Session Time: 2:30pm-4:00pm
Presentation Time: 3:18pm-3:30pm
Location: Room 206
Kidney transplant recipients (KTR) receiving sirolimus accrue fewer skin cancers than KTR receiving calcineurin inhibitor (CNI) based immunosuppression, potentially due to effects of sirolimus and CNI on skin-infiltrating T cells.
Peripheral blood samples and skin biopsies from sun exposed and non sun exposed areas of the arm were collected from three groups of patients (all n=15): 1) KTR receiving sirolimus (2) KTR receiving CNI and (3) non-immunosuppressed patients with chronic kidney disease (CKD). The immunophenotype of T-cells in skin and blood were characterised by multicolor flow cytometry.
The absolute number of CD8 memory cells (CD45RO+RA–) was greater in sun exposed skin in sirolimus and CNI treated KTRs compared to CKD patients (p <0.01 and <0.05 respectively) The proportion of CD4+ T cells with a T-reg phenotype (CD127loCD25hi) was higher in non sun-exposed skin in sirolimus compared to CNI treated KTRs (<0.05) In sirolimus treated patients Treg and memory CD8 T-cells showed poor correlation between blood and sun exposed skin (r=-0.22, 0.21 respectively). Treg and memory CD8 T-cells in CNI treated patients had better correlation between blood and sun exposed skin (r=0.8 and 0.35 respectively)
Type of immunosuppressive treatment and sun exposure modify the frequency of Treg and memory CD8+T cells in the skin of KTRs and influence correlation in immune cell numbers between blood and skin.
CITATION INFORMATION: Burke M, Nahum L, Isbel N, Carroll R, Soyer H, Francis R, Bridge J, Staatz C, Wells J. Effects of Immunosuppression and Sun Exposure on Immune Cell Populations in Skin and Blood of Kidney Transplant Recipients. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Burke M, Nahum L, Isbel N, Carroll R, Soyer H, Francis R, Bridge J, Staatz C, Wells J. Effects of Immunosuppression and Sun Exposure on Immune Cell Populations in Skin and Blood of Kidney Transplant Recipients. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/effects-of-immunosuppression-and-sun-exposure-on-immune-cell-populations-in-skin-and-blood-of-kidney-transplant-recipients/. Accessed March 3, 2021.
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