2018 American Transplant Congress
Class II Anti-HLA IgG2 and IgG3 DSAs Predict Poorer Outcomes in Chronic Antibody Mediated Rejection of Renal Allografts
Introduction: whilst the development of IgG3 and C1q binding de novo [dn] HLA DSAs are associated with a poor outcome in acute antibody mediated rejection,…2018 American Transplant Congress
Identification of T Cells as Target of Intervention to Decrease Anti-LG3 Autoantibody Levels Prior to Transplantation
Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada.
Autoantibodies against perlecan/LG3 fragment (anti-LG3) have been associated with accelerated allograft rejection and long-term renal allograft dysfunction. Intriguingly, anti-LG3 are present prior to transplantation in…2018 American Transplant Congress
Two Trajectories of Post-DSA eGFR after Kidney Transplant
A clearer understanding of the patterns of glomerular filtration rate (GFR) decline following donor-specific antibody (DSA) development and the factors that might be associated with…2018 American Transplant Congress
Follow Up of Patients Treated with the IgG Endopeptidase (IdeS) for Desensitization and HLA Incompatible (HLAi) Kidney Transplantation
Introduction:Donor-specific antibodies (DSAs) create an immunologic barrier to transplantation. This prevents transplantation for a significant percentage of highly-HLA sensitized patients (HS). Current desensitization therapies are…2018 American Transplant Congress
Role of Calcium/Calmodulin Kinase IV on Podocyte Function in Transplant Glomerulopathy
Beth Israel Deaconess Medical Center, Boston.
Background : Transplant glomerulopathy(TG) a histological manifestation of chronic antibody mediated rejection and a major cause of late allograft loss. It is well accepted that…2018 American Transplant Congress
IgG De Novo HLA Antibody Subclass Analysis in Patients Undergoing Allograft Nephrectomy after Transplant Failure
Introduction: different immunising events can stimulate the production of disparate antibody subclass profiles, reflecting a diverse extent of T-cell activation. Transplant nephrectomy (NX) is a…2018 American Transplant Congress
Multi-Targeting Desensitization Therapy Alters Peripheral B-Cell Homeostasis and Suppresses Recall Alloantibody Responses
CTC/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Purpose: Occurring of donor specific antibodies (DSA) is injurious to organ transplant. Development of immunotherapies to suppress DSA, therefore, has been one of the strategic…2018 American Transplant Congress
Long Term Culture of Functional Bone Marrow-Derived Human Plasma Cells
Introduction Antibody-secreting plasma cells (PCs) are critically important for host defense, but also can cause antibody-mediated allograft rejection. The ability to study these cells is…2017 American Transplant Congress
Is There Any Difference Between ABO-Incompatible and ABO-Compatible Liver Transplantation? Oncologic Aspect.
Introduction: Liver transplantation (LT) is increasing treatment option for hepatocellular carcinoma (HCC) in East Asia. Over-immunosuppression is risk factor for oncologic outcome after transplantation and…2017 American Transplant Congress
IgG Antibody Subclasses in Potential Renal Transplant Recipients with DSA, AHG-CDC CxM Negative and FxM Positive or Negative with Their Potential Donors.
Background. In kidney transplant recipients, IgG3 and IgG4 DSA have been associated with shorter time to acute AMR and with later allograft injury (glomerulopathy &…
American Transplant Congress abstracts