ATC Abstracts

American Transplant Congress abstracts

Peripheral Blood Regulatory T Cells In The Folow In The Kidney-transplant Patients

1Nephrology, Pemex, CDMX, Mexico, 2Genetics, Hospital General, CDMX, Mexico, 3UNAM, CDMX, Mexico, 4Inmunologia, UNAM, CDMX, Mexico

Meeting: 2019 American Transplant Congress

Abstract number: D146

Keywords: , ,

Session Information

Session Name: Poster Session D: Lymphocyte Biology: Signaling, Co-Stimulation, Regulation

Session Type: Poster Session

Date: Tuesday, June 4, 2019

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall C & D

*Purpose: Investigate the peripheral blood levels of CD4+CD25+FOXP3p3+ regulatory T cells (Tregs) in patients with kidney transplant at least one year after kidney transplantation and compare it with chronic disease undergo hemodialysis and healthy controls.

*Methods: Twelve renal-transplant patients, 12 patients with chronic kidney disease (CKD) stage G5 on dialysis, and 13 healthy control individuals were evaluated regarding the proportion of Tregs in their peripheral blood via flow cytometry.

*Results: The renal-transplant patients had a significantly lower proportion of Tregs than the hemodialysis-CKD patients and healthy controls (P<0.01). In contrast, the hemodialysis-CKD patients showed higher levels of Tregs than the renal-transplant patients and the healthy controls (P<0.01)

*Conclusions: The high level of peripheral blood Tregs in the hemodialysis-CKD patients suggests a chronic inflammatory state. However, the low frequency of Tregs in the peripheral blood from the renal-transplant patients suggests an unfavorable prognosis for allograft immune tolerance.

To cite this abstract in AMA style:

Carmona-Escamilla MA, Queipo G, Garcia-Mosqueda LA, Lascurain R. Peripheral Blood Regulatory T Cells In The Folow In The Kidney-transplant Patients [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/peripheral-blood-regulatory-t-cells-in-the-folow-in-the-kidney-transplant-patients/. Accessed May 10, 2025.

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