ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2022 American Transplant Congress
    • 2021 American Transplant Congress
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2021 Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Search

Combination of Clinical and Genetic Factors for Delayed Kidney Graft Function Prediction

A. Goncalves-Primo,1,2 E. Campos,1,2 J. Medina-Pestana,2,3 H. Tedesco-Silva,3 M. Gerbase-DeLima.1,2

1Immunogenetics Institute, AFIP, São Paulo, SP, Brazil
2Universidade Federal de São Paulo, São Paulo, SP, Brazil
3Hospital do Rim e Hipertensão- FOR, São Paulo, SP, Brazil.

Meeting: 2015 American Transplant Congress

Abstract number: C256

Keywords: Cadaveric organs, Gene polymorphism, Graft function, Kidney

Session Information

Session Name: Poster Session C: Translational Biomarkers and Immune Monitoring

Session Type: Poster Session

Date: Monday, May 4, 2015

Session Time: 5:30pm-6:30pm

 Presentation Time: 5:30pm-6:30pm

Location: Exhibit Hall E

In this study we sought to determine the risk for delayed graft function (DGF) in kidney transplants (Tx) with deceased donors (DD) through the analysis of clinical and genetic factors of donors and recipients. The analysis included 200 Tx performed in a single center, between 2007 and 2012. DGF was defined as the need for dialysis in the first week after Tx and occurred in 51% (102/200) of the Tx. Donor terminal serum creatinine (Cr) > 1.5 mg/dL was the only clinical variable that remained associated with DGF in a multivariate analysis that included clinical variables of donors (age, extended criteria donor, trauma or not trauma death, terminal serum creatinine, recipient/donor body mass index, cold ischemia time, warm ischemia time) and recipients (age, time on dialysis). The genetic polymorphisms, determined by TaqMan OpenArrayTM Genotyping System® (Life Technologies), were selected from a previous study and included: VEGFA (Vascular Endothelial Growth Factor A) rs2146323 in the donors, being the genotypes AA or AC associated with DGF, and GSTP1 (Glutathione S-Transferase P1) rs1871042 in the recipients, being the genotypes TT or TC associated with DGF. The combination of donor Cr >1.5 mg/dL and VEGFA AA or AC genotypes conferred higher risk for DGF in relation to donors with only one or none of these markers (DGF prevalence: 76% vs 41.8%, p <0.0001, OR 4.5, 95% CI: 2.1 – 9.8). The prevalence of DGF in transplants performed with kidneys from these high risk donors was not affected by the GSTP1 genetic polymorphism of the recipient. On the other hand, in transplants with low risk donors the prevalence of DGF was higher in recipients carrying the high than the low risk GSTP1 genotypes (51% vs 32%, p < 0.03, OR 2.2, 95% CI: 1.1 – 4.6). In conclusion, the combination of terminal donor creatinine and genetic polymorphisms in the VEGFA gene of the donor and in the GSTP1 gene of the recipient is valuable to stratify the risk for DGF in Tx with DD.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

To cite this abstract in AMA style:

Goncalves-Primo A, Campos E, Medina-Pestana J, Tedesco-Silva H, Gerbase-DeLima M. Combination of Clinical and Genetic Factors for Delayed Kidney Graft Function Prediction [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/combination-of-clinical-and-genetic-factors-for-delayed-kidney-graft-function-prediction/. Accessed May 28, 2025.

« Back to 2015 American Transplant Congress

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2025 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy | Terms of Use | Cookie Preferences