Acute kidney injury(AKI)after liver transplantation (LT) is common.Calcineurin inhibitors(CNI)have to be well-balanced.The aims were analyze the specific effect of CNI on AKI in a cohort of patients and to analyze the profile of AKI-RIFLE categories in the post-LT setting and its impact on post-transplant-survival.A retrospective analysis of 400 patients transplanted at Reina Sofia and King's College Hospital was performed.Exclusion criteria were paediatric transplants,death<14 days and CNI-free regimes.Endpoints were: Development of AKI and 1-year survival.Incidence of AKI-Risk-Injury-Failure in the first 2 weeks after LT was 59,8, 34,3 and 8,4%.The development of any AKI had no impact on overall 1-year survival.In multivariate analysis,transfusions(OR=1,15[1,04-1,3]),peak-postLT-transaminases(OR=2,9[1,01-8,77],pretransplant eGFR(OR=10,54[1,88-59,1])and normal-CNI-dose strategies(OR=0,29[0,14-0,61])were independent predictors of AKI_Risk.Peak post-LT-transaminases(OR=3,3[1,39-7,8])and normal-CNI-dose strategies(OR=0,31[0,15-0,62])were predictors of AKI_Injury.Only peak post-LT-transaminases(OR=6,8[2,6-16,8])was a predictor of AKI_Failure.In the general linear models,strategies with low-CNI doses were only useful to prevent severe impairment in patients with extremely-low pre-transplant eGFR.AKI is frequent after LT.Transfusion, immediate liver function, pretx status and IS are factors that predict mild AKI.However,only immediate liver function predicts severe AKI.AKI happens similarly in all pre-tx eGFR status groups.Low CNI regimes are mildly useful in severely impaired eGFR pretx status patients being useless when pretransplant normal kidney function is preserved

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