Articles tagged "Fibrosis"

2020 American Transplant Congress
Persistent Fibrinolysis Shutdown in Liver Transplant Recipients is Associated with Early Allograph Dysfunction
H. B. Moore¹, T. Nydam¹, J. Pomposelli¹, C. Walker¹, A. Schulick¹, R. Choudhury¹, H. Yaffe¹, M. Adams², M. Cohen³, E. Pomfret¹
¹University of Colorado, Aurora, CO, ²Childrens Hospital, Aurora, CO, ³Denver Health Medical Center, Denver, CO
*Purpose: Early allograph dysfunction (EAD) in liver transplantation has been attributed to microvascular thrombosis. Treating grafts at risk of EAD with tissue plasminogen activator (tPA)…
2020 American Transplant Congress
Automatic Quantification of Interstitial Fibrosis in Renal Allograft
J. Hogan¹, J. Vizcarra², M. A. Tageldin², L. A. Cooper³, D. A. Gutman², A. B. Farris⁴
¹Transplant Research Center, Department of Surgery, Emory University, Atlanta, GA, ²Computer Science Department, Emory University, Atlanta, GA, ³Pathology Department, Northwestern University, Evanston, IL, ⁴Pathology Department, Emory University, Atlanta, GA
*Purpose: Renal allografts are typically assessed by pathologists using the Banff classification with known interobserver variability. We previously demonstrated the utility of image analysis in…
2020 American Transplant Congress
Gross Morphological Score for Deceased Donor Kidneys Can Predict Delayed Graft Function in Kidney Transplant Recipients
M. Mandurah, M. A. Levine, A. Sener, P. Luke
Department of Kidney Transplantation, London Health Sciences Center, London, ON, Canada
*Purpose: Both microscopy and kidney donor profile index (KDPI) scoring systems have been used to predict kidney transplant outcomes. Utilizing gross renal morphology, we designed…
2020 American Transplant Congress
Bortezomib Exhibits Therapeutic Implication in Renal Interstitial Fibrosis after Kidney Transplantation by Inhibiting Akt-mTOR-P70S6K-Smurf2 Pathway and Stabilizing IκBα Protein
C. Suo, Z. Gui, Z. Wang, J. Zhou, M. Zheng, H. Chen, S. Fei, L. Sun, X. Zhang, M. Gu, R. Tan
Jiangsu Province Hospital, Nanjing, China
*Purpose: Allograft interstitial fibrosis and fibrogenesis significantly exacerbate the progression of chronic allograft disease (CAD) and are essential therapeutic targets. Epithelial‐mesenchymal transition (EMT) is recognized…
2020 American Transplant Congress
Autophagy Attenuates Renal Allograft Interstitial Fibrosis by Regulating the EndMT Induced by TNF-α
Z. Gui, C. Suo, Z. Wang, S. Fei, Z. Han, J. Tao, H. Chen, L. Sun, X. Ju, R. Tan, M. Gu
Jiangsu Province Hospital, Nanjing, China
*Purpose: Kidney interstitial fibrosis is a significant cause of allograft failure in kidney transplantation. Autophagy is a self-digestive process that eliminates impaired or aged proteins…
2020 American Transplant Congress
Divergent Molecular Pathways Underlie the Evolution of Allograft Fibrosis in Two Mouse Models of Chronic Lung Allograft Dysfunction
T. Watanabe, J. Allen, K. Boonstra, Z. Guan, K. Bei, S. Keshavjee, J. Yeung, T. Martinu, S. Juvet
Latner Thoracic Surgery Research Laboratories, Toronto Lung Transplant Program / University Health Network, Toronto, ON, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx) is potentiated by activation of the innate immune system and occurs in two patterns: diffuse…
2020 American Transplant Congress
Src Induces Endothelial-to-Mesenchymal Transition and Renal Allograft Fibrosis via Promoting WNT/β-catenin Pathway
W. Zijie, Z. Gui, M. Zheng, Z. Han, J. Tao, H. Chen, L. Sun, X. Ju, R. Tan, M. Gu
Jiangsu Province Hospital, Nanjing, China
*Purpose: Endothelial-to-mesenchymal(EndMT)is recognized as an important source of myofibroblasts contributing to the pathogenesis of allograft interstitial fibrosis in our previous studies. Increased proto-oncogene tyrosine-protein kinase…
2020 American Transplant Congress
The Impact of Thy1 Expression of Fibroblast for Chronic Lung Allograft Dysfunction
A. Hata¹, Y. Guo¹, D. Li¹, Z. Mei¹, A. Manafi¹, A. Banerjee¹, B. Mahgoub¹, T. H. Barker², A. S. Krupnick¹
¹Surgery, University of Virginia, Charlottesville, VA, ²Biomedical Engineering, University of Virginia, Charlottesville, VA
*Purpose: Chronic lung allograft dysfunction (CLAD) result from excessive immune activation and excessive collagen deposition by fibroblasts within the lung parenchyma or airway.Bronchiolitis obliterans (OB)…
2020 American Transplant Congress
Elucidating the Genetic Background of End Stage Renal Disease of Unknown Aetiology in Patients Listed for Kidney Transplantation
E. Leenen¹, B. Beck², A. Joerres¹, A. Weidemann¹
¹Department of Medicine I - Nephrology, Transplantation & Medical Intensive Care, Medical Center Cologne-Merheim, Cologne, Germany, ²Institute of Human Genetics University Hospital Cologne, Medical Center Cologne-Merheim, Cologne, Germany
*Purpose: The prevalence of end stage renal disease (ESRD) of unknown aetiology in adult patients accounts for almost 20% of all dialysis patients in Europe.…
2020 American Transplant Congress
Development of DSA Class II is Associated with Immunosuppressive Monotherapy and Increased Risk for Graft Fibrosis, Chronic Rejection and Graft Loss
M. Sterneck¹, B. Sultani¹, A. Ozga², S. Weidemann³, J. Hermann⁴, E. Grabhorn⁵, U. Herden⁶, L. Fischer⁶
¹University Medical Center Hamburg Eppendorf, Hamburg, Germany, ²Insitute of Medical Biometry, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ³Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ⁴Pediatric Radiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ⁵Pediatric Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ⁶Transplant Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
*Purpose: Recent studies have suggested a negative impact of class 2 DSA on short term outcome of OLT recipients. The aim of this study was…