Date: Sunday, June 12, 2016
Session Name: Poster Session B: Kidney Issue in Liver Transplantation
Session Time: 6:00pm-7:00pm
Presentation Time: 6:00pm-7:00pm
Location: Halls C&D
Background: Available literature supports basiliximab induction for safe delay of CNI initiation and renal recovery; however there is a paucity of evidence for use in patients with MELD scores >20. The purpose of this study is to evaluate the effect of basiliximab induction on renal recovery, rejection, and infection in a liver transplant population with high MELD scores.
Methods: A retrospective chart review of adult liver transplant recipients from 2012-2014 with MELD scores >20 was conducted in patients who received steroids at time of transplant, with or without basiliximab induction. All patients received CNI maintenance immunosuppression. Patients were followed for one year post-transplantation.
Results: 70 patients were stratified into the basiliximab (n=35) and steroid only (n=35) cohorts. Baseline characteristics did not differ among groups with the exception of higher MELD scores in the basiliximab group (34.29 vs. 27.63, p=0.0005).
Basiliximab + Steroids n=35
Steroids Only n=35
Age in Years, mean±SD
Male Gender, n (%)
Ethnicity, n (%)
Pre-op MELD, mean±SD
Tacrolimus Levels, mean±SD
Basiliximab allowed CNI delay for 4.31 ±6.11 days versus 1.67 ±1.65 days in the steroid only group (p=0.0276). A significant change from baseline glomerular filtration rate was observed over 12 months in the basiliximab group (+14.51±3.12 mL/min/1.73 m2, p=0.0003). There was no difference in rejection between groups. An increased trend in bacterial infections requiring hospitalization occurred in the steroid only group by end of follow-up (28.57% vs. 3.45%, p=0.07). Variance in MELD scores did not affect graft or patient survival, both of which showed no difference between treatment groups.
Conclusion: Basiliximab induction in high MELD liver transplant recipients permits safe delay of CNI initiation and potential recovery of renal function.
CITATION INFORMATION: Clark J, Sparkes T, Masters B, LaMattina J, Barth R, Moss M. Basiliximab Induction for Safe Delay of Calcineurin Inhibitors in High MELD Liver Transplant Recipients. Am J Transplant. 2016;16 (suppl 3).
To cite this abstract in AMA style:Clark J, Sparkes T, Masters B, LaMattina J, Barth R, Moss M. Basiliximab Induction for Safe Delay of Calcineurin Inhibitors in High MELD Liver Transplant Recipients. [abstract]. Am J Transplant. 2016; 16 (suppl 3). https://atcmeetingabstracts.com/abstract/basiliximab-induction-for-safe-delay-of-calcineurin-inhibitors-in-high-meld-liver-transplant-recipients/. Accessed July 3, 2020.
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