Date: Saturday, June 11, 2016
Session Name: Poster Session A: Living Donor Liver Transplantation
Session Time: 5:30pm-7:30pm
Presentation Time: 5:30pm-7:30pm
Location: Halls C&D
Lower limit of graft size in adult Living donor liver transplantation (LDLT) is not well established. This study examines the outcomes with use of small-for-size grafts (SFSGs) in LDLT in a single center. Graft-to-recipient weight ratio (GRWR) of less than 0.8 was designated as SFSG. From 2002-15, 41 cases of adult-to-adult LDLT with a GRWR of <0.8 were performed at the center. These constituted 24 left lobes. These were compared to all adult LDLTs with GRWR >/=0.8 (n=95) carried out in the same time period. Median follow-up duration was 3.1 years. Mean GRWR of SFSGs was 0.66 versus 1.06 (p<0.0001) in the larger graft group. SFSGs consisted of significantly more left lobes (58.5% versus 21%, p<0.0001) as compared to the larger group. HCV and HCC constituted a significantly higher proportion of cases in the smaller group (60.9% versus 42.1%, p=0.043, 34% versus 16.8%, p=0.026). Preoperative MELD scores were not different between the groups
|Characteristic||GRWR <0.8 (mean) n=41||GRWR >/=0.8 (mean) n=95||p value|
|Mean graft weight (gms)||525||781.38||<0.0001|
|Small for size syndrome||7.3%||3.16%||0.278|
. Rate of biliary strictures was not different between the groups (39% versus 31.6%, p=0.4). Liver synthetic function and kidney function at 1 and 3-years post transplant were comparable between the groups. The 1 and 3-year graft survival for GRWR<0.8 group were 87% and 80% compared to 90% and 86% for the larger group (p=0.55) . The 1 and 3-year patient survival for GRWR<0.8 group were 89% and 82% compared to 92% and 88% for the larger group (p=0.55) . Use of smaller grafts composed predominantly of left lobes had comparable outcomes with larger grafts and potentially expands applicability of LDLT.
CITATION INFORMATION: Klair T, Przybyszewski E, Samstein B. Outcomes of Small-for-Size Grafts in Adult Living Donor Liver Transplantation. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Klair T, Przybyszewski E, Samstein B. Outcomes of Small-for-Size Grafts in Adult Living Donor Liver Transplantation. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/outcomes-of-small-for-size-grafts-in-adult-living-donor-liver-transplantation/. Accessed June 4, 2020.
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