2016 American Transplant Congress
Human B Cell Cytokines Predict Renal Allograft Rejection and Early Transplant Outcomes.
In renal transplantation, non-invasive biomarkers that are predictive and allow for early intervention are limited. Here we report findings from a prospective longitudinal study of…2016 American Transplant Congress
Elevated Intragraft Expression of Innate Immunity and Cell Death-Related Markers Characterizes Deceased Donor Conditions and Is a Risk Factor for Adverse Graft Outcome.
Background: The innate immune response is increasingly being recognized in allograft injury after kidney transplantation. We aimed to establish the relationship of innate immune gene…2016 American Transplant Congress
IFTA Is Linked to Urinary Microbiome Changes.
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.
Purpose: The microbiome is important to human health and alteration may lead to aberrant immunity and disease. Interstitial fibrosis and tubular atrophy(IFTA) occurs in 20%…2016 American Transplant Congress
YKL-40 Predicts Renal Recovery in Deceased-Donor Transplantation.
Background Deceased-donor kidneys with acute kidney injury (AKI) are often discarded for fear of poor transplantation outcomes. Donor biomarkers that predict post-transplant renal recovery could…2016 American Transplant Congress
Deceased Donor Urine C5a Predicts Donor and Recipient Acute Kidney Injury.
Anti-complement therapies are currently being tested in human kidney transplantation to prevent DGF. In this large prospective, cohort study of 469 deceased organ donors, we…2016 American Transplant Congress
Financial Cost of Cold Ischemia Time in Kidney Transplantation.
PURPOSE: A new kidney allocation system (KAS) was implemented in December 2014 using the kidney donor profile index (KDPI), which prioritizes historically-disadvantaged populations. While KAS…2016 American Transplant Congress
Many Discarded Kidneys Are Similar to Kidneys Accepted for Transplantation as Judged by Their Histologic Lesions and Molecular AKI Scores.
There is an increase in the number kidneys from older brain dead donors (DBD). Many are discarded based on conventional features (clinical or histology). Thus…2016 American Transplant Congress
Delayed Graft Function (DGF) Does Not Accelerate Progression of Fibrosis During the First Year After Deceased Donor Kidney Transplantation.
BackgroundOur aim was to study the impact of DGF on the progression of interstitial fibrosis during the first post-transplant year.MethodsWe included all patients who received…2016 American Transplant Congress
Influence of AKIN Stage on the Outcome of Deceased Donor Kidney Transplantation (DDKTx).
BackgroundTransplanting kidneys from donors with AKI is one of the methods to minimize the disparity between numbers of listed patient and donor pool. Our aim…2016 American Transplant Congress
Is Prolonged Cold Ischemia a Contraindication to Using Kidneys from Acute Kidney Injury Donors?
Elevated deceased donor (DD) serum creatinine (SCr) levels and prolonged cold ischemia time (CIT) are major independent reasons for kidney discard following organ recovery. Many…
American Transplant Congress abstracts