ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Sirolimus (SLR)"

  • 2020 American Transplant Congress

    Conversion to Sirolimus to Prevent Recurrent Cytomegalovirus Infection/Disease: A Prospective and Randomized Trial

    L. Almeida Viana, M. Pontello Cristelli, G. Basso, D. Wagner Castro Lima Santos, M. Taver Costa Dantas, Y. Cardoso Dreige, L. Damasceno, M. Rika Nakamura, H. Tedesco-Silva, J. Medina-Pestana

    Hospital do Rim - UNIFESP, São Paulo, Brazil

    *Purpose: Recurrent cytomegalovirus (CMV) infection occurs in 30-35% of kidney transplant recipients after completion of treatment and/or preemptive therapy. There is no consensus on the…
  • 2020 American Transplant Congress

    Immuno-Modulation of Primed Xenogeneic T Cell Response by mTOR Blockade of T Cells and Porcine Endothelial Cells

    S. Li, A. Kirk, H. Xu

    Surgery, Duke University, Durham, NC

    *Purpose: Porcine vascular endothelial cells (PECs) play a central role in xeno-recognition and costimulation. The objectives of this study were to characterize the immuno-phenotype of…
  • 2020 American Transplant Congress

    Sirolimus Combined with Low-Dose Calcineurin Inhibitor in Kidney Transplant Recipients from Expanded Criteria Donors

    J. Zhang, J. Lin, Y. Tian, W. Sun, L. Zhang

    Beijing Friendship Hospital, Capital Medical University, Beijing, China

    *Purpose: To evaluate the efficacy and safety of conversion from calcineurin inhibitor-based immunosuppressive regimen to sirolimus combined with low-dose calcineurin inhibitor in recipients with abnormal…
  • 2020 American Transplant Congress

    The Impact of Sirolimus on Weight Gain Post Heart Transplant

    S. M. Gore, C. E. Raphael, K. Mara, C. Arendt, A. L. Clavell, S. A. Bernard

    Mayo Clinic, Rochester, MN

    *Purpose: Obesity is common after heart transplant (HT), resulting in increased risk of new onset diabetes, all-cause and cardiovascular mortality and graft failure. Immunosuppressants (ISN)…
  • 2020 American Transplant Congress

    Long Term Effect of Tacrolimus Conversion to Sirolimus with Prednisone-Free Regimen in Kidney Allograft Outcomes: A Dynamic Analysis of Graft Survival Using Joint Modeling

    S. H. Park1, B. Ho1, K. Guo1, L. Zhao2, V. Mas3, J. Leventhal4, L. Gallon1

    1Transplant Nephrology, Northwestern University, Chicago, IL, 2Preventive Medicine, Northwestern University, Chicago, IL, 3University of Tennesse, Memphis, TN, 4Transplant Surgery, Northwestern University, Chicago, IL

    *Purpose: Findings on long-term impacts of the mammalian target of rapamycin inhibitor inhibitors on kidney allograft are scarce and mixed. A joint modeling approach can…
  • 2019 American Transplant Congress

    Comparison of Initial Sirolimus (SRL) and Everolimus (EVR) Exposure Patterns in Kidney Transplant Recipients

    C. Rosso Felipe, L. Viana, M. Pontello Cristelli, M. Nakamura, L. Ramagnoli, S. Braga, V. Lima, A. Carnevalle, D. Casarini, J. Medina Pestana, H. Tedesco Silva Junior

    Hospital do Rim, Nephrology Division, EPM - UNIFESP, São Paulo, Brazil

    *Purpose: Despite distinct pharmacokinetic properties, SRL and EVR bind to the same intracellular target protein, suggesting that equivalent blood concentrations may exert similar pharmacodynamic effect.*Methods:…
  • 2019 American Transplant Congress

    Slowed Progression of Maximal Intimal Thickening by Intravascular Ultrasound after Initiation of Sirolimus

    A. Putschoegl1, K. Campbell1, M. Everitt1, S. Miyamoto1, B. Pietra2, S. Auerbach1

    1Children's Hospital Colorado, Aurora, CO, 2University of Florida Health, Gainesville, FL

    *Purpose: Evidence in adult heart transplant (HT) patients (pt) shows that initiating sirolimus (SRL) slows progression of cardiac allograft vasculopathy (CAV) measured by intravascular ultrasound…
  • 2019 American Transplant Congress

    Clinical Outcomes of Using mTOR Inhibitors with Reduced Dose of Calcineurin Inhibitors in Lung Transplant Recipients: A Single Center Experience

    M. Frawley1, J. Leedy1, A. James1, A. Salter1, V. Rusanov2

    1Department of Pharmacy, UAB Hospital, Birmingham, AL, 2Division of Pulmonary, Allergy, and Critical Care Medicine, UAB Hospital, Birmingham, AL

    *Purpose: The use of mammalian target of rapamycin inhibitors (mTORi) in cardiothoracic transplantation has significantly increased over the past decade. Several recent clinical trials have…
  • 2019 American Transplant Congress

    mTOR Inhibitors Associated with Higher Cardiovascular Adverse Events – A Large Population Database Analysis

    V. N. Nguyen1, R. Abagyan2, S. Tsunoda2

    1Pharmacy, UC San Diego Health, San Diego, CA, 2Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA

    *Purpose: Our study aimed to compare the adverse events (AEs) of tacrolimus to mammalian target of rapamycin (mTOR) inhibitors in solid organ transplant patients.*Methods: Our…
  • 2019 American Transplant Congress

    Impact of Everolimus Therapy on HIV Persistence and Gene Expression in Transplant Patients

    A. Zarinsefat1, C. Schreiner1, C. Cameron2, S. Chu1, M. P. Busch1, T. Liegler1, S. G. Deeks1, T. J. Henrich1, P. G. Stock1

    1UC San Francisco, San Francisco, CA, 2Case Western Reserve University, Cleveland, OH

    *Purpose: mTOR is a key regulatory kinase that controls cell-cycle progression. mTOR inhibitors have been shown to reduce expression of CCR5 and promote viral transcriptional…
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