ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

In House Oxygen Persufflation of Cold Stored Livers Versus Simple Cold Storage in Extended Criteria Liver Grafts: Results of a Randomized Controlled Clinical Trial

A. Gallinat,1 A. Paul,1 D. Hoyer,1 C. Klein,1 S. Swoboda,1 C. Ose,2 Z. Mathe,1 J. Treckmann,1 T. Minor.3

1Dept. of General-, Viszeral- und Transplantation Surgery, University Hospital Essen, Essen, Germany
2Institute of Computer Science in Medicine, Biostatistics and Epidemiology, University Hospital Essen, Essen, Germany
3Surgical Research Div., Universiy Clinic Surgery, Bonn, Germany.

Meeting: 2015 American Transplant Congress

Abstract number: C114

Keywords: Donors, Graft function, Liver transplantation, marginal, Preservation

Session Information

Session Name: Poster Session C: Liver Donation and Allocation

Session Type: Poster Session

Date: Monday, May 4, 2015

Session Time: 5:30pm-6:30pm

 Presentation Time: 5:30pm-6:30pm

Location: Exhibit Hall E

Two hours of end-ischemic oxygen persufflation of cold stored porcine livers regenerates cellular energy dependent pathways and improves survival after transplantation. The present trial evaluated oxygen persufflation as adjunct in clinical liver preservation.

Patients and Methods

Between 1/11 and 12/13 a total of n=116 adult patients (age: 54(23-68) years, M/F: 70/46), were enrolled in this prospective randomized study. Grafts were randomized to either retrograde O2-persufflation for ≥ 2 hours (O2) or mere cold storage (control). Only liver grafts from donors ≥55 years and/or grafts allocated as rescue offers were included. Primary endpoint was peak-AST level till post-op. day 3. Standard parameters including graft- and patient survival were evaluated as secondary endpoints. Data monitoring and analysis was performed by the local Clinical Trial Center.

Results

Both study groups were comparable except for a longer ICU stay (4 vs. 3 days) of the donors and a higher recipient age (57 vs. 52 years) in the O2-group. S-TNF-α and TNF gene expression in liver tissue 1h after reperfusion was reduced in the O2 group (p<0.05). Median peak-AST values did not differ between the groups (O2: 580 U/l, control: 699 U/l). 2 patients (1.7%) were re-transplanted for PNF/ hepatic artery thrombosis. Three month graft- and patient survival was similar (O2 vs. control: 87.9% vs. 91.5% and 89.5% vs. 91.5%, p=0.50). Substitution of coagulation factors, thrombocyte and/or erythrocyte concentrates and ICU-stay >8 days was increased in controls (p> 0.05). Following discharge 4.7% in the O2 group and 12.4% of the controls were treated for ITBL.

Conclusions

Apart from multiple tendencies in favor for pre-implantation O2-persufflation, this study failed to demonstrate a statistically significant superiority of O2-persufflation. However, due to the overall low incidence of PNF and the fuzzy definition of early allograft dysfunction the relevancy of this finding is unclear.

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Gallinat A, Paul A, Hoyer D, Klein C, Swoboda S, Ose C, Mathe Z, Treckmann J, Minor T. In House Oxygen Persufflation of Cold Stored Livers Versus Simple Cold Storage in Extended Criteria Liver Grafts: Results of a Randomized Controlled Clinical Trial [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/in-house-oxygen-persufflation-of-cold-stored-livers-versus-simple-cold-storage-in-extended-criteria-liver-grafts-results-of-a-randomized-controlled-clinical-trial/. Accessed May 9, 2025.

« Back to 2015 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences