Date: Tuesday, May 2, 2017
Session Time: 2:30pm-4:00pm
Presentation Time: 2:54pm-3:06pm
The impact of EAD on post-LT renal recovery remains unknown. Aim: To assess the impact of post-LT EAD on renal recovery and post-LT survival. Methods: 1325 1ry LT recipients were grouped according to pre-LT kidney function into: group A=LT Cr≤1.5mg/dl (n=1093), group B=LT Cr>1.5mg/dl but not on renal replacement therapy (RRT) (n=156) and group C=on RRT (n=76). EAD was defined as at least one of the following:1) POD7 INR ≥1.6, 2) POD 7 bilirubin ≥10mg/dl or 3) ALT or AST ≥2000 IU/ml within 1 week. Renal recovery was defined as freedom from RRT and a Cr <2mg/dl 1 month after LT. Results:Patients' demographics are presented in table 1.
|Group A n=1093||Group B n=156||Group C n=76||P|
|1 month Cr||1.1±0.4||1.5±0.6||1.5±0.8||0.001|
EAD developed in 358 (27%) patients. Overall, pre-LT kidney function negatively affected post-LT survival Figure 1. When patients were stratified by EAD, pre-LT kidney function impacted post-LT survival only in the EAD group Figure 2A, 2B. 85% EAD vs 92% no-EAD achieved renal recovery at 1 month (P=0.001). Conclusions: 1) Pre-LT kidney function negatively impacts post-LT survival only in patients with post-LT EAD. 2) Post-LT renal recovery is less likely following EAD development. 3) Preventing EAD might be beneficial in improving LT outcome in patients with pre-LT renal dysfunction.
CITATION INFORMATION: Wadei H, Mai M, Taner B, Croome K, Keaveny A, Mai L, Lee D. Post-Liver Transplant (LT) Early Allograft Dysfunction (EAD) Modulates the Effect of Pre-LT Kidney Function on Post-LT Survival. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:Wadei H, Mai M, Taner B, Croome K, Keaveny A, Mai L, Lee D. Post-Liver Transplant (LT) Early Allograft Dysfunction (EAD) Modulates the Effect of Pre-LT Kidney Function on Post-LT Survival. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/post-liver-transplant-lt-early-allograft-dysfunction-ead-modulates-the-effect-of-pre-lt-kidney-function-on-post-lt-survival/. Accessed June 6, 2020.
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