ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Delayed Induction of Mixed Chimerism Permits Kidney-Induced Cardiac Allograft Tolerance to be Applied to Recipients of Cadaveric Organs.

M. Tonsho,1 G. Benichou,1 R. Yu,1 S. Boskovic,1 R. Colvin,1,2 E. Farkash,2 R.-N. Smith,2 J. Allan,1,4 A. Cosimi,1 T. Kawai,1,3 J. Madsen.1,4

1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA
2Department of Pathology, Massachusetts General Hospital, Boston, MA
3Department of Surgery, Massachusetts General Hospital, Boston, MA
4Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA.

Meeting: 2016 American Transplant Congress

Abstract number: 478

Keywords: Allorecognition, Immunogenicity, Primates, Stem cells

Session Information

Date: Tuesday, June 14, 2016

Session Name: Concurrent Session: Bone Marrow Transplantation and Chimerism: Animal Models

Session Time: 4:30pm-6:00pm

 Presentation Time: 5:06pm-5:18pm

Location: Room 313

Related Abstracts
  • Renal Allograft Tolerance Can Be Achieved in Non-Human Primates Via Delayed Mixed-Hematopoietic Chimerism and Alefacept Treatment
  • Immune Tolerance Monitoring in Renal Allograft Tolerance Induced by Transient Mixed Chimerism in Nonhuman Primates and Humans.

(BACKGROUND)

Cardiac tolerance in nonhuman primates (NHPs) has been induced for the first time by kidney co-transplantation in combination with donor bone marrow infusion when the conditioning protocol is started six days before transplantation. However, this strategy precludes the use of cadaveric donors. Here, we investigated whether delaying the induction of mixed chimerism until four months post heart and kidney co-transplantation would achieve the same stable state of tolerance.

(METHODS)

Allogeneic heart and kidneys from the same donor were co-transplanted in NHPs treated with tacrolimus, mycophenolate mofetil and methylprednisolone. After four months, immunosuppression was stopped and each recipient underwent bone marrow transplantation with frozen cells from the organ donor. They also received nonmyeloablative conditioning consisting of 3 Gy total body irradiation, 7 Gy local thymic irradiation, anti-thymocyte globulin, anti-CD154 mAb, anti-CD8 mAb and a 28 day course of cyclosporine. Control animals underwent the same treatment but received an isolated heart transplant.

(RESULTS)

Recipients of combined heart and kidney transplants (n=3) achieved long-term survival of both allografts (>547, >588, >1093 days) with no evidence of acute or chronic rejection. Remarkably, tolerance of the cardiac allograft was maintained in one recipient even after the donor kidney was removed. Delayed tolerance induction was associated with donor-specific T cell hypo-/unresponsiveness, the absence of alloantibodies, and the presence of Tregs in the accepted kidney. In contrast, recipients of isolated hearts demonstrated acute rejection in 48, 147, and 152 days.

(CONCLUSION)

Tolerance of MHC-mismatched hearts has been achieved in NHPs through kidney co-transplantation and the delayed induction of mixed hematopoietic chimerism. Delaying mixed chimerism conditioning until four months after heart and kidney co-transplantation permits this protocol to be applied to recipients of cadaveric heart and kidney allografts.

CITATION INFORMATION: Tonsho M, Benichou G, Yu R, Boskovic S, Colvin R, Farkash E, Smith R.-N, Allan J, Cosimi A, Kawai T, Madsen J. Delayed Induction of Mixed Chimerism Permits Kidney-Induced Cardiac Allograft Tolerance to be Applied to Recipients of Cadaveric Organs. Am J Transplant. 2016;16 (suppl 3).

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Tonsho M, Benichou G, Yu R, Boskovic S, Colvin R, Farkash E, Smith R-N, Allan J, Cosimi A, Kawai T, Madsen J. Delayed Induction of Mixed Chimerism Permits Kidney-Induced Cardiac Allograft Tolerance to be Applied to Recipients of Cadaveric Organs. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/delayed-induction-of-mixed-chimerism-permits-kidney-induced-cardiac-allograft-tolerance-to-be-applied-to-recipients-of-cadaveric-organs/. Accessed January 25, 2021.

« Back to 2016 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Live Related Kidney Transplant Experience in Abuja, Nigeria – First Eight Cases Ever.
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.