2020 American Transplant Congress
A Bioinformatics Pipeline for the Identification of Crucial Factors for Transplant Rejection Based on NGS Data
*Purpose: T and B cells are crucial parts of the human immune system and play an important role in transplantation. Since the mechanisms leading to…2020 American Transplant Congress
CD56DimCD16Bright NK Cells from Kidney Transplant Recipients with Antibody-Mediated Rejection Display Increased Proliferation, Self-Renewal, Pro-Inflammatory and Cytotoxic Profile
*Purpose: Contribution of NK cells to antibody-mediated rejection (ABMR) injuries have recently been highlighted through transcriptomic analysis and immunohistochemistry of kidney and heart allograft biopsies.…2020 American Transplant Congress
T Cells from Highly Sensitized Kidney Transplant Patients Display Distinct TCR Repertoires
1RIMUHC, Montreal, QC, Canada, 2McGill University, Montreal, QC, Canada
*Purpose: Sensitization to HLA antigens limits patient’s access to renal transplantation and causes higher risk of acute rejection and graft loss. T-cells, B-cells and donor-specific…2020 American Transplant Congress
The Addition of Splenectomy to Simultaneous Liver Kidney Transplantation Improves Class II DSA Clearance in Sensitized Patients
Department of Transplantation, University of Wisconsin, Madison, WI
*Purpose: The liver allograft clears class I donor specific antibody (DSA) more effectively than class II DSA. Persistent class II DSA in simultaneous liver kidney…2020 American Transplant Congress
Evaluating Preformed Donor HLA Reactive T Cells Using PIRCHE-II Algorithm
*Purpose: De novo donor-specific HLA antibodies (dnDSA) production involves the indirect allorecognition pathway in which recipient CD4+T cells recognize donor-HLA-derived peptide and recipient HLA class…2020 American Transplant Congress
Stability of Immune Phenotype, Alloreactive, and Antiviral Immunity after Switch to Belatacept-Based Regimen after Kidney Transplantation
David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: This investigator-initiated study examines the impact of belatacept on T cell immune phenotype and function.*Methods: 19 patients with evidence of calcineurin inhibitor (CNI) toxicity…2020 American Transplant Congress
Impact of Kidney Transplant Type and Previous Transplant on Baseline Donor-Derived Cell Free DNA
Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA
*Purpose: Donor derived-cell free DNA (dd-cfDNA) is a biomarker useful in predicting acute rejection in renal allografts. The technology uses next generation sequencing and does…2020 American Transplant Congress
Offspring to Parent Living Donor Liver Transplantation: An Analysis of the A2ALL Database
*Purpose: Recently, there have been concerns regarding inferior graft survival following offspring to parent kidney transplantation due to issues related to alloimmunity during pregnancy. It…2020 American Transplant Congress
Determination of Programmed Cell Death Protein 1 (PD1) by Flow Cytometry, a Possible Follow-Up Tool in Renal Transplantation of High Immune Risk
*Purpose: Introduction: Currently, the follow-up of patients remains to be the serum creatinine level, being highly specific, however, with little sensitivity to determine the occurrence…2020 American Transplant Congress
Role of Innate Allorecognition Pathways in Mouse Kidney and Heart Allograft Rejection
*Purpose: Paired immunoglobulin-like receptors (PIR) and CD47 are molecules expressed on host myeloid cells. They recognize donor polymorphic MHC and signal regulatory protein alpha (SIRPα),…
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