ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Outcome of Renal Transplantation in Systemic Amyloidosis

S. Law1, L. Helen2, T. Resk2, A. Wechalekar2, J. Gillmore2, R. Motallebzadeh1

1Renal Medicine, Royal Free Hospital, London, United Kingdom, 2UCL Division of Medicine, National Amyloidosis Centre, London, United Kingdom

Meeting: 2019 American Transplant Congress

Abstract number: C57

Keywords: Graft failure, Graft function, Graft survival, Recurrence

Session Information

Session Name: Poster Session C: Kidney Complications: Late Graft Failure

Session Type: Poster Session

Date: Monday, June 3, 2019

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall C & D

*Purpose: Systemic amyloidosis accounts for approximately 0.8% of end stage renal disease (ESRD) in the UK. Outcomes following renal transplantation in systemic amyloidosis were historically poor, but there is a paucity of data on renal transplant outcomes following recent therapeutic advances which have benefited patients with systemic amyloidosis generally. We sought to determine renal allograft and patient survival in UK patients with ESRD from systemic amyloidosis.

*Methods: Outcomes following renal transplantation among 94 patients with systemic AA and AL amyloidosis being followed at the UK National Amyloidosis Centre (NAC) who underwent renal transplantation between 1989 and 2018 were compared with those of age-matched renal transplant recipients with diabetic and non-diabetic nephropathy recipients held in the NHSBT database.

*Results: See Graphs 1 and 2

Death-censored graft survival was 96%, 96%, 96% and 81% in AA, and 98%, 98%, 93% and 93% in AL amyloidosis at 1,3, 5 and 10 years respectively. Overall patient survival was 92%, 92%, 81% and 68% in AA and 95%, 93%, 76%, 34% in AL amyloidosis at 1, 3, 5, and 10 years respectively. Twenty-five amyloidosis patients died with a functioning renal allograft and 9 suffered allograft loss, 3 within a month due to operative complications or rejection, 3 from recurrent amyloid (all AA) and 3 multifactorial but with recurrent amyloid (1AL, 2AA).

*Conclusions: Patient and renal allograft survival following renal transplantation in AA amyloidosis is similar to that in diabetic nephropathy. Despite excellent death-censored renal allograft survival in AL amyloidosis, reflecting prevention of recurrence of amyloid in renal allografts due to successful suppression of the underlying clonal dyscrasia with chemotherapy, patient survival following renal transplantation in this cohort was inferior to age-matched diabetic controls. This data indicates that carefully selected patients with systemic amyloidosis can achieve good outcomes following renal transplantation.

 border=

 border=

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Law S, Helen L, Resk T, Wechalekar A, Gillmore J, Motallebzadeh R. Outcome of Renal Transplantation in Systemic Amyloidosis [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/outcome-of-renal-transplantation-in-systemic-amyloidosis/. Accessed June 1, 2025.

« Back to 2019 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences