ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Predicting Immunologic Risk for Acute Rejection in Pediatric Liver Transplantation.

S. Antala, L. Bow, R. Morotti, G. Gan, D. Yanhong, U. Ekong, S. Emre.

Yale University, New Haven, CT

Meeting: 2017 American Transplant Congress

Abstract number: 77

Keywords: HLA antibodies, Liver transplantation, Rejection

Session Information

Session Name: Concurrent Session: Pediatric Liver

Session Type: Concurrent Session

Date: Sunday, April 30, 2017

Session Time: 2:30pm-4:00pm

 Presentation Time: 2:54pm-3:06pm

Location: E271a

Background: Studies in heart, lung, kidney, & liver transplantation (LT) indicate an increased negative impact of antibodies (Ab) to HLA on allograft outcome.

Aim: To describe the frequency & timing of anti-HLA donor specific antibody (DSA) appearance following pediatric LT & the association between the presence of anti-HLA DSA & T-cell mediated rejection (ACR), viral infection, autoAb, & number of HLA antigen (Ag) mismatches.

Methods: Patients followed at our center from 7/31/98-2/29/16 were included (n=63). Anti-HLA DSA was screened in 42 LT recipients. DSA MFI >1000 was considered positive & evaluated retrospectively for ACR.

Results: 22 developed anti-HLA Class II DSA;20 did not Those with Class II DSA had a higher rate of ACR (63.1% vs. 26.6%; p=0.03)

DSA Class II: Yes DSA Class II: No p value
Any enzymes elevated Yes 14 (63.63 %) 16 (80 %) 0.39
No 8 (36.36 %) 4 (20 %)
EBV Yes 5 (27.78 %) 3 (21.43 %) 1.00
No 13 (72.22 %) 11 (78.57 %)
ACR on liver pathology Yes 12 (63.16 %) 4 (26.67 %) 0.034
No 7 (36.84 %) 11 (73.33 %)
Any autoAb present Yes 5 (31.25 %) 3 (25 %) 1.00
No 11 (68.75 %) 9 (75%)

Rejection episodes coincided with DSA detection. Recipients with DQ Ag mismatches were less likely to have anti-smooth muscle Ab (4.76% vs. 75%; p=0.007). DSA appeared relatively early at 6-12 months post transplant DQ Ag mismatch was not significantly associated with Class II DSA or ACR.

Conclusion: Ab-mediated mechanisms targeting HLA Ag may trigger immune responses like ACR. DQ Ag mismatch is not significantly correlated with ACR or de novo autoimmune hepatitis.

CITATION INFORMATION: Antala S, Bow L, Morotti R, Gan G, Yanhong D, Ekong U, Emre S. Predicting Immunologic Risk for Acute Rejection in Pediatric Liver Transplantation. Am J Transplant. 2017;17 (suppl 3).

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Antala S, Bow L, Morotti R, Gan G, Yanhong D, Ekong U, Emre S. Predicting Immunologic Risk for Acute Rejection in Pediatric Liver Transplantation. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/predicting-immunologic-risk-for-acute-rejection-in-pediatric-liver-transplantation/. Accessed June 6, 2025.

« Back to 2017 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences