ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Impact of Chronic Changes on Preimplantation Biopsy (PBx) on Outcomes after Deceased Donor Kidney Transplantation (DDKTx)

J. Ninan, R. Heilman, M. Smith, J. Harbell, S. S. Nair, C. Jadloweic, H. Khamash, A. Moss, K. S. Reddy

Mayo Clinic, Phoenix, AZ

Meeting: 2020 American Transplant Congress

Abstract number: B-033

Keywords: Biopsy, Graft failure, Graft function, Kidney transplantation

Session Information

Session Name: Poster Session B: Kidney Deceased Donor Selection

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

 Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: The value of PBx is unclear. The aim of this study was to determine the prognostic value of chronic changes on PBx on graft survival and GFR after DDKTx.

*Methods: All DDKTx recipients transplanted at our center between 1/2013 and 8/2018 were included. Pathology data from all PBx reports read at out center was collected. A modified Remuzzi(RU) score was used to quantify the chronic changes on PBx(glomerular sclerosis, interstitial fibrosis, arterial narrowing). The low RU sum group had a sum of 0-3(low sum) and the high RU sum group had a sum of 4-8(high sum). The outcomes were graft survival and eGFR at 1 year(yr).

*Results: The cohort size was 1,198. PBx was available in 758(63.3%). The median follow up for the cohort was 3.1 years. The median number of glomeruli in the PBx was 48(IQR 30-70). There was adequate data to calculate the RU score in 704 biopsies. The median RU sum score was 2(range 0-8) and 195(22.7%) had a high sum. The median(IQR) KDPI was 78(60-90) in the high sum and 53(34-75) in the low sum(P<.0001). Graft survival was lower in the high sum group(p=0.03).

 border=

When stratified into two cohorts; KDPI>85 vs ≤85, the difference in graft survival was no longer apparent.

 border=

In a Cox model including the RU sum and the KDPI as a continuous variable, the high sum group was not a risk factor for graft survival(1.20, 95% CI 0.80-1.79). The eGFR at 1 yr was lower and the % with eGFR <30 at 1 yr was higher in the high sum group in the cohort with donor KDPI≤85. This difference was not as apparent in the cohort with donor KDPI>85 (table).

KDPI<85 KDPI<85 KDPI>85
Low sum High sum p Low sum High sum p
eGFR 1 yr 58.3 (20.3) 49.7 (17.8) 0.0002 42.0 (14.3) 38.2 (12.9) 0.21
eGFR<30 (%) 6.1 12.6 0.047 22.0 27.3 0.57

*Conclusions: Chronic changes on PBx correlated with lower mid-term graft survival and lower GFR at 1yr; however, after controlling for KDPI, RU sum no longer was a risk factor for graft survival. Our data suggests that PBx could be of value in the recipient selection for select KDPI ≤85 as a higher RU sum correlated with lower GFR at 1 yr.

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Ninan J, Heilman R, Smith M, Harbell J, Nair SS, Jadloweic C, Khamash H, Moss A, Reddy KS. Impact of Chronic Changes on Preimplantation Biopsy (PBx) on Outcomes after Deceased Donor Kidney Transplantation (DDKTx) [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/impact-of-chronic-changes-on-preimplantation-biopsy-pbx-on-outcomes-after-deceased-donor-kidney-transplantation-ddktx/. Accessed May 10, 2025.

« Back to 2020 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences