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Pathological Characteristics of BK Polyomavirus Nephropathy with Glomerular Involvement

G. Huang1, X. Chen1, W. Chen2, S. Yang2, J. Qiu1

1Department of Organ Transplantation, 1st Affiliated Hospital, Zhongshan University, Guangzhou, China, 2Department of Pathology, 1st Affiliated Hospital, Zhongshan University, Guangzhou, China

Meeting: 2020 American Transplant Congress

Abstract number: A-214

Keywords: Biopsy, Glomerulonephritis, Kidney/liver transplantation, Polyma virus

Session Information

Session Name: Poster Session A: Kidney: Polyoma

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: This study aimed to investigate the pathological characteristics of BK polyomavirus-associated nephropathy with glomerular involvement in kidney transplant recipients.

*Methods: Forty-four patients with glomerular BK polyomavirus (BKPyV) infection were included for analysis. Immunohistochemical (IHC) staining was performed on paraffin sections using monoclonal mouse anti-SV40 large T antigen antibody.

*Results: In BKPyV-infected glomeruli, the glomerular parietal epithelial cells (GPECs) were swollen, hyperchromatic, and enlarged, with an increased nuclear to cytoplasm (N/C) ratio and smudgy basophilic intra-nuclear viral inclusions. IHC staining revealed the distribution of BKPyV involvement in GPECs, podocytes, and shedding cells within Bowman’s space (Figure 1). Banff g1 glomerulitis was found in 43.2% of the biopsies. Mononuclear inflammatory cells were found mainly in the glomerular capillary wall, and occasionally among the proliferating GEPCs. Peri-glomerular fibrosis was the most common chronic change (65.9%). Notably, BKPyV affected GEPC proliferation and caused crescent formation (7 biopsies, 15.9%). Three biopsies exhibited fibrous crescents and the absence of viral inclusions. The other 4 biopsies exhibited cellular and fibro-cellular crescents, with viral cytopathic changes and positive IHC staining in the proliferative GPECs (Figure 2). Electron microscopy showed viral particles in both GPECs and podocytes. Most BKPyV-infected GPECs were degenerative, with mitochondrial swelling, endoplasmic reticulum expansion, and multi-layered membranous structure formation. Twelve (27.3%) patients received repeat biopsies within 1.6 to 39.5 months (median: 13.5 months), but none revealed persistent glomerular BKPyV infection.

*Conclusions: BKPyVAN with glomerular involvement presents distinct glomerular changes.

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To cite this abstract in AMA style:

Huang G, Chen X, Chen W, Yang S, Qiu J. Pathological Characteristics of BK Polyomavirus Nephropathy with Glomerular Involvement [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/pathological-characteristics-of-bk-polyomavirus-nephropathy-with-glomerular-involvement/. Accessed May 11, 2025.

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