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Blood Tfh Cells Exhibit Impaired B Cell Help in Operationally Tolerant Patients.

R. Danger,1 A. Chenouard,1 M. Chesneau,1 S. Castagnet,2 P. Guérif,1 N. Degauque,1 M. Giral,1 S. Brouard.1

1Inserm UMR 1064, Nantes University Hospital, Nantes, France
2HLA Laboratory, Etablissement Français du Sang, Nantes, France

Meeting: 2017 American Transplant Congress

Abstract number: C8

Keywords: Alloantibodies, Kidney transplantation, T helper cells, Tolerance

Session Information

Session Name: Poster Session C: Antibody and B Cell

Session Type: Poster Session

Date: Monday, May 1, 2017

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall D1

Introduction: Operationally tolerant (TOL) patients display a defect of B cell differentiation, with a deficiency in circulating plasma cells secreting antibodies, which could partly contribute to a pro-tolerogenic environment. Recently described, T follicular helper (Tfh) cells have been reported to play a critical role in B cell differentiation. Methods: We analyzed the frequency and the function of blood Tfh in TOL patients and transplant patients with stable graft function under immunosuppression (STA). Results: We observed a lower proportion of blood Tfh in TOL patients, with a decrease of activated and functional transcriptional and phenotypical subsets. Functionally, Tfh cells from TOL patients failed to induce IgG production by B cells in coculture, which is associated with a significant decrease of IL-21 secretion by Tfh cells. This in vitro defect is linked to a low incidence of post graft DSA immunization, suggesting that the lack of blood Tfh in TOL patients may participate to a pro-tolerogenic environment with reduced risk to develop de novoDSA (dnDSA). This was further demonstrated by an increased proportion of blood Tfh cells in stable transplant patients, with post graft dnDSA immunization. Conclusion: These data provide new insights into the mechanisms of operational tolerance with an impaired function of blood Tfh that could lead to reduce the risk to develop dnDSA and suggest a potential predictive role of blood Tfh on the occurrence of dnDSA in transplant recipients.

CITATION INFORMATION: Danger R, Chenouard A, Chesneau M, Castagnet S, Guérif P, Degauque N, Giral M, Brouard S. Blood Tfh Cells Exhibit Impaired B Cell Help in Operationally Tolerant Patients. Am J Transplant. 2017;17 (suppl 3).

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To cite this abstract in AMA style:

Danger R, Chenouard A, Chesneau M, Castagnet S, Guérif P, Degauque N, Giral M, Brouard S. Blood Tfh Cells Exhibit Impaired B Cell Help in Operationally Tolerant Patients. [abstract]. Am J Transplant. 2017; 17 (suppl 3). https://atcmeetingabstracts.com/abstract/blood-tfh-cells-exhibit-impaired-b-cell-help-in-operationally-tolerant-patients/. Accessed May 9, 2025.

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