Session Name: Living Donor Liver Transplant and Partial Grafts
Session Type: Rapid Fire Oral Abstract
Date: Saturday, June 5, 2021
Session Time: 4:30pm-5:30pm
Presentation Time: 4:55pm-5:00pm
*Purpose: Hepatic artery thrombosis (HAT) after liver transplantation is associated with a marked increase in morbidity, being the main cause of graft loss and bile duct complication leading patients’ deaths. Retransplantation is often unavailable in most Asian countries due to donor organ shortage. Herein, we evaluated the outcome of patients with HAT after adult living donor liver transplantation (ALDLT) under aggressive surgical correction strategy.
*Methods: From January 2000 to June 2019, 1,355 recipients underwent ALDLT in Seoul National University Hospital. Surgical redo reconstruction for HAT was applied in every case except the evidence of graft necrosis or late detection (since postoperative day 60) of HAT. Median follow-up period was 89 months. Survival outcomes and the rates of biliary complication of patients with HAT were compared with others without HAT.
*Results: Postoperative HAT was developed in 33 cases (2.4%) at a median time of 3.5 days (range 1-82). Overall graft survival rates were lower in patients with HAT (84.8%) than others without HAT (98.0%) (P<0.001). However, patient survival rates were similar between two groups (72.7% vs. 83.8%, P=0.115). Biliary complication rates were higher in patients with HAT (54.5%) than others without HAT (32.0%) (P=0.008). Among 33 patients with HAT, 30 patients (90.9%) underwent redo arterial reconstruction. The technical success rate of redo reconstruction was 83.3% (n=25). After redo-reconstruction, 3 patients (10.0%) underwent retransplantation and 76.6% of patients (n=23) were finally survived. Another 3 patients with HAT underwent conservative management (n=2) and retransplantation directly (n=1).
*Conclusions: HAT after ALDLT was associated with increased rates of biliary complication and significantly attenuates graft survival outcome. However, aggressive surgical treatment can save the graft in 90% without retransplantation and patient survival was not affected.
To cite this abstract in AMA style:Hong S, Yi N, Hong K, Han E, Suh S, Lee J, Hong S, Choi Y, Jin U, Chang H, Lee K, Suh K. Re-Do Hepatic Artery Reconstruction for Thrombosis Can Save Grafts and Patients without Retransplantation: Lessons Learned from 1,355Adult Living Donor Liver Transplantations [abstract]. Am J Transplant. 2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/re-do-hepatic-artery-reconstruction-for-thrombosis-can-save-grafts-and-patients-without-retransplantation-lessons-learned-from-1355adult-living-donor-liver-transplantations/. Accessed August 11, 2022.
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