ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Fibrosis, Not Quantitative NGAL-Staining, in Day-10 Protocol Biopsies Predicts Prolonged Duration of Functional Delayed Graft Function in a Cohort of DCD Kidney Transplant Recipients

J. Bank,1 M. Reinders,1 M. Mallat,1 N. Schlagwein,1 S. van der Kooij,1 D. van Gijlswijk,1 I. Bajema,2 C. van Kooten,1 H. de Fijter.1

1Nephrology, LUMC, Leiden, Netherlands
2Pathology, LUMC, Leiden, Netherlands.

Meeting: 2015 American Transplant Congress

Abstract number: C286

Keywords: Donors, Fibrosis, Graft function, marginal, Protocol biopsy

Session Information

Session Name: Poster Session C: Translational Biomarkers and Immune Monitoring

Session Type: Poster Session

Date: Monday, May 4, 2015

Session Time: 5:30pm-6:30pm

 Presentation Time: 5:30pm-6:30pm

Location: Exhibit Hall E

Introduction: Extended criteria deceased kidneys are associated with prolonged delayed graft function and worse patient survival. Therefore it is important to identify factors in marginal donors that affect kidney quality and function. We validated a reported donor scoring system from donation after brain death (DBD) donors in a cohort of circulatory death (DCD) transplant recipients. In addition, we related marginal donor scores, protocol biopsy characteristics and fractional NGAL excretion (FeNGAL) to duration of functionally defined delayed graft function (f-DGF) and one-year renal function (eGFR). Methods: 92 consecutive DCD transplant recipients were included, all receiving IL2-RB induction and triple maintenance therapy (CNI, steroids, MMF). Day-10 protocol biopsies were scored according to the Banff criteria and ATN characteristics. In addition, NGAL was stained and %-surface positivity quantified with image-J. Day-10 FeNGAL was calculated using serum and urinary NGAL. Statistical analysis included uni- and multivariable binary logistic regression and ROC curves. Results: In DCD recipients the previously reported marginal donor scoring system was also associated with impaired one-year GFR (p<0.0005) and duration of f-DGF (p=0.002). Multivariable analysis identified donor age, f-DGF, and mismatch degree (2DR or 1DR/2B) as independent risk factors for inferior one-year GFR. In ROC analysis this model predicted GFR ≤40ml/min with an AUC of 0.87 (0.76-0.98). In histology only IF/TA scores and denudation were associated with impaired one-year GFR, increasing the AUC from 0.87 to 0.94 (0.88-1.00). In the analysis of patients with moderate (8-20 days) and severe (≥21 days) f-DGF only IF/TA score remained an independent predictor for severe f-DGF. Although NGAL staining did not discriminate these groups, day-10 FeNGAL tended to differentiate between moderate and severe f-DGF (p=0.064). Moreover FeNGAL and duration of f-DGF were strongly correlated (R=0.91). Conclusion: Also in DCD recipients a high clinical donor score was associated with inferior one-year renal function. The most important predictor for prolonged f-DGF was IF/TA. In addition, sequential fractional NGAL excretions may serve as a non-invasive marker to guide management in patients with marginal donor kidneys and delayed function.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Bank J, Reinders M, Mallat M, Schlagwein N, Kooij Svander, Gijlswijk Dvan, Bajema I, Kooten Cvan, Fijter Hde. Fibrosis, Not Quantitative NGAL-Staining, in Day-10 Protocol Biopsies Predicts Prolonged Duration of Functional Delayed Graft Function in a Cohort of DCD Kidney Transplant Recipients [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/fibrosis-not-quantitative-ngal-staining-in-day-10-protocol-biopsies-predicts-prolonged-duration-of-functional-delayed-graft-function-in-a-cohort-of-dcd-kidney-transplant-recipients/. Accessed May 30, 2025.

« Back to 2015 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences