ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Allorecognition"

  • 2022 American Transplant Congress

    Donor-Specific Hyporesponsiveness Following Kidney Transplantation is Explained by Progressive Loss of Donor-Reactive Polyfunctional Cd4+ Effector Memory T Cells

    A. C. van der List, N. H. Litjens, M. Klepper, F. Prevoo, M. G. Betjes

    Internal Medicine, Erasmus MC, Rotterdam, Netherlands

    *Purpose: After kidney transplantation, donor-specific hyporesponsiveness (DSH) develops which is defined as a lowered response of alloreactive T cells to donor antigen while retaining response…
  • 2022 American Transplant Congress

    Establishment of an In Vitro Assay to Evaluate Indirect T-cell Allo-Response Using Donor PBMC-Pulsed Dendritic Cells

    K. Iwasaki1, T. Tomosugi2, T. Sekiya3, H. Hamana4, Y. Miwa1, K. Futamura2, M. Okada2, T. Hiramitsu2, N. Goto2, S. Narumi2, Y. Watarai2, H. Kishi4, M. Okumura5, S. Ashimine5, K. Ishiyama5, T. Kobayashi5

    1Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Japan, 2Department of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, 3Department of Immune Regulation, The Research Center for Hepatitis and Immunology, Ichikawa, Japan, 4Department of Immunology, University of Toyama, Toyama, Japan, 5Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan

    *Purpose: Conventional MLR-based methods which evaluate donor-specific immune response via direct T-cell recognition pathway have been reported to be useful in predicting acute TCMR. However,…
  • 2022 American Transplant Congress

    Identification of Highly-Effective Donor-Reactive CD4+CD8αlo T Cells in CTLA4Ig-Treated Renal Allograft Recipient Monkeys

    M. Kubo, K. Sasaki, L. Lu, V. Vujevich, A. Thomson, M. Ezzelarab

    Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Potent CD4+CD8αlo effector T cells have been reported in transplant (tx) patients. . We evaluated the incidence and function of CD4+CD8αloT cells in renal…
  • 2022 American Transplant Congress

    Are Changes in Clinical Practice Reflected in Gene Expression Profiling Scores After Heart Transplantation?

    T. Wolf-Doty1, K. K. Khush2, J. J. Teuteberg2

    1CareDx, Brisbane, CA, 2Stanford University, Stanford, CA

    *Purpose: AlloMap (AM) is a peripheral blood gene expression profiling (GEP) tool used for the assessment of acute cellular rejection in heart transplant recipients (HT).…
  • 2022 American Transplant Congress

    Toll-Like Receptor-4 Inhibitor, Resatorvid, Attenuates Allogenic T Cell Activation Against Human Pancreatic Islets by Decreasing CD69 Expression

    J. Mattke1, M. Plunk1, R. R. Kane1, B. Naziruddin2

    1Baylor University, Waco, TX, 2Baylor University Medical Ctr, Dallas, TX

    *Purpose: Allogenic and autoimmune response against islets remain major obstacles to improve long term function of islet transplants. Inhibition of toll-like receptor 4 (TLR4) using…
  • 2022 American Transplant Congress

    Binding Mechanisms For Donor Dc-derived Exosomes To Cross-dress Of Recipient Dc

    L. ZHANG1, X. LI1, J. LIU1, H. WEI1, C. LI1, A. HUANG2, C. ZHENG1, Q. LIU1

    1Department of Biochemistry, Southern University of Science and Technology, Shenzhen, China, 2Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

    *Purpose: Our previous evidence suggests donor dendritic cell (DC)-derived exosomes cross-dress recipient DC after heart transplantation in mice. This process plays a critical role in…
  • 2022 American Transplant Congress

    Understanding the Heterogeneity of Alloreactive Natural Killer (NK) Cell Function in Kidney Transplant Recipients

    D. Ruan, M. Fribourg, N. Chun, P. Cravedi, A. Horowitz, P. Heeger

    Icahn School of Medicine at Mount Sinai, New York, NY

    *Purpose: Emerging evidence indicates that human NK cells are a heterogeneous population of lymphocytes that are activated upon ligation of one or more activating receptors…
  • 2022 American Transplant Congress

    Alloimmune Recognition Blocks Recipient Macrophage Differentiation into Reparative Subsets

    J. Warunek1, A. Lucas2, L. R. Mathews2, M. Oberbarnscheidt2, F. Lakkis2, H. Turnquist2

    1Immunology, Thomas E. Starzl Transplantation Institute, University at Pittsburgh, Pittsburgh, PA, 2Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA

    *Purpose: Monocytes differentiate into macrophage subsets that orchestrate tissue repair in response to damage signals and local cytokines. After heart transplant (Tx), graft IL-33 acts…
  • 2022 American Transplant Congress

    Contributions of Allogenicity and Antigen Presentation to Regulatory B Cell Suppression

    K. Lee, F. Qiang, K. Deng, R. Matheson, J. Lei, C. LeGuern, J. Markmann

    Center for Transplantation Sciences, Boston, MA

    *Purpose: We previously generated in vitro Toll-like receptor (TLR)-activated B cells became regulatory B cells (Bregs) that suppress T cell proliferation and promote allograft tolerance.…
  • 2022 American Transplant Congress

    NK Cells in Kidney Allograft Antibody-mediated Rejection Display Increased Proliferation, IL-21 Responsiveness, Type-1 Activation, and Cytotoxic Profile

    E. Bailly1, C. Macedo1, K. Louis2, X. Gu1, B. Ramaswami1, M. Lucas1, C. Bentlejewski1, A. Zeevi1, P. Randhawa1, C. Lefaucheur2, D. Metes1

    1Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, 2INSERM UMR-S976. Endothelium, Inflammation & Alloreactivity, Paris, France

    *Purpose: The role of NK cell during antibody-mediated rejection (ABMR) has been previously recognized, but an in-depth characterization of pathways that contribute to such immune…
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