Impact of Donor Age on Outcomes after Living Donor Liver Transplantation
1Dept of Gastroenterological Sugery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
2Division of Health Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Meeting: 2018 American Transplant Congress
Abstract number: D239
Keywords: Age factors, Graft survival, Hepatocellular carcinoma, Liver transplantation
Session Information
Session Name: Poster Session D: Liver: Living Donors and Partial Grafts
Session Type: Poster Session
Date: Tuesday, June 5, 2018
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Hall 4EF
Background: Liver transplantation (LT) is a curative treatment for decompensated cirrhosis and fulminant hepatitis. Although not a few patients received LT with marginal donor livers (including aged donor livers), the risk associated with donor age remains unclear.
Objective: To investigate the relationship between donor age and outcomes after LT.
Patients and methods: We retrospectively analyzed 117 cases of adult-to-adult living donor liver transplant (LDLT) performed at our institute from March in 1999 to September in 2012. All living liver donors were adults between 20 and 65 years of age. Donor candidates with systemic diseases such as hypertension, diabetes mellitus, or psychiatric disease, and those receiving medications for any systemic disease were strictly excluded. We classified the donors into 2 groups: a younger group (<40 years of age) (n=61) and an older group (≥40 years of age) (n=55).
Results: 1) No significant differences between the younger and older groups were noted in MELD score, graft type, GV/SLV, ABO incompatibility, bleeding amount, or the length of cold ischemic time. However, significant differences were observed in the recipient age (53.2 vs 46.3, P = 0.002), in the length of warm ischemic time (41 vs 46 mins., P = 0.02), and in the presence of acute cellular rejection (21% vs 42%, P = 0.01) between these 2 groups. 2) 5-year survival rate of all 117 cases was 80.4%. The graft survival rates at 1, 3, and 5 years were 91.8%, 85.2%, and 82.0% in the younger group, and 83.6%, 78.2%, and 78.2% in the older group, respectively. There were no significant differences in the survival rate between these two groups (P = 0.45). 3)No significant differences in the survival rate were noted between these two groups for recipients with a graft-to-recipient body weight ratio (GRWR) less than 0.8 (P = 0.8445).
Conclusions:Potential live donors should not be declined on the basis of donor age alone.
CITATION INFORMATION: Hayashi K., Gotoh K., Eguchi H., Iwagami Y., Yamada D., Asaoka T., Noda T., Kawamoto K., Kobayashi S., Umeshita K., Doki Y., Mori M. Impact of Donor Age on Outcomes after Living Donor Liver Transplantation Am J Transplant. 2017;17 (suppl 3).
To cite this abstract in AMA style:
Hayashi K, Gotoh K, Eguchi H, Iwagami Y, Yamada D, Asaoka T, Noda T, Kawamoto K, Kobayashi S, Umeshita K, Doki Y, Mori M. Impact of Donor Age on Outcomes after Living Donor Liver Transplantation [abstract]. https://atcmeetingabstracts.com/abstract/impact-of-donor-age-on-outcomes-after-living-donor-liver-transplantation/. Accessed May 9, 2025.« Back to 2018 American Transplant Congress