congress
Efficacy of Filgrastim in Solid Organ Transplant Recipients
*Purpose: Neutropenia frequently occurs after solid organ transplantation (SOT) due to immunosuppression, antiviral prophylaxis, or viral infections. Immunosuppression reduction or antiviral prophylaxis minimization can lead…2019 American Transplant Congress
Association Between Cumulative Pre-transplant Amiodarone Dose And Post-transplant Outcomes After Heart Transplantation
*Purpose: Previous studies have demonstrated a correlation between pre-transplant amiodarone use and post-operative bradycardia, primary graft dysfunction, and mortality in heart transplant (HT) recipients; this…2019 American Transplant Congress
Neutralization of Interlukin-6 by ALD518-P18 (Murine Clazakizumab) Attenuates Donor Specific Antibody Responses in a Mouse Model of Allogeneic Sensitization: A Report of Dosage Finding Study
Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: Interleukin-6 (IL-6) is a proinflammatory cytokine involved in mediating both T-cell and B-cell responses in allograft rejection. In previous studies, we demonstrated that inhibition…2019 American Transplant Congress
Oral Ribavirin Therapy for Respiratory Syncytial Virus (RSV) in Lung Transplant Recipients: The Impact of Policy Implementation on Cost and Appropriate Use
Henry Ford Hospital, Detroit, MI
*Purpose: RSV is a leading cause of viral infections in lung transplant recipients and is associated with significant morbidity and mortality. While the role of…2019 American Transplant Congress
Use of an Ideal Body Weight-Based Rabbit Anti-Thymocyte Globulin Dosing Protocol in Kidney Transplant Recipients to Decrease Cost and Maintain Outcomes at a Large Academic Medical Center
1Pharmacy, Mayo Clinic, Rochester, MN, 2Transplantation Surgery, Mayo Clinic, Rochester, MN
*Purpose: This quality improvement study sought to assess if rejection post-transplant was increased following implementation of an ideal body weight (IBW)-based dosing protocol for patients…2019 American Transplant Congress
The Dry Weight Revealed!, What Transplanted Kidneys Teach Us about the (Dry Weight).
*Purpose: Volume overload in patients with ESRD/CKD V patients is associated with worse operative outcomes and potentially higher rate of delayed graft function, in addition…2019 American Transplant Congress
Time to First Therapeutic Tacrolimus Trough in Kidney Transplant Recipients: A Comparison of a Weight Based versus a Non-Weight Based Dosing Strategy
Ohio State Wexner Medical Center, Columbus, OH
*Purpose: Reaching a therapeutic tacrolimus (TAC) trough early post-kidney transplant is important in minimizing the risk of acute rejection. The aim of this study was…2019 American Transplant Congress
CURATE.AI: Personalized Liver Transplant Tacrolimus Dosing
*Purpose: Transplant immunosuppressive regimens include multiple drugs with varying pharmacokinetics, metabolic pathways, and drug-drug interactions. This study aimed to use CURATE.AI, an artificial intelligence platform,…
American Transplant Congress abstracts