2022 American Transplant Congress
A Signature of Tolerance Which Identifies Subclinical Rejection-Free Patients at One Year After Kidney Transplantation
*Purpose: Spontaneous and rare cases of patients undergoing a functional renal transplant in the absence of immunosuppression represent a particular situation of immune tolerance. We…2022 American Transplant Congress
Technology-Driven Performance Improvement of a Biomarker Panel in Kidney Transplant: OmniGraf
*Purpose: Analyze the impact of the transition from TruGraf microarray to TruGraf PCR on the complementary performance characteristics of TruGraf plus TRAC (OmniGraf).*Methods: Development of…2022 American Transplant Congress
Establishment And Validation Of A Predictive Model For Differential Rejection Diagnosis By Gene Expression Profiling (GEP) In Renal Allograft Biopsies Using Banff Human Organ Transplant (B-HOT) Gene Panel
1CareDx, Inc., Brisbane, CA, 2Arkana Laboratories, Little Rock, AR
*Purpose: Large scale GEP studies evaluating the performance of Banff-endorsed B-HOT gene panel for allograft rejection diagnosis have not been published. In this study, we…2022 American Transplant Congress
Protein and Transcriptomic Differences Between High and Low Neointimal Arteries in Human Cardiac Allograft Vasculopathy Rejected Grafts
*Purpose: Cardiac allograft vasculopathy (CAV) is the leading cause of graft failure and mortality following heart transplantation. Donor specific antibodies (DSA) contribute to CAV progression…2022 American Transplant Congress
Crosstalk Between micro-RNAs, mRNAs, and Long Non-Coding RNAs in Human Hepatic Ischemia Reperfusion Injury
*Purpose: Present study utilizes multiple omics tools and clinical samples with a system biology approach characterizing mRNAs, long non-coding RNAs (lncRNAs) and small non-coding RNAs…2022 American Transplant Congress
Evaluating Long Term Outcomes in Kidney Transplant Patients with TruGraf Gene Expression and TRAC Dd-cfdna in the TRULO Study
Eurofins Transplant Genomics, Framingham, MA
*Purpose: The aim of this study is to evaluate long term clinical outcomes in kidney transplant patients undergoing non-invasive rejection monitoring with the OmniGraf® biomarker…2022 American Transplant Congress
Single Cell RNA Sequencing Identifies Primarily Terminal Effector and Exhausted CD8+T Cells in Chronically Rejected Human Kidney Allografts
*Purpose: Chronic renal allograft rejection often leads to irreversible damage, despite intensification of immunosuppression (ISN). T cell phenotypes in this clinical setting are not well…2022 American Transplant Congress
Differing Gene Expression Profiles and Signaling Pathways Observed Between Alloreactive and Tolerant T Cells in a Recipient Following Bilateral Orthotopic Lung Transplant (BOLT) and Bone Marrow Transplant (BMT) from the Same Cadaveric UNOS Donor
UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA
*Purpose: Primary immunodeficiency (PID) patients may develop pulmonary complications, and most are ineligible for either BOLT or BMT due to futility. A prospective trial in…2022 American Transplant Congress
Novel Drug Target Identified for Reversal of Renal Tubular Injury
*Purpose: Understanding the unique susceptibility of the human kidney tubule to oxidative cell stress and to identify compounds to support reversal of renal tubular damage.*Methods:…2022 American Transplant Congress
Donor-Derived Cell-Free DNA and Gene Expression Profiling for Surveillance of Renal Allograft Injury and Rejection
University of Maryland, Baltimore, MD
*Purpose: Donor derived cell free DNA (dd-cfDNA) and gene expression profiling offer non-invasive methods of early detection of graft injury and rejection in solid organ…
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