The Importance of Caveolin-1 Immunohistochemical Staining for BK Nephropathy Seen after Kidney Transplantation

E. Arpali¹, E. Sunnetcioglu², Y. Özlük², A. Turkmen³, F. S. Oğuz¹

¹Medical Biology, Istanbul University School of Medicine, Istanbul, Turkey, ²Pathology, Istanbul University School of Medicine, Istanbul, Turkey, ³Nephrology, Istanbul University School of Medicine, Istanbul, Turkey

Meeting: 2020 American Transplant Congress

Abstract number: B-201

Keywords: Kidney transplantation, Nephropathy, Polyma virus

Session Information

Session Name: Poster Session B: Kidney: Polyoma

Session Type: Poster Session

Date: Saturday, May 30, 2020

Session Time: 3:15pm-4:00pm

Presentation Time: 3:30pm-4:00pm

Location: Virtual

*Purpose: To understand the importance of molecular expression of Caveolin-1 in BKV nephropathy seen after kidney transplantion.

*Methods: The kidney transplant patients who had a graft biopsy due to BK virus viremia were divided into two groups according to the BK virus nephropathy found in kidney biopsies (Group I: Viremia +, Nephropathy + / Group II: Viremia+,Nephropathy-). Immunohistochemical staining of the biopsy specimens with anti-caveolin-1 immunoglobulin were performed and compared between the two groups.

*Results: Immunohistochemical staining of the 31 specimens with anti-caveolin-1 immunoglobulin revealed statistically significant difference between group-I and group-II (Table-1)(Figure-1) . The number of the specimens stained with anti-caveolin-1 was less in group I (p=0.0024)

*Conclusions: Variations in the expression paterns of Caveolin-1 molecule may have a protective effect in the kidney transplant patients with BK virus viremia.

Immunohistochemical Staining with Anti-caveolin-1Antibody for the Group I and Group II
	Anti-Caveolin-1 positive	Anti-Caveolin-1 negative	Total
Group I	2	10	12
Group II	15	4	19
Total	17	14	31

To cite this abstract in AMA style:

Arpali E, Sunnetcioglu E, Özlük Y, Turkmen A, Oğuz FS. The Importance of Caveolin-1 Immunohistochemical Staining for BK Nephropathy Seen after Kidney Transplantation [abstract]. Am J Transplant. 2020; 20 (suppl 3). https://atcmeetingabstracts.com/abstract/the-importance-of-caveolin-1-immunohistochemical-staining-for-bk-nephropathy-seen-after-kidney-transplantation/. Accessed November 22, 2024.

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