2019 American Transplant Congress » Poster Session D: Lymphocyte Biology: Signaling, Co-Stimulation, Regulation

6:00pm-7:00pm

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Lymphocyte Biology and Transplant Immunity

L. Qiu¹, J. Wang², R. Fernandez³, X. Yeap¹, S. Han¹, F. Zheng¹, C. Lin², Z. J. Zhang¹

6:00pm-7:00pm

A Regulatory T Cell-Intrinsic Role for Ikaros in Acquired Transplant Tolerance

R. M. Thomas, L. Wang, W. W. Hancock, A. D. Wells

6:00pm-7:00pm

Anti-CD272 Antibody (6B2) Induced Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allograft

E. Yin, M. Uchiyama, Y. Yamamoto, M. Niimi

6:00pm-7:00pm

CD4 T Cell is Essential in an Innate-Immune Driven Ischemia-Reperfusion Injury in Mouse and Human

S. Kageyama¹, K. Kadono¹, H. Hirao¹, K. Nakamura¹, T. Ito², K. J. Dery¹, D. Oncel¹, R. A. Sosa³, E. F. Reed³, F. M. Kaldas², R. W. Busuttil², J. W. Kupiec-Weglinski¹, Y. Zhai¹

6:00pm-7:00pm

Cd45rb Mediates Cd8⁺T Cell Persistence In An Allogeneic Heterologous Immune Response

S. M. Krummey, A. B. Morris, M. L. Ford

6:00pm-7:00pm

EBV⁺ PTLD Cell Lines Secrete Exosomes Containing microRNAs That Alter Immune Responses

S. Syed, E. Maloney, A. Hui, O. Martinez, S. Krams

6:00pm-7:00pm

Early T Cell Infiltration is Modulated by PD-1/PD-L1 Interactions in Kidney Graft

Y. Shim, R. Fan, N. Dvorina, W. Baldwin

6:00pm-7:00pm

Evaluating Allo-Specific CD57⁺ T Cells during Memory and Proliferative Responses

A. Lucander, H. Xu, A. Kirk

6:00pm-7:00pm

Examination of a Novel Immunoregulatory Marker in Kidney and Lung Transplant Recipients

A. D. Desai¹, G. J. Kavalam², A. Chandraker², S. Tripathi²

6:00pm-7:00pm

Gene Expression Profiles in CD8+ T Cells in Chronic Antibody-Mediated Rejection (CAMR) of Kidney Transplantation

P. Pontrelli¹, F. Rascio², M. Accetturo¹, G. Castellano¹, S. Simone¹, G. Stallone², L. Gesualdo¹, G. Grandaliano²

6:00pm-7:00pm

High-Throughput Immune Synapse Detection as a Tool for the Measurement of T Cell Alloreactivity

S. Moshkelgosha, S. C. Juvet

6:00pm-7:00pm

IFNAR Signaling Augments Plasmacytoid Dendritic Cell Activation during Costimulation Independent Rejection

J. Habib, D. Mathews, Y. Dong, A. Stephenson, A. Ghosh, C. Breeden, A. Adams

6:00pm-7:00pm

IL-10+ Plasma Cells Are Not Required for Breg Activity and Are Counterbalanced by Novel Pro-Inflammatory Plasma Cells

Q. Ding, Y. Zhou, Z. Song, L. Zeng, D. Rothstein

6:00pm-7:00pm

In Vivo Treg Expansion under Costimulation Blockade Targets Early Rejection and Improves Long-Term Outcome

C. Schwarz¹, B. Mahr², L. Unger¹, N. Pilat², H. Regele³, T. Wekerle²

6:00pm-7:00pm

Inhibition of Th1 and Th17 Cell Differentiation and Prolonged Graft Survival through NFAT Pathway Downregulation

C. Dai¹, R. Tan¹, B. Yang¹, J. Markmann², D. Chen¹, L. Wei¹, Z. Chen¹

6:00pm-7:00pm

Laminin Dependent T Cell Migration Determines Allograft Survival

L. Li, M. Shirkey, W. Piao, Y. Xiong, V. Saxena, T. Zhang, B. M. Cerel, C. Paluskievicz, J. S. Bromberg

6:00pm-7:00pm

Novel In Vitro Germinal Center Culture System Demonstrates More Aggressive B Cell to Plasma Blast Differentiation in Allosensitized Nonhuman Primates

P. Schroder, J. Yoon, R. Schmitz, Z. Fitch, J. Kwun, S. J. Knechtle

6:00pm-7:00pm

Novel Role of Qa-1-Restricted Immunoregulation in Murine Cardiac Transplantation

J. Y. Choi¹, S. K. Eskandari¹, J. Assaker¹, I. Sulkaj¹, S. Cai¹, H. Allos¹, M. Uehara¹, M. Mohammad¹, B. S. Al Dulaijan¹, A. Bano¹, E. Al Huassain¹, H. I. Cantor², J. R. Azzi¹

6:00pm-7:00pm

Peripheral Blood Regulatory T Cells In The Folow In The Kidney-transplant Patients

M. A. Carmona-Escamilla¹, G. Queipo², L. A. Garcia-Mosqueda³, R. Lascurain⁴

6:00pm-7:00pm

Phenotypic and Functional Analysis of Non-Activated and Allo-Activated Eomesodermin+ CD8+ T Cells in Humans and Nonhuman Primates

A. Perez Gutierrez¹, A. W. Thomson², D. M. Metes², M. B. Ezzelarab²

6:00pm-7:00pm

Prolonged Cold Ischemic Storage Induces Allograft Necro-Inflammation That Increases Graft Susceptibility to T Cell Mediated Rejection

N. Chun¹, R. Ang¹, J. Horwitz¹, R. Fairchild², W. Baldwin III², A. Ting¹, P. S. Heeger¹

6:00pm-7:00pm

Rcor1 and Regulation of Foxp3+ T-Regulatory Cells In Vitro and In Vivo

Y. Xiong, L. Wang, R. Han, W. W. Hancock

6:00pm-7:00pm

S1PR1 and S1PR4 Regulate T Cell Migration into Afferent Lymphatics

Y. Xiong¹, W. Piao¹, C. Brinkman¹, L. Li¹, J. Kulinski², A. Olivera², A. Cartier³, T. Hla⁴, K. Hippen⁵, B. Blazar⁶, S. Schwab⁷, J. Bromberg¹

6:00pm-7:00pm

Sphingosine 1-Phosphate Receptors and CCR7 Sequentially Coordinate T Cell Migration

Y. Xiong¹, W. Piao¹, C. Brinkman¹, J. Kulinski², A. Olivera², A. Cartier³, T. Hla⁴, K. Hippen⁵, B. Blazar⁵, S. Schwab⁶, J. Bromberg¹

6:00pm-7:00pm

The Adapter Protein TSAd Regulates Mitochondrial Lck Activity and is Potent to Enhance Immunoregulation Following Transplantation

J. Wedel¹, M. P. Stack¹, T. Seto¹, K. Liu¹, I. E. Stillman², D. M. Briscoe¹

6:00pm-7:00pm

The Immunomodulatory Role of Type I Interferons in Alloimmunity

I. Sulkaj, H. Allos, S. K. Eskandari, J. M. Safadi, J. Y. Choi, B. S. Al Dulaijan, E. Al-Hussain, S. Cai, J. R. Azzi

6:00pm-7:00pm

Thymoglobulin Induction with Tacrolimus and Everolimus Maintenance Therapy in Elderly Kidney Transplantation Results in Prolonged Lymphocyte Depletion and Do Not Favor Regulatory Profile

E. David-Neto¹, G. Ramos de Freitas¹, M. Fernandes¹, F. Agena¹, F. Brambate Carvalhinho Lemos¹, F. Jota de Paula¹, V. Coelho², N. Zocoler Galante¹

6:00pm-7:00pm

Treg Lymphotoxin and Lymphatic Endothelial Cell Lymphotoxin Receptor Interactions Are Required for Treg Stability and Allograft Protection

V. Saxena, W. Piao, L. Li, C. M. Palusckievicz, Y. Xiong, T. Simon, J. S. Bromberg