Contrast-Enhanced Ultrasonography Predicts Insulin Secretion Ability at 1 Year after Pancreas Transplantation

N. Aida¹, T. Kenmochi¹, T. Ito¹, K. Kurihara¹, A. Kawai¹, T. Nishikawa², I. Hiratsuka³, M. Shibata³, A. Suzuki³, M. Hasegawa⁴, M. Kusaka⁵, M. Hoshinaga⁵

¹Transplantation and Regenerative Medicine, Fujita Health University, Toyoake, Japan, ²Liver, Biliary Tract and Pancreas Diseases, Fujita Health University, Toyoake, Japan, ³Endocrinology and Metabolism, Fujita Health University, Toyoake, Japan, ⁴Nephrology, Fujita Health University, Toyoake, Japan, ⁵Urology, Fujita Health University, Toyoake, Japan

Meeting: 2019 American Transplant Congress

Abstract number: D273

Keywords: Graft function, Image analysis, Pancreas transplantation, Ultrasonography

Session Information

Session Name: Poster Session D: Pancreas and Islet: All Topics

Session Type: Poster Session

Date: Tuesday, June 4, 2019

Session Time: 6:00pm-7:00pm

Presentation Time: 6:00pm-7:00pm

Location: Hall C & D

*Purpose: We have previously reported that contrast enhanced ultrasonography (CEUS) is useful to evaluate the graft circulation and to predict the endocrine function of the pancreas graft (Pancreas 2018;47(5):617-624.). In that study, we demonstrated that the time between the time to peak intensity in the parenchyma and that in the vein (delta-Tp(P-V)) reflected the graft perfusion. Delta-Tp(P-V) within 24 hours after transplantation (delta-Tp(P-V)_24h) showed a significant correlation with an insulin secretion at early period after transplantation (Tx). In the present study, we examined the relationship between the graft circulation and the graft function at 1 month and 1 year after Tx.

*Methods: We performed CEUS in 26 patients within 24 hours after pancreas transplantation and calculated delta-Tp(P-V)_24h. Graft function was evaluated with a glucagon stimulation test at 1 month and 1 year after Tx. We examined the relationship between delta-Tp(P-V)_24h and the graft function.

*Results: Median delta-Tp(P-V)_24h was 4.47 (3.15-6.0) seconds. From the results of previous study, we divided the patients into the two groups, based on the levels of delta-Tp(P-V)_24h: the standard group (≤6.10 s) and the delayed group (>6.10 s). The standard group included 20 patients, and the delayed group included 6 patients. The patients in the standard group showed a significantly higher C-peptide increment (delta-CPR) in the glucagon stimulation test both at 1 month after Tx (3.07(2.61-3.61) vs 1.15 (1.06-1.23), p<0.01) and at 1 year after Tx (3.52(2.72-4.38) vs 1.65 (0.91-2.25), p<0.05). In the standard group, delta-CPR at 1 year after Tx significantly increased as compared to those at 1 month after Tx. In contrast, no increase of delta-CPR was observed at 1 year after Tx as compared to those at 1 month after Tx in the delayed group.

*Conclusions: These results demonstrated that pancreatic graft perfusion within 24 h influenced long-term insulin secretion after pancreas transplantation. CEUS is useful for the prediction of the endocrine function after pancreas transplantation.

To cite this abstract in AMA style:

Aida N, Kenmochi T, Ito T, Kurihara K, Kawai A, Nishikawa T, Hiratsuka I, Shibata M, Suzuki A, Hasegawa M, Kusaka M, Hoshinaga M. Contrast-Enhanced Ultrasonography Predicts Insulin Secretion Ability at 1 Year after Pancreas Transplantation [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/contrast-enhanced-ultrasonography-predicts-insulin-secretion-ability-at-1-year-after-pancreas-transplantation/. Accessed May 18, 2025.

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