Incidence and Risks Factors of Kidney Allograft Loss Due to BK Virus: UNOS Data Set
1Transplant Nephrology, Beth Israel Deaconess Medical Center, Boston, MA, 2Transplant Nephrology, University of Missouri-Kansas City School of Medicine/Saint Luke's Health System, Kansas City, MO
Meeting: 2020 American Transplant Congress
Abstract number: D-164
Keywords: Graft failure, Graft survival, Polyma virus, Risk factors
Session Information
Session Name: Poster Session D: Kidney: Polyoma
Session Type: Poster Session
Date: Saturday, May 30, 2020
Session Time: 3:15pm-4:00pm
Presentation Time: 3:30pm-4:00pm
Location: Virtual
*Purpose: BK virus infection can lead to graft dysfunction and loss in kidney transplant patients. Incidence and prevalence of BK Viremia (BKV) and BK Virus Nephropathy (BKVN) have been evaluated previously in single center retrospective studies. Here, we evaluate the incidence and risk factors of kidney allograft loss due to BKVN in the United Network for Organ Sharing (UNOS) data set.
*Methods: We conducted a retrospective cohort analysis of the UNOS database. We identified all patients who received a kidney, simultaneous kidney pancreas (SPK), pancreas after kidney (PAK) and kidney with other organ transplant between January 2000 & December 2018 and compared risk factors of graft loss due to BKVN with functioning kidney graft. Baseline donor and recipient characteristics were compared between groups using Student t-test or Kruskal Wallis test for continuous variables and Chi-2 test for categorical variables. Kaplan meier curve was used to measure graft survival time.
*Results: A total of 1392 (0.42%) patients suffered graft loss due to BKVN. Male gender, African-American race, HLA mismatch ≥3, dialysis vintage, non-preemptive transplant, donor age, type of donor, cold ischemia time, delayed graft function and CMV high risk were significantly associated with BKVN graft loss. The incidence of BKVN graft loss following SPK and PAK transplant was 0.53% and 0.41% respectively. Incidence of BKVN graft loss trended to be higher among the patients who received simultaneous heart and kidney transplant (0.72%).
*Conclusions: Between the year 2000 and 2018 the incidence of graft loss due to BKVN was 0.42% in the UNOS data set. Male gender, African-American race, HLA mismatch ≥3, dialysis vintage, non-preemptive transplant, donor age, type of donor, cold ischemia time, delayed graft function and CMV high risk were significantly associated with BKVN graft loss. 70.1% of patients lost their graft due to BKVN and developed renal failure within 4 years of transplant, which confirms that BKVN is more prevalent during the first few years after transplant and is associated with early graft failure.
To cite this abstract in AMA style:
Patel H, Agrawal K, Pawar A, Leeaphorn N, Cardarelli F, Agrawal N. Incidence and Risks Factors of Kidney Allograft Loss Due to BK Virus: UNOS Data Set [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/incidence-and-risks-factors-of-kidney-allograft-loss-due-to-bk-virus-unos-data-set/. Accessed May 11, 2025.« Back to 2020 American Transplant Congress