Long-Term Preservation of Renal Function in Liver Transplant Recipients with Rabbit Anti-Thymocyte Globulin Induction and Delayed Initiation of Calcineurin Inhibitors.
Transplant Institute, Henry Ford Health System, Detroit, MI
Meeting: 2017 American Transplant Congress
Abstract number: D196
Keywords: Calcineurin, Liver transplantation, Renal function
Session Information
Session Name: Poster Session D: Liver - Kidney Issues in Liver Transplantation
Session Type: Poster Session
Date: Tuesday, May 2, 2017
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall D1
Methods: A single-center retrospective analysis of medical records of 989 liver transplant recipients from 2001-2010 were reviewed and evaluated for patients who received thymo induction with delayed initiation of CNI. All patients received mycophenolate mofetil (500mg BID) and steroids (x3 months post-livert ransplant).
Results: Of 989 liver transplant recipients reviewed, 312 received thymo induction with delayed initiation of CNI. Median follow-up period was 839±629.12 (±SD) days post-liver transplant. Results are reported in Tables 1 and 2.
| Table 1 | Baseline (BL) | 1 Year (1yr) | Last Day of Follow-Up (FU) | 1yr vs. BL | FU vs. BL |
| SCr (mg/dL) | 2±1.27 | 1.3±0.94 | 1.40±1.14 | p<0.01 | p<0.01 |
| eGFR (mL/min/1.73 m2) | 34±22.81 | 56±23.24 | 55±38.28 | p<0.01 | p<0.01 |
| Table 2 | ||
| Variable | Statistic | |
| Hospital Length of Stay (days) | 14±15.52 | |
| Age | 54±9.6 | |
| Race | Caucasian | 68.91% |
| African American | 20.83% | |
| Other | 9.93% | |
| Gender | Male | 66.67% |
| MELD | 22±7.10 | |
| Thymo | # of Doses | 3±1.27 |
| # Days on Thymo | 5±8.54 | |
| Dose (mg/kg) | 1.84±1.27 | |
| CNI Start Time (days) | 5±2.47 | |
| Outcomes at FU | Deaths | 12.50% |
| Re-transplant | 4.81% | |
| Dialysis | 7.05% | |
| Cancer | 1.28% | |
| # Days on FU | 839±629.12 | |
| Immunosuppressive therapy at FU | FK | 60.26% |
| CsA | 21.79% | |
| Rapa | 12.82% | |
| Other | 4.49% | |
| Median±SD | ||
In conclusion, in our analysis, we found that thymo induction with delayed initiation of CNI therapy in liver transplant patients is safe and associated with long-term improvements in renal function.
CITATION INFORMATION: Bajjoka I, Yaldo A, Crombez C, Brown K, Abouljoud M. Long-Term Preservation of Renal Function in Liver Transplant Recipients with Rabbit Anti-Thymocyte Globulin Induction and Delayed Initiation of Calcineurin Inhibitors. Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Bajjoka I, Yaldo A, Crombez C, Brown K, Abouljoud M. Long-Term Preservation of Renal Function in Liver Transplant Recipients with Rabbit Anti-Thymocyte Globulin Induction and Delayed Initiation of Calcineurin Inhibitors. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/long-term-preservation-of-renal-function-in-liver-transplant-recipients-with-rabbit-anti-thymocyte-globulin-induction-and-delayed-initiation-of-calcineurin-inhibitors/. Accessed November 21, 2024.« Back to 2017 American Transplant Congress