Organ damage associated with processes occurring during the ischaemic period as well as during and after organ reperfusion is an important problem of transplantation medicine.

The aim of the study was to evaluate the effect of the treatment with a TNF-alpha inhibitor in hypothermic machine perfusion (HMP) on the function of the allogenic kidney transplant.

The study included 100 kidneys harvested for transplantation from deceased donors. Before transplantation all kidneys were stored with use of HMP. Kidneys from each pair were randomly, alternately assigned to one of two groups: study group (A) with a TNF-alpha inhibitor, etanercept, added to the perfusion fluid after the first hour of perfusion, and control group (B) – with no intervention.

No significant differences with respect to incidence of DGF were found. Analysis of functional DGF (fDGF) and of AR episodes showed a lower number of these events in study group A, as compared to control group B: 21.3% vs. 31.9% and 10.6% vs 19.1%, respectively. However statistical significance was not reached. Creatinine concentration (mg/dL) after 12 months from transplantation was 1.61 vs. 1.51, and after 24 months – 1.43 vs. 1.34 in groups A vs. B, respectively (p=NS).

Comparison of the above results did not show any differences of transplanted kidney function related to the study intervention. This is the first prospective clinical study in the world evaluating the treatment of an isolated organ with a TNF-alpha inhibitor during HMP of a human kidney.

CITATION INFORMATION: Diuwe P, Domagala P, Kieszek R, Wszola M, Serwanska-Swietek M, Paczek L, Durlik M, Chmura A, Kwiatkowski A. The Effect of the Use of a TNF-Alpha Inhibitor in Hypothermic Machine Perfusion on Kidney Function After Transplantation. Am J Transplant. 2016;16 (suppl 3).

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