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American Transplant Congress abstracts

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Articles tagged "Fibrosis"

  • 2020 American Transplant Congress

    Persistent Fibrinolysis Shutdown in Liver Transplant Recipients is Associated with Early Allograph Dysfunction

    H. B. Moore1, T. Nydam1, J. Pomposelli1, C. Walker1, A. Schulick1, R. Choudhury1, H. Yaffe1, M. Adams2, M. Cohen3, E. Pomfret1

    1University of Colorado, Aurora, CO, 2Childrens Hospital, Aurora, CO, 3Denver Health Medical Center, Denver, CO

    *Purpose: Early allograph dysfunction (EAD) in liver transplantation has been attributed to microvascular thrombosis. Treating grafts at risk of EAD with tissue plasminogen activator (tPA)…
  • 2020 American Transplant Congress

    Automatic Quantification of Interstitial Fibrosis in Renal Allograft

    J. Hogan1, J. Vizcarra2, M. A. Tageldin2, L. A. Cooper3, D. A. Gutman2, A. B. Farris4

    1Transplant Research Center, Department of Surgery, Emory University, Atlanta, GA, 2Computer Science Department, Emory University, Atlanta, GA, 3Pathology Department, Northwestern University, Evanston, IL, 4Pathology Department, Emory University, Atlanta, GA

    *Purpose: Renal allografts are typically assessed by pathologists using the Banff classification with known interobserver variability. We previously demonstrated the utility of image analysis in…
  • 2020 American Transplant Congress

    Gross Morphological Score for Deceased Donor Kidneys Can Predict Delayed Graft Function in Kidney Transplant Recipients

    M. Mandurah, M. A. Levine, A. Sener, P. Luke

    Department of Kidney Transplantation, London Health Sciences Center, London, ON, Canada

    *Purpose: Both microscopy and kidney donor profile index (KDPI) scoring systems have been used to predict kidney transplant outcomes. Utilizing gross renal morphology, we designed…
  • 2020 American Transplant Congress

    Bortezomib Exhibits Therapeutic Implication in Renal Interstitial Fibrosis after Kidney Transplantation by Inhibiting Akt-mTOR-P70S6K-Smurf2 Pathway and Stabilizing IκBα Protein

    C. Suo, Z. Gui, Z. Wang, J. Zhou, M. Zheng, H. Chen, S. Fei, L. Sun, X. Zhang, M. Gu, R. Tan

    Jiangsu Province Hospital, Nanjing, China

    *Purpose: Allograft interstitial fibrosis and fibrogenesis significantly exacerbate the progression of chronic allograft disease (CAD) and are essential therapeutic targets. Epithelial‐mesenchymal transition (EMT) is recognized…
  • 2020 American Transplant Congress

    Autophagy Attenuates Renal Allograft Interstitial Fibrosis by Regulating the EndMT Induced by TNF-α

    Z. Gui, C. Suo, Z. Wang, S. Fei, Z. Han, J. Tao, H. Chen, L. Sun, X. Ju, R. Tan, M. Gu

    Jiangsu Province Hospital, Nanjing, China

    *Purpose: Kidney interstitial fibrosis is a significant cause of allograft failure in kidney transplantation. Autophagy is a self-digestive process that eliminates impaired or aged proteins…
  • 2020 American Transplant Congress

    Divergent Molecular Pathways Underlie the Evolution of Allograft Fibrosis in Two Mouse Models of Chronic Lung Allograft Dysfunction

    T. Watanabe, J. Allen, K. Boonstra, Z. Guan, K. Bei, S. Keshavjee, J. Yeung, T. Martinu, S. Juvet

    Latner Thoracic Surgery Research Laboratories, Toronto Lung Transplant Program / University Health Network, Toronto, ON, Canada

    *Purpose: Chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx) is potentiated by activation of the innate immune system and occurs in two patterns: diffuse…
  • 2020 American Transplant Congress

    Src Induces Endothelial-to-Mesenchymal Transition and Renal Allograft Fibrosis via Promoting WNT/β-catenin Pathway

    W. Zijie, Z. Gui, M. Zheng, Z. Han, J. Tao, H. Chen, L. Sun, X. Ju, R. Tan, M. Gu

    Jiangsu Province Hospital, Nanjing, China

    *Purpose: Endothelial-to-mesenchymal(EndMT)is recognized as an important source of myofibroblasts contributing to the pathogenesis of allograft interstitial fibrosis in our previous studies. Increased proto-oncogene tyrosine-protein kinase…
  • 2020 American Transplant Congress

    The Impact of Thy1 Expression of Fibroblast for Chronic Lung Allograft Dysfunction

    A. Hata1, Y. Guo1, D. Li1, Z. Mei1, A. Manafi1, A. Banerjee1, B. Mahgoub1, T. H. Barker2, A. S. Krupnick1

    1Surgery, University of Virginia, Charlottesville, VA, 2Biomedical Engineering, University of Virginia, Charlottesville, VA

    *Purpose: Chronic lung allograft dysfunction (CLAD) result from excessive immune activation and excessive collagen deposition by fibroblasts within the lung parenchyma or airway.Bronchiolitis obliterans (OB)…
  • 2020 American Transplant Congress

    Elucidating the Genetic Background of End Stage Renal Disease of Unknown Aetiology in Patients Listed for Kidney Transplantation

    E. Leenen1, B. Beck2, A. Joerres1, A. Weidemann1

    1Department of Medicine I - Nephrology, Transplantation & Medical Intensive Care, Medical Center Cologne-Merheim, Cologne, Germany, 2Institute of Human Genetics University Hospital Cologne, Medical Center Cologne-Merheim, Cologne, Germany

    *Purpose: The prevalence of end stage renal disease (ESRD) of unknown aetiology in adult patients accounts for almost 20% of all dialysis patients in Europe.…
  • 2020 American Transplant Congress

    Development of DSA Class II is Associated with Immunosuppressive Monotherapy and Increased Risk for Graft Fibrosis, Chronic Rejection and Graft Loss

    M. Sterneck1, B. Sultani1, A. Ozga2, S. Weidemann3, J. Hermann4, E. Grabhorn5, U. Herden6, L. Fischer6

    1University Medical Center Hamburg Eppendorf, Hamburg, Germany, 2Insitute of Medical Biometry, University Medical Center Hamburg Eppendorf, Hamburg, Germany, 3Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany, 4Pediatric Radiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany, 5Pediatric Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany, 6Transplant Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany

    *Purpose: Recent studies have suggested a negative impact of class 2 DSA on short term outcome of OLT recipients. The aim of this study was…
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