Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall C & D
*Purpose: The purpose of this study was to examine the 90-day complications that occurred after intestinal transplantation and to determine whether they effect 5-year patient or graft survival.
*Methods: Retrospective review of intestinal transplant recipients between 11/2003 and 11/2017 at a single-center academic institution. Complications were classified using the Clavien-Dindo system. Five-year graft and patient survival were compared between those with varying degrees of complications.
*Results: Of the 214 patients who underwent intestinal transplant, 201 (94%) experienced a Grade II or higher complication, 148 (69%) experienced a Grade III or higher complication, 69 (32%) experienced a Grade IV or higher and 13 (6%) patients died (Grade V) within 90 days of transplant. The average number of complications was 2.6. Medical complications occurred in 156 (75%) patients while 132 (64%) patients had a surgical complication of some kind. Medical complications were categorized as infectious (59%), renal (29%), cardiopulmonary (29%), immunologic (26%), gastrointestinal (12%), hematologic (12%) and neurologic (3%). Surgical complications were categorized as enteric (15%), abscess (15%), chylous (14%), bleeding (14%), wound (13%), thrombosis (7%) and biliary (3%). Patients with Clavien-Dindo Grade IV complications had significantly worse five-year graft and overall survival compared to those with less severe complications (57% vs 72%, p = 0.012 and 58% vs 75%, p = 0.007, respectively)
*Conclusions: Complications are common after intestinal transplantation and are predominantly infectious. Patients suffering from severe complications (Clavien-Dindo IV) within the first 90 days after transplantation have worse graft and overall survival at 5 years.
To cite this abstract in AMA style:Zimmerman A, Hawksworth J, Kroemer A, Radkani P, Khan K, Kaufman S, Yazigi N, Subramanian S, Fishbein T, Matsumoto C. Ninety-Day Complications in 214 Intestinal Transplant Patients: A Calvien-Dindo Analysis and Assessment of Long Term Outcomes [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/ninety-day-complications-in-214-intestinal-transplant-patients-a-calvien-dindo-analysis-and-assessment-of-long-term-outcomes/. Accessed May 5, 2021.
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