Impact of HMGB-1 SNPs on Comorbidities and Postoperative Complications in Liver Transplant Recipients

N. Tsukiyama¹, Y. Tanaka¹, Y. Imaoka¹, A. Seidakhmetov¹, R. Nakano¹, N. Tanimine¹, D. Marlen¹, M. Ohira², H. Tahara¹, K. Ide¹, H. Ohdan¹

¹Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan, ²Hiroshima University, Hiroshima, Japan

Meeting: 2022 American Transplant Congress

Abstract number: 1562

Keywords: Hypertension, Infection, Liver transplantation, Polymorphism

Topic: Basic Science » Basic Clinical Science » 17 - Biomarkers: Clinical Outcomes

Session Information

Session Name: Biomarkers: Clinical Outcomes

Session Type: Poster Abstract

Date: Tuesday, June 7, 2022

Session Time: 7:00pm-8:00pm

Presentation Time: 7:00pm-8:00pm

Location: Hynes Halls C & D

*Purpose: High-mobility group box 1 (HMGB-1) is an inflammatory mediator which becomes an uncontrollable lethal factor when released in excess from the nucleus or the cell into the extracellular space due to tissue damage or destruction. There have been several reports of retrospective analyses showing that specific single nucleotide polymorphisms (SNPs) on HMGB-1 are associated with the severity of inflammatory diseases, such as sepsis, pneumonia, and rheumatoid arthritis, and with the incidence and prognosis of malignant diseases.

*Methods: This study enrolled 166 living and deceased liver transplant recipients from October 2008 to September 2021. In these patients, SNPs on the HMGB-1 sequence, including rs2249825, rs1045411, rs1412125, and rs1360485, were confirmed by real-time PCR with the Taqman probe and retrospectively compared with the postoperative results.

*Results: While there was no difference in the occurrence of postoperative infections, there was a statistically significant difference in the incidence of bacteremia with the recessive allele of the rs2249825 and rs1045411 SNPs (GG:GC+CC, 21.8%:38.3%, p = 0.038; TT:TC+CC, 24.8%:42.6%, p = 0.031). There was no difference in the incidence of sepsis using the quick Sepsis-related Organ Failure Assessment diagnostic criterion, but there was a statistically significant difference in sepsis-related complications when one or more recessive alleles of the four SNPs were present (43.1%:66.7%, p = 0.012). Patients with recessive alleles in rs2249825, rs1045411, and rs1360485 had higher rates of anti-hypertensive medication before and after transplantation (GG:GC+CC, 18.4%:40.0%, p = 0.004; TT:TC+CC, 23.0%:41.7%, p = 0.016; TT:TC+CC, 26.4%:45.0%, p = 0.02). The inpatient mortality, 1 and 3 year survival, or postoperative malignant complications were not significantly different among the SNP variants.

*Conclusions: Certain SNPs on HMGB-1 may be considered as risk factors for complications in liver transplant patients.

To cite this abstract in AMA style:

Tsukiyama N, Tanaka Y, Imaoka Y, Seidakhmetov A, Nakano R, Tanimine N, Marlen D, Ohira M, Tahara H, Ide K, Ohdan H. Impact of HMGB-1 SNPs on Comorbidities and Postoperative Complications in Liver Transplant Recipients [abstract]. Am J Transplant. 2022; 22 (suppl 3). https://atcmeetingabstracts.com/abstract/impact-of-hmgb-1-snps-on-comorbidities-and-postoperative-complications-in-liver-transplant-recipients/. Accessed May 7, 2025.

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