2016 American Transplant Congress
MiRNA-200b Inhibits Epithelial-Mesenchymal Transition in TGF-β1 Induced Human Bronchial Epithelial Cells.
Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.
The role of TGF-β1 in mediating extracellular matrix remodeling during the pathogenesis of lung fibrosis has been well defined. Dysregulated expression of miRNA is increasingly…2016 American Transplant Congress
Hydrogen Sulphide Is an Important Regulator of Erythropoietin Synthesis in Patients with Anemia of Chronic Kidney Disease.
Anemia affects 90% of hemodialysis patients and is a tremendous concern for patients and health care providers. CKD leads to chronic interstitial fibrosis which leads…2016 American Transplant Congress
Everolimus Abrogates C5a and TGFβ Mediated Perycite-to-Myofibroblast Transition (PMT) Inhibiting Vascular Rarefaction.
Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.
Microvascular pericytes have detrimental effects on tubulo-interstitial fibrosis via PMT. However, therapeutic strategies that might interfere with this process are currently lacking. We aimed to…2016 American Transplant Congress
The Apoptosis of the Tracheal Epithelia Increase the Recipient's MSCs Derived Myofibroblasts in Allografts to Exacerbate Obliterative Bronchiolitis After Tracheal Transplantation in Mice.
Background: The long-term outcome of lung transplantation is impeded by obliterative bronchiolitis (OB). However, the current treatment cannot effectively prevent the process of OB. The…2016 American Transplant Congress
Novel Nuclear Factor-κB Activation Inhibitor, Dehydroxymethylepoxyquinomicin, Prevents the Development of Chronic Cyclosporine Nephropathy in Rats.
Purpose:The nephrotoxicity of the calcineurin inhibitors including cyclosporine is a major problem in the kidney transplantation. We investigated the effect of a novel nuclear factor-κB…2016 American Transplant Congress
Transplantation of Islet Preconditioned with Hydrogen Sulfide Enhances the Graft Function in Diabetic Mice.
Background: Islet transplantation is a promising therapy for Type 1 diabetes. However, successful outcomes are hampered by the poor survival of the donor cells after…2016 American Transplant Congress
In Vivo and In Vitro Characterization of 1.5 mm Ba2+-Alginate Macro-Encapsulated Cynomolgus Monkey Islets.
Introduction:Micro-encapsulation of islets for the treatment of Type I diabetes has shown limited efficacy in small-scale clinical trials. The lack of success may be related…2016 American Transplant Congress
Establishment of SCID Pigs Cell Lines to Prevent Immunodeficiency Using RGEN System.
Severe immune disorder is the biggest problem in xenotransplantation. To overcome the the problem, producing severe combined immune deficiency (SCID) pigs which lack T cell…2016 American Transplant Congress
Intragraft Molecular Pathways Associated with Tolerance Induction in Renal Transplantation.
Organ transplantation relies upon nonspecific immunosuppressive (IS) agents to prevent graft rejection. However, IS drugs have significant toxicities and chronic rejection occurs despite their usage.…2016 American Transplant Congress
Ex Vivo Expansion and Functional Characterization of Human Alloantigen-Specific Regulatory T Cells.
Purpose: Regulatory T cells (Tregs) have been associated with clinical transplant tolerance and they have been shown to prolong graft survival in animal models without…
American Transplant Congress abstracts