ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "IgG"

  • 2020 American Transplant Congress

    ABH Subtype-Specific Tolerance after ABO-Mismatched Hematopoietic Cell Transplantation

    B. Motyka1, A. Halpin1, J. Pearcey1, A. Kariminia2, A. Halevy2, S. Maier1, A. Halevy2, P. Subrt2, C. W. Cairo1, G. D. Cuvelier3, K. R. Schultz2, L. J. West1

    1Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada, 2British Columbia Children’s Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada, 3CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada

    *Purpose: ABO-mediated immunity is reported to have minimal detrimental impact after ABO-mismatched hematopoietic cell transplantation (HCT). Patients are generally presumed ‘tolerant’ with regard to ABO.…
  • 2020 American Transplant Congress

    Risk Factors for Losing Varicella Immunity after Pediatric Kidney Transplantation

    H. Pizzo1, J. Mirocha2, J. Garrison1, P. R. Soni3, S. Nadipuram3, D. Puliyanda1

    1Pediatric Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA, 2Biostatistics Core, Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, 3Pediatric Infectious Disease, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Vaccination against varicella zoster (VZV) pre-kidney transplant (kid tx) can help prevent severe disseminated VZV disease in immunosuppressed patients (pts) post-tx. Despite confirmation of…
  • 2020 American Transplant Congress

    Outcomes of a Pre-Transplant Desensitization Protocol with Carfilzomib, Plasmapheresis, and IVIG for Broadly Sensitized Lung Transplant Candidates: A Case Series

    S. Fredrick1, C. Iasella2, C. Moore1, M. Mangiola3, Q. Xu3, C. Ensor4, D. Riciutti2, C. LaFratte2, P. Sanchez3, M. Morrell3, J. McDyer3, A. Zeevi3

    1Department of Pharmacy, UPMC Presbyterian, Pittsburgh, PA, 2University of Pittsburgh School of Pharmacy, Pittsburgh, PA, 3University of Pittsburgh School of Medicine, Pittsburgh, PA, 4Department of Pharmacy, AdventHealth, Orlando, FL

    *Purpose: The presence of anti-human leukocyte antigen (HLA) antibodies in lung transplant candidates leads to increased wait list times and antibody-mediated rejection (AMR) post-transplant. We…
  • 2020 American Transplant Congress

    Marginal Zone B Cells Support Donor-Specific Alloantibody Responses to Heart Allografts

    V. Gorbacheva, R. Fan, W. Baldwin, R. Fairchild, A. Valujskikh

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Production of high affinity isotype-switched donor specific alloantibodies (DSA) after transplantation is associated with germinal center formation by follicular (FO) B cells whereas the…
  • 2019 American Transplant Congress

    Clazakizumab (CLZ, Anti-IL-6 Monoclonal Antibody) Treatment of Patients (Pts) with Chronic Antibody-Mediated Rejection (cABMR) Reduces Total Immunoglobulin (Ig) and Anti-HLA IgG Antibody Levels

    B. Shin, N. F. Ammerman, A. A. Vo, X. Zhang, S. C. Jordan, M. Toyoda

    Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: We have recently reported successful use of Tocilizumab (TCZ), an anti-IL-6 receptor (R) monoclonal antibody, for cABMR treatment in HLA-sensitized kidney transplant (KTx) Pts.…
  • 2019 American Transplant Congress

    Individualized Preconditioning for ABO-Incompatible Living Donor Kidney Transplantation: An Initial Report of 48 Cases from China

    X. -. Wang

    Department of Urology/Institute of Urology, West China Hospital of Sichuan University, Chengdu, China

    *Purpose: Typically, the majority of centres that perform ABO incompatible (ABOi) kidney transplantation use fixed preconditioning protocols regardless of the initial titer. As experience in…
  • 2019 American Transplant Congress

    Liver Transplantation in Children with Type 1 and Type 2 Autoimmune Hepatitis

    I. G. Roepe, J. A. Goss, T. Miloh

    Department of Student Affairs, Baylor College of Medicine, Houston, TX

    *Purpose: Autoimmune Hepatitis (AIH) can be defined as type 1 and type 2 based on autoantibodies. Liver transplant (LT) may be indicated for chronic liver…
  • 2019 American Transplant Congress

    QA of MMR/VZV Protocol-Driven Serologic Screening and Infectious Disease Consultation (IDC) Are Strongly Recommended in Heart, Lung, Liver (HLL) SOTs

    Z. Seckin, L. Brumble, C. Libertin

    Mayo Clinic, Jacksonville, FL

    *Purpose: SOT recipients are at risk of acquiring life-threatening infections putting their graft and life at risk. Prevention, including immunization with live virus vaccines pre-transplantation…
  • 2019 American Transplant Congress

    Variable Glycosylations of Anti-HLA Antibodies Detected with Single Antigen Beads in Kidney Transplant Recipients

    Y. Chang1, N. Lemp2, J. Cicciarelli1, T. Shah3, D. Min4

    1Mendez National Institute of Transplantation Foundation, Los Angeles, CA, 2Transplantation Research, Mendez National Institute of Transplantation Foundation, Los Angeles, CA, 3St. Vincent Medical Center, Los Angeles, CA, 4Western Univ of Health Sciences, Pomona, CA

    *Purpose: Differential glycosylation of Immunoglobulin G (IgG) is known to affect its effector functions by modulating interactions with its binding partners, such as C1q or…
  • 2019 American Transplant Congress

    Anti-Donor M H C Class I I Alloantibody Induce Glomerular Injury in Mouse Renal Allografts Subjected to Prolonged Cold Ischemia

    V. Gorbacheva, R. Fan, A. Beavers, R. Fairchild, W. Baldwin, A. Valujskikh

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Prolonged cold ischemia storage (CIS) of donor transplants is a major risk factor for acute and chronic graft tissue injury.The goal of this study…
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