Long-Term Liver Function of Deceased Liver Transplantation Using Hepatitis B Surface Antigen Positive Grafts.
1Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, Taoyuan, Taiwan
2Hepatology, Chang-Gung Memorial Hospital, Taoyuan, Taiwan.
Meeting: 2016 American Transplant Congress
Abstract number: B277
Keywords: Graft function, Hepatitis B, Liver transplantation
Session Information
Date: Sunday, June 12, 2016
Session Name: Poster Session B: Liver: MELD, Allocation and Donor Issues (DCD/ECD)
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Background: Deceased donors with hepatitis B [HBs Ag(+)] were not recommended to recover the livers for liver transplantation. However, in endemic area of hepatitis B with lack of liver donation, HBs Ag(+) deceased livers might be transplanted to HBs Ag(+) recipients who were suffered from acute liver failure or hepatocellular carcinoma and living donors were not available. The aim of this study was to examine the liver function status of HBs Ag(+) liver grafts after transplantation.
Materials and methods: The liver transplant recipients with HBs Ag(+) deceased liver grafts and survived from transplantation were included in this study. All the patients were informed that the liver grafts were HBs Ag(+) and the consents were obtained. During the transplant operation, anti-hepatitis B immunoglobulin was not administered. After operation, combination of anti-hepatitis B nucleotide and nucleoside were given to control hepatitis B virus. During post-transplant follow up, liver function and quantitative HBs Ag were measured periodically.
Results: From 2012 to 2015, 11 hepatitis B patients with acute liver failure or hepatocellular carcinoma were transplanted with HBs Ag(+) deceased liver grafts. The median (interquartile) age was 48 with a range from 32 to 61years. The MELD score ranged from 11 to 40. Among the 11 patients, 3 patients died of severe sepsis with multidrug resistant bacteria. The other 8 patients were followed up for 24.3±19.4 months. Six patients had Lamivudine with adefovir, and 2 had entecavir with tenofovir for hepatitis B control. Currently, AST was 25.4±8.5U/L and ALT was 23.1±12.1U/L. HBV DNA was not detectable for all the patients. The median (interquartile) quantitative HBs Ag was 20.8 (0.863 to 58.1) IU/ml with a range from 0.15 to 119.9 IU/ml.
Conclusion: HBV could be well-controlled by combination of anti-hepatitis B nucleotide and nucleoside after transplantation in this study. Quantitate HBs Ag was at very low level and liver function was nearly normal. Transplantation with HBs Ag(+) deceased liver to HBs Ag(+) recipients is feasible to save the patients with good liver function.
CITATION INFORMATION: Lee W.-C, Wang Y.-C, Cheng C.-H, Wu T.-H, Lee C.-F, Soong R.-S, Wu T.-J, Chou H.-S, Chan K.-M, Lee C.-S. Long-Term Liver Function of Deceased Liver Transplantation Using Hepatitis B Surface Antigen Positive Grafts. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:
Lee W-C, Wang Y-C, Cheng C-H, Wu T-H, Lee C-F, Soong R-S, Wu T-J, Chou H-S, Chan K-M, Lee C-S. Long-Term Liver Function of Deceased Liver Transplantation Using Hepatitis B Surface Antigen Positive Grafts. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/long-term-liver-function-of-deceased-liver-transplantation-using-hepatitis-b-surface-antigen-positive-grafts/. Accessed August 13, 2020.« Back to 2016 American Transplant Congress