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End-Hypothermic Oxygenated Machine Perfusion after Static Cold Storage versus Static Cold Storage Alone in Kidneys from Extended Criteria Brain-Dead Donors: An International Randomized Controlled Trial

P. Husen1, C. Boffa2, I. Jochmans3, C. Krikke4, L. Davies2, H. Hofker4, J. Pirenne3, R. Ploeg2, A. Paul1

1General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany, 2Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 3University Hospitals Leuven, Leuven, Belgium, 4University Medical Center Groningen, Groningen, Netherlands

Meeting: 2020 American Transplant Congress

Abstract number: LB-6

Keywords: Donors, marginal, Graft survival, Kidney transplantation, Preservation

Session Information

Session Name: Late Breaking Oral Abstract

Session Type: Oral Abstract Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:45pm

 Presentation Time: 4:15pm-4:27pm

Location: Virtual

*Purpose: A prospective, randomized, single-blinded, multicenter trial comparing the effect of short-term ‘in house’ oxygenated hypothermic machine preservation (End-HMPO2) following static cold storage (SCS) versus SCS alone on clinical outcome in expanded criteria donor (ECD) kidneys from brain-dead donors (DBD).

*Methods: In a non-paired design, kidneys from ECD donors were assigned to either SCS alone or SCS followed by End-HMPO2 in the recipient center prior to implantation. Minimum machine preservation time was 120min. Primary endpoint was 1-year graft survival, with delayed graft function, primary non-function, acute rejection, eGFR, as well as patient survival as secondary endpoints.

*Results: Centers in Belgium, Germany, Hungary, the Netherlands and the UK randomized 305 kidneys [median donor age 64y (range 50-84)], of which 262 kidneys (127 End-HMPO2, 135 SCS) were successfully transplanted [median recipient age 63y (22-81.2)]. Median cold ischaemia time was 13.2h (range 5.1-28.7) in the End-HMPO2 group and 12.9h (4-29.2) in the SCS group; median duration of End-HMPO2 was 4.7h (0.8-17.1). One year graft survival was 92.1% (N=117) in the End-HMPO2 group vs. 93.3% (N=126) in the SCS group (95% CI: -7.5-5.1, p=0.7). The secondary endpoint analysis showed similar results in both Groups.

*Conclusions: Reconditioning of ECD kidneys from DBD donors using ‘short-term‘ oxygenated hypothermic machine perfusion prior to transplantation after a period of static cold storage does not lead to improved graft survival or function when compared to simple static cold storage alone.

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To cite this abstract in AMA style:

Husen P, Boffa C, Jochmans I, Krikke C, Davies L, Hofker H, Pirenne J, Ploeg R, Paul A. End-Hypothermic Oxygenated Machine Perfusion after Static Cold Storage versus Static Cold Storage Alone in Kidneys from Extended Criteria Brain-Dead Donors: An International Randomized Controlled Trial [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/end-hypothermic-oxygenated-machine-perfusion-after-static-cold-storage-versus-static-cold-storage-alone-in-kidneys-from-extended-criteria-brain-dead-donors-an-international-randomized-controlled-tria/. Accessed May 11, 2025.

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