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α-1 Antitrypsin Facilitate Apoptosis Donor Cells Inducing Donor Specific Protection to Mice Cardiac Allografts

G. Chen, X. Lai, L. Qiu, Y. Zhao, S. Yu, C. Wang, J. Zhang, F. Ning, L. Chen.

Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

Meeting: 2018 American Transplant Congress

Abstract number: A429

Keywords: Apoptosis, Heart/lung transplantation, Mice, Tolerance

Session Information

Session Name: Poster Session A: Tolerance / Immune Deviation

Session Type: Poster Session

Date: Saturday, June 2, 2018

Session Time: 5:30pm-7:30pm

 Presentation Time: 5:30pm-7:30pm

Location: Hall 4EF

Previous study has shown that intravenous infusion of ethylene carbodiimide fixed donor splenocytes(ECDI-SPs) can induce tolerance of mice cardiac allografts with rapidly apoptosis of ECDI-SPs in the spleen of recipients. However, pro-inflammatory cytokine production during the peritransplantation period may negate the effect of ECDI-SPs. Therefore, we hypothesized that blocking pro-inflammatory cytokine secretion while increasing levels of anti-inflammatory cytokines would enhance the tolerance-induced efficacy of ECDI-SPs. The objective of this study was to investigate the efficacy of using ECDI-SPs combined with a short course of α1-antitrysin (AAT) for induction of tolerance. Using a mice cardiac transplant model, we demonstrated that ECDI-SPs plus AAT effectively induced indefinite mice cardiac allograft protection in a donor-specific fashion. This effect was accompanied by modulation of cytokines through decreasing levels of pro-inflammatory cytokines (including IFN-γ, TNF-α, IL-1β, IL-6, IL-17 and IL-23) and increasing levels of anti-inflammatory cytokines (including IL-10, IL-13 and TGF-β),and by inhibition of effector T cells (Teff) and expansion of regulatory T cells (Tregs).In conclusion, AAT appeared to modulate the expression of cytokines to create a support milieu to facilitate ECDI-SP inducing donor specific protection for mice cardiac allografts.

CITATION INFORMATION: Chen G., Lai X., Qiu L., Zhao Y., Yu S., Wang C., Zhang J., Ning F., Chen L. α-1 Antitrypsin Facilitate Apoptosis Donor Cells Inducing Donor Specific Protection to Mice Cardiac Allografts Am J Transplant. 2017;17 (suppl 3).

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To cite this abstract in AMA style:

Chen G, Lai X, Qiu L, Zhao Y, Yu S, Wang C, Zhang J, Ning F, Chen L. α-1 Antitrypsin Facilitate Apoptosis Donor Cells Inducing Donor Specific Protection to Mice Cardiac Allografts [abstract]. https://atcmeetingabstracts.com/abstract/1-antitrypsin-facilitate-apoptosis-donor-cells-inducing-donor-specific-protection-to-mice-cardiac-allografts/. Accessed June 1, 2025.

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