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Articles tagged "Xenotransplantation"

  • 2016 American Transplant Congress

    Eliminating Xenoantigen Expression on Swine Red Blood Cells.

    Z.-Y. Wang,1 G. Martens,1 R. Blankenship,1 R. Sidner,1 P. Li,1 J. Estrada,1 M. Tector,2 A. Tector.1,3

    1Surgery, Indiana University School of Medicine, Indianapolis, IN; 2Surgery, Indiana University Health, Indianapolis, IN; 3Indiana University Health Transplant Institute, Indianapolis, IN.

    Background:The rapidly improving tools of genetic engineering may make it possible to overcome humoral immune barrier that prevents xenotransplantation. We hypothesize that levels of human…
  • 2016 American Transplant Congress

    Impact of Mixed Xenogeneic Porcine Hematopoietic Chimerism on Human NK Cell Recognition in a Humanized Mouse Model.

    H. Li,1 P. Vishwasrao,1,2 M. Holzl,1 S. Chen,1 G. Choi,2,3 G. Zhao,1 M. Sykes.1

    1Columbia Center for Translational Immunology, Columbia University, New York, NY; 2Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands; 3Department of Hematology, University Medical Center Groningen, Groningen, Netherlands.

    Xenotransplantation is a potential solution for the shortage of organs for transplantation. However, potent xenograft rejection responses present a formidable barrier. Mixed xenogeneic hematopoietic chimerism…
  • 2016 American Transplant Congress

    Long Term Heterotopic Cardiac Xenograft Survival from Donor Pigs with Six Gene Modifications.

    M. Mohiuddin,1 A. Singh,1 J. Chan,1 P. Corcoran,1 M. Thomas III,2 B. Lewis,2 D. Ayares,3 K. Horvath.1

    1CSRP, NHLBI/NIH, Bethesda, MD; 2DVR / RS, NIH, Bethesda, MD; 3Revivicor, Inc, Blacksburgh, VA.

    Introduction: We have recently reported pig xenograft survival of more than 2.5 years in a heterotopic cardiac xenograft model. Some of the animals exhibited local…
  • 2016 American Transplant Congress

    Human Leukocyte Antigen-E Expression on Porcine GalTKO.hCD46 Cells Improves Ex-Vivo Xenograft Survival and Attenuates Injury.

    C. Laird,1 N. Kubicki,1 L. Burdorf,1 T. Zhang,1 X. Chang,1 G. Braileanu,1 C. Phelps,2 D. Ayares,2 A. Azimzadeh,1 R. Pierson.1

    1University of Maryland School of Medicine, Baltimore, MD; 2Revivicor, Inc, Blacksburg, VA.

    Purpose:Lung xenografts are subject to injury mechanisms associated with the sequestration of human cells, including natural killer (NK) cells. To control NK cell associated injury,…
  • 2015 American Transplant Congress

    Extended Life-Supporting Xenogeneic Lung Function With Multi-Transgeneic Donor Pigs and Targeted Drug Treatments

    L. Burdorf,1 E. Rybak,1 T. Zhang,1 D. Harris,1 S. Dahi,1 N. Kubicki,1 D. Parsell,1 E. Sievert,1 D. Ayares,2 A. Azimzadeh,1 R. Pierson III.1

    1University of Maryland, Baltimore; 2Revivicor, Blacksburg.

    Purpose: Prolonged life-supporting (LS) xenolung function has proven difficult to accomplish. Here we report results from 21 xLTXs in a rigorous, LS pig-to-baboon model, asking…
  • 2015 American Transplant Congress

    Orthotopic Transplantation of a Tissue Engineered Skin Graft in Athymic Mice

    N. Nayakawde, P. Patil, K. Methe, M. Olausson.

    Surgery, Gothenburg University, Gothenburg, Vastra Gotaland, Sweden.

    Background: Tissue engineered (TE) skin offers promising alternative treatment in wound healing of acute and chronic skin injuries. Limited autografts from donor skin and risks…
  • 2015 American Transplant Congress

    Identifying Barriers Specific to Xenoislets by Direct Comparison to Alloislets in a Dual Transplant Model

    K. Samy,1 B. Martin,2 P. Thompson,2 A. Farris,2 M. Song,2 V. Leopardi,1 B. Collins,1 A. Kirk.1

    1Department of Surgery, Duke University Medical Center, Durham, NC; 2Emory Transplant Center, Emory University, Atlanta, GA.

    Purpose:The xenotransplantation of neonatal porcine islets (NPIs) may alleviate the shortage of islets currently limiting islet allotransplantation. However, successful implementation requires understanding of the immune…
  • 2015 American Transplant Congress

    Detergent-Sonication Method for the Whole Laryngeal Decellularization

    N. Nayakawde,1 K. Methe,1 M. Berg,2 G. Premaratne,1 H. Ejnell,2 M. Olausson.1

    1Surgery, Gothenburg University, Gothenburg, Vastra Gotaland, Sweden; 2Departments of 1Otolaryngology, Head and Neck Surgery, Gothenburg University, Gothenburg, Vastra Gotaland, Sweden.

    Background: Each year, about 136,000 individuals worldwide are diagnosed with larynx carcinoma. Tissue engineered organs shows promising alternative to a conventional transplantation in both preclinical…
  • 2015 American Transplant Congress

    Characteristics of IgGs Produced in Neu5Gc and α1-3 Gal Double Knock-Out Pigs

    A. Salama,1,2 S. Conchon,1 A. Perota,3 B. Martinet,1 J.-P. Judor,1 G. Evanno,1 S. Le-Bas Bernardet,1 L. Le Berre,1 J. Hervouet,1 D. Minault,1 J.-P. Concordet,4 E. Dugast,1 B. Vanhove,1 J. Abadie,5 N. Gaide,5 I. Lagutina,3 R. Duchi,3 G. Lazzari,3 D. Sachs,6 O. Gauthier,7 S. Brouard,1 E. Cozzi,8 G. Blancho,1 H. Perreault,9 J.-M. Bach,10 C. Galli,3,11 J.-P. Soulillou.1

    1INSERM UMR 1064, ITUN, CHU de Nantes, Nantes University, Nantes, France; 2Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France; 3Avantea, Laboratory of Reproductive Technologies, Cremona, Italy; 4INSERM U565, CNRS UMR7196, MNHN USM503, Paris, France; 5AMaROC, ONIRIS, Nantes, France; 6Massachusetts General Hospital, Transplantation Biology Research Center, Boston, MA; 7Centre de Recherche et d'Investigation Préclinique, ONIRIS, Nantes, France; 8Padua General Hospital and Consortium for Research in Organ Transplantation, Padua, Italy; 9Chemistry Department, University of Manitoba, Winnipeg, Canada; 10IECM, EA4644 University/ONIRIS USC1383 INRA, ONIRIS, Nantes, France; 11Dept. of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.

    Xenotransplantation offers a large number of potential applications, including solid organs, pancreatic islets, acellular tissues such as heart valves and skin grafts, and new bioreagents…
  • 2015 American Transplant Congress

    Human Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact

    E. Montanari,1 R. Mahou,1,2 S. Passemard,2 F. Noverraz,2 P. Morel,1 R. Meier,1 D. Bosco,1 J. Seebach,3 C. Wandrey,2 S. Gerber,2 C. Gonelle-Gispert,1 L. Buhler.1

    1Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland; 2Institut d'Ingénierie Biologique et Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 3Division of Immunology and Allergy, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland.

    Background and Aim:The aim of this study was to evaluate the survival and function of human pancreatic islets co-encapsulated with human Mesenchymal Stromal Cells (MSC)…
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