ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Fibrosis"

  • 2022 American Transplant Congress

    Utility of Urinary CTGF as a Biomarker of Progressive Allograft Dysfunction in Pediatric Renal Transplant Recipients

    L. Sheward1, J. Wedel1, N. Rodig1, A. Kho1, T. Blydt-Hansen2, R. B. Mannon3, D. M. Briscoe1

    1Boston Children's Hospital, Boston, MA, 2BC Children's Hospital, Vancouver, BC, Canada, 3University of Nebraska Medical Center, Omaha, NE

    *Purpose: Previous reports from a number of studies indicate that renal allograft recipients who have inflammatory infiltrates within areas of interstitial fibrosis with tubular atrophy…
  • 2022 American Transplant Congress

    B and Plasma Cell Populations Drive Chronic Rejection After Lung Transplantation

    M. Bueno1, N. F. Smirnova2, K. Riemondy3, P. Suresh1, M. Brown1, X. Wang1, S. Collins4, J. Sembrat1, M. Koenigshoff1, M. Snyder1, J. McDyer1, O. Eickelberg1

    1Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 2I2MC, INSERM UMR1297, Toulouse, France, 3Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, 4Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO

    *Purpose: Chronic lung allograft dysfunction (CLAD) remains the major determinant of morbidity and mortality post-lung transplantation (LTx). Bronchiolitis obliterans syndrome (BOS) is the most prevalent…
  • 2022 American Transplant Congress

    Autophagy is an Important Factor in the Development of Fibrosis Following Renal Injury; Implications for Post-Transplant IFTA

    R. Lopez-Soler1, X. Ding2, Q. Zang3

    1Tansplant, Surgery, Edward Hines VA Medical Center, Hines, IL, 2Pathology, Loyola University Medical Center, Maywood, IL, 3Surgery, Loyola University Medical Center, Maywood, IL

    *Purpose: Interstitial Fibrosis and Tubular Atrophy (IFTA) is the most common cause of long-term graft failure following renal transplant. There is currently no effective therapy.…
  • 2022 American Transplant Congress

    Everolimus Alleviates Renal Allograft Interstitial Fibrosis by Inhibiting Epithelial to Mesenchymal Transition Not Only via Inducing Autophagy but Also via Stabilizing iκB-α

    Z. Gui1, W. Zijie2, M. Zheng3, M. Gu1, R. Tan3

    1Department of Urology, The Second Affiliated Hospital with Nanjing Medical University, Nanjing, China, 2Jiangsu Province Hospital, Nanjing, China, 3Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China

    *Purpose: Chronic allograft dysfunction (CAD) is the major cause of late graft loss in long-term renal transplantation. In our previous study, we found Epithelial-mesenchymal transition…
  • 2022 American Transplant Congress

    Cell-free Amniotic Fluid Reduces Liver Inflammation And Fibrosis

    F. Ditmars1, C. Bowen1, N. Liu1, K. L. Pereira de Castro1, J. Johnson1, M. Kueht1, A. Saad2, H. L. Stevenson3, J. Fair1, W. S. Fagg1

    1Surgery, University of Texas Medical Branch, Galveston, TX, 2Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, 3Pathology, University of Texas Medical Branch, Galveston, TX

    *Purpose: Effective interventions for hepatic inflammation and fibrosis remain a dire unmet need in transplant medicine. Cell-free amniotic fluid (AF) represents a potential alternative to…
  • 2022 American Transplant Congress

    Deep Learning Identifies Arterial Intimal Fibrosis in Kidney Transplant Biopsies

    K. Liu1, Z. Yi2, S. Ward3, F. Salem3, W. Zhang2

    1Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY, 2Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 3Molecular and Cell Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY

    *Purpose: Arterial intimal fibrosis (AIF) is the excessive fibrotic tissue formation in the intima of arteries indicative of poor graft function after kidney transplant. Visual…
  • 2022 American Transplant Congress

    Targeted Delivery of Costimulation Inhibitor to Lymph Nodes Promotes Transplant Tolerance via Fibroblastic Reticular Cells

    J. Zhao1, S. Jung1, X. Li1, H. Zhang1, S. Movahedi1, V. Kasinath1, M. Uehara1, J. Azzi1, P. Sage1, S. Tullius1, J. S. Bromberg2, R. Abdi1

    1Brigham and Women's Hospital, Boston, MA, 2University of Maryland School of Medicine, Baltimore, MD

    *Purpose: The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Fibroblastic reticular cells (FRCs), the prominent cells of the…
  • 2022 American Transplant Congress

    Preclinical Evaluation of Functional Survival of Stem Cell Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression

    M. C. Poznansky

    Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestwon, MA

    *Purpose: Human stem cell-derived islet-like cells (SC-islets) represent a sustainable source for beta-cell replacement to achieve a functional cure for type 1 diabetes. We previously…
  • 2022 American Transplant Congress

    More Than Just Drain Pipes, Pulmonary Lymphatics Play a Pivotal Role in the Development of Bronchiolitis Obliterans Syndrome

    L. Wang1, R. Han2, H. Outtz Reed3, W. W. Hancock2

    1Childrens Hospital of Phila, Philadelphia, PA, 2Children's Hospital of Philadelphia, Philadelphia, PA, 3Weill Cornell, New York, NY

    *Purpose: Chronic allograft dysfunction (CLAD) remains a major determinant of the generally poor long-term outcome of lung transplantation compared to that of other solid organ…
  • 2022 American Transplant Congress

    Kidney Transplant Alone Recipients with Advanced Liver Disease Have Similar Outcomes to Those without Advanced Liver Disease

    R. R. Nathani, S. M. Rutledge, C. Villarroel, R. Shapiro, G. Y. Im

    Icahn School of Medicine at Mount Sinai, New York, NY

    *Purpose: The prevalence of concomitant liver disease (CLD) in patients with ESRD is reported to be 7-40%. Safety of kidney transplant alone (KTA) in those…
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