ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Replicative Senescence and Arteriosclerosis After Kidney Transplantation.

K. De Vusser,1 D. Martens,2 E. Lerut,3 D. Kuypers,1 T. Nawrot,2 M. Naesens.1

1Department of Nephrology and Renal Transplantation, UZ Leuven, Leuven, Belgium
2Department of Imaging and Pathology, KULeuven, Leuven, Belgium
3Centre for Environmental Sciences, U Hasselt, Hasselt, Belgium.

Meeting: 2016 American Transplant Congress

Abstract number: B219

Keywords: Age factors, Arteriosclerosis, Graft survival, Protocol biopsy

Session Information

Date: Sunday, June 12, 2016

Session Name: Poster Session B: Kidney: Cardiovascular and Metabolic

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Halls C&D

Related Abstracts
  • Mitochondrial Feedback Mechanisms in Kidney Cell Senescence
  • Discrepancy between Biological Age and Calendar Age: A Large Histology Study in Implantation Biopsies, The

Background

Replicative senescence is associated with telomere shortening. In native kidneys, obtained prior to transplantation, we recently described and validated a significant association between shorter intrarenal telomere length and renal arteriosclerosis. After renal transplantation, animal experiments suggested that ischemia-reperfusion injury, acute rejection episodes, and cytomegalovirus disease associate with accelerated renal allograft senescence. The association between post-transplant events and replicative senescence has not yet been evaluated in a human setting.

Methods

In a cohort of 134 kidney allograft recipients, we performed protocol-specified renal allograft biopsies at three months, one year, two years and five years after transplantation (N=579 biopsies). We used quantitative real-time PCR to measure intrarenal relative average telomere length (T/S ratio).

Results

At 5 years after transplantation, shorter intrarenal telomere length was associated with male donor gender, and older donor age, donor history of hypertension, and donor cardiovascular risk, which confirms the associations observed in native kidneys. Recipient characteristics and post-transplant events like delayed graft function, acute rejection episodes, presence of donor-specific antibodies, cytomegalovirus disease and immunosuppressive regimen did not associate with alterations of intrarenal telomere length at 5 years. Independent of donor age and donor cardiovascular risk, intrarenal arteriosclerosis in 5y protocol biopsies, and progressive arteriosclerosis over time after transplantation, associated with shorter telomere length.

Moreover, telomere attrition augments the association between older donor age and the presence of severe arteriosclerosis. In the group with the oldest donor age and shortest telomere length, there was significantly more severe arteriosclerosis (43%) in protocol biopsies at five year after transplantation, compared to other combinations. Intrarenal arteriosclerosis at 5 years after transplantation did not associate with post-transplant clinical events.

Interpretation

We demonstrate that intrarenal telomere length at 5 years after transplantation, as marker for replicative senescence, associates with renal arteriosclerosis, and reflects kidney donor characteristics, but not post-transplant events.

CITATION INFORMATION: De Vusser K, Martens D, Lerut E, Kuypers D, Nawrot T, Naesens M. Replicative Senescence and Arteriosclerosis After Kidney Transplantation. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Vusser KDe, Martens D, Lerut E, Kuypers D, Nawrot T, Naesens M. Replicative Senescence and Arteriosclerosis After Kidney Transplantation. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/replicative-senescence-and-arteriosclerosis-after-kidney-transplantation/. Accessed February 26, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Left-Sided Donor Nephrectomy Predisposes Living Kidney Donors to Latent Adrenal Insufficiency with Symptoms of Fatigue and Inferior Quality of Life.
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.