The Predictive Value Of Pre-transplant Biopsies For Short-term And Long-term Graft Function In Kidney Transplantation

H. Zhang¹, L. Liu¹, S. Yang², W. Chen², X. Chen¹, Y. Li², C. Wang¹

¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

Meeting: 2019 American Transplant Congress

Abstract number: B152

Keywords: Donation, Graft function, Graft survival

Session Information

Session Name: Poster Session B: Kidney Donor Selection / Management Issues

Session Type: Poster Session

Date: Sunday, June 2, 2019

Session Time: 6:00pm-7:00pm

Presentation Time: 6:00pm-7:00pm

Location: Hall C & D

*Purpose: The predictive capacity of previous pre-transplant histologic scoring systems for short-term and long-term graft function in kidney transplantation has not been adequately validated.

*Methods: Deceased donor kidney recipients transplanted in a single center between 2014 and 2018 who underwent a pre-transplant donor kidney allograft biopsy were included in this study (N=181). The formalin-fixed paraffin-embedded biopsies were rescored according to the existing 8 scoring systems (Remuzzi, Pirani, MAPI, Total Chronic Banff Score, CADI, Banff donor score, DDS, Ugarte score).

*Results: The average age of recipients and donors were 43±14 and 34±14 years old. The follow-up time was 1.12 year on average. All scoring systems presented a trend that biopsies with high score increased the risk of DGF and death-censored graft survival and reduced 1-year eGFR. Ugarte and Banff donor scoring system had a good predictive capacity for DGF.

*Conclusions: Both Ugarte and Banff donor scoring system had a good predictive capacity for short-term graft function in kidney transplantation. It could be explained by the inclusion of acute tubular injury as their assessment component.

Table 1. Biopsy score and graft function
Scorin g system	DGF (OR)	Death-censored graft survival (HR)	1-year eGFR (ml/min*1.73m²)
Remuzzi(severe & moderate vs mild)	2.217	3.778	-7.677
MAPI(severe & moderate vs mild)	1.524	–	-12.506
DDS(severe & moderate vs mild)	1.458	3.394	-8.099
Ugarte score(severe & mild vs no)	3.835*	2.095	-9.523
Total Chronic Banff Score(severe & moderate vs mild)	1.636	1.431	-8.738
CADI(severe & moderate vs mild)	1.425	1.274	-8.738
Banff Donor Score(severe & moderate vs mild)	2.122*	1.737	-7.656

To cite this abstract in AMA style:

Zhang H, Liu L, Yang S, Chen W, Chen X, Li Y, Wang C. The Predictive Value Of Pre-transplant Biopsies For Short-term And Long-term Graft Function In Kidney Transplantation [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/the-predictive-value-of-pre-transplant-biopsies-for-short-term-and-long-term-graft-function-in-kidney-transplantation/. Accessed November 22, 2024.

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