Articles tagged "Xenotransplantation"

2017 American Transplant Congress
CD4 Depletion Is Necessary and Sufficient for Long-Term Nonhuman Primate Xenotransplant Survival.
S. Kim, L. Higginbotham, D. Mathews, C. Breeden, A. Stephenson, C. Larsen, M. Ford, J. Tector, A. Adams.
Emory Transplant Center, Emory University, Atlanta, GA; University of Alabama Birmingham, Birmingham, AL
Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplant has met limited success. We have previously reported the longest surviving pig-to-nonhuman primate (NHP)…
2017 American Transplant Congress
CD4⁺/CD8⁺ T Cell Ratio as a Predictive Marker for Early Graft Failure in Pig to Non-Human Primate Islet Xenotransplantation with Immunosuppression.
S. Choi,^1,3,4 H.-J. Kim,^1,2,3,4 I.-H. Yoon,^1,2 J.-S. Kim,^1,2,6 S.-J. Kang,^1,2,3,4 H.-Y. Nam,^1,2 B.-H. Min,¹ J.-S. Shin,^1,6 J.-M. Kim,^1,6 Y.-H. Kim,^1,5 W.-W. Lee,^1,2,3,4 C.-G. Park.^1,2,3,4,6
¹Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea; ²Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea; ³Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea; ⁴Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea; ⁵Department of Microbiology, Kyungpook National University School of Medicine, Daegu, Korea; ⁶Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Korea
Background: Outstanding results from nonhuman primate study put islet xenotransplantation with immunosuppression closer to the clinical application. To establish successful immune suppressive protocols, immune monitoring…
2017 American Transplant Congress
CD28 Directed Immunotherapy Is More Potent Than Belatacept in a Nonhuman Primate Xenotransplant Model.
S. Kim,¹ L. Higginbotham,¹ D. Mathews,¹ C. Breeden,¹ A. Stephenson,¹ C. Larsen,¹ M. Ford,¹ J. Tector,² A. Adams.¹
¹Emory Transplant Center, Emory University, Atlanta, GA; ²University of Alabama Birmingham, Birmingham, AL
Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplantation has met limited success. T cell-mediated damage remains a critical problem. Our group has…
2017 American Transplant Congress
Depletion of T-Cells from G-CSF Mobilized Human PBMC Prevents Acute GVHD in NSG Mice.
Y. Huang, H. Xu, A. Merchak, A. Chhabra, Y. Wen, L. Kahn, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY
Allogeneic HSC transplantation is commonly utilized for the treatment of hematologic malignancies and autoimmune diseases. However, allogeneic HSC transplantation is limited by potential for the…
2017 American Transplant Congress
The Beneficial Effect of Janus Kinase 3 Inhibitor on Transplanted Islet via Protection from Oxidative Stress-Induced β Cell Death.
S.-J. Kang,^1,2,3,4 H. Chung,^1,2,3,4 S. Lee,^1,2,3,4 J.-S. Shin,^1,3,5 H.-J. Kim,^1,2,3,4 J.-M. Kim,^1,3,5 B.-H. Min,^1,3,5 S. Choi,^1,2,3,4 C.-G. Park.^1,2,3,4,5
¹Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea; ²Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea; ³Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea; ⁴Department of Biomedical Sciences, Seoul National University, Seoul, Korea; ⁵Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Korea
Janus kinase 3 (JAK3) is one of the molecules that make up the JAK-STAT signaling pathway that regulates numerous 40 cytokines. Thus, this cascade can…
2017 American Transplant Congress
Beneficial Effects of Human Mesenchymal Stromal Cells on Porcine Hepatocytes Viability and Albumin Secretion.
E. Montanari,¹ J. Pimenta,¹ H.-J. Schuurman,¹ J. Meier,¹ R. Meyer,¹ A. Balaphas,¹ J. Sidibé,² A. Thomas,² S. Passemard,³ S. Gerber-Lemaire,³ C. Gonelle-Gispert,¹ L. Buhler.¹
¹Department of Surgery, University of Geneva, Geneva, Switzerland; ²University Centre of Legal Medicine, Universities of Lausanne and Geneva, Geneva and Lausanne, Switzerland; ³Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
Aim: Acute liver failure carries a very high mortality and transplantation of encapsulated pig hepatocytes might temporarily compensate the metabolic functions until the dysfunctional liver…
2017 American Transplant Congress
PTEN Inhibition in MSC Upregulates PD-L1 and Enhances Their Immunomodulatory Capacity Prolonging Skin Allograft Survival.
M. Climov, M. Uehara, Z. Solhjou, H. Matsumine, N. Bouyani, E. Kefaloyianni, B. Basmani, V. Kasinath, G. Giatsidis, D. Orgill, R. Abdi.
Brigham and Women's Hospital, Boston, MA
Due to lack of autologous and donor site morbidity, there is a distinct clinical need to increase the utility of skin allografts by improving their…
2017 American Transplant Congress
Human IL-10 Transfection of Porcine Lungs Significantly Increases IL-10 Levels in Vascular Perfusate During Human Blood Perfusion.
C. Laird,¹ L. Burdorf,¹ X. Cheng,¹ N. O'Neill,¹ S. Sendil,¹ D. Parsell,¹ M. Cypel,² C. Phelps,³ D. Ayares,³ A. Azimzadeh,¹ R. Pierson.¹
¹University of Maryland School of Medicine, Baltimore, MD; ²Department of Surgery, Toronto, Canada; ³Revivicor, Inc, Blacksburg, VA
PurposePorcine organs are a potential source for clinical xenotransplantation. Pig lungs perfused with human blood exhibit inflammation and loss of vascular barrier function within hours.…
2017 American Transplant Congress
CXCL12 Modulation of Localized Immune Responses to Subcutaneous Islet Macrocapsulation.
M. Penson, M. Sremac, R. Sirbulescu, T. Brauns, F. Harrington, M. Poznansky.
Infectious Disease, Massachusetts General Hospital, Boston, MA
Purpose:To determine the impact of CXCL12 on vascularization and immune response to xeno islets transplanted into TheraCyte macroencapsulation device in diabetic C57BL/6 mice.Materials and Methods:Three…
2017 American Transplant Congress
D-Dimer Level, in Association with Humoral Responses, Negatively Correlates with Survival of Porcine Islet Grafts in Nonhuman Primates with Immunosuppression.
H. Kang,¹ H. Lee,¹ E. Park,¹ J. Kim,² B. Min,² C.-G. Park.²
¹Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea; ²Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea
Background: Several immunosuppression (IS) regimens achieve long-term graft survival in nonhuman primates (NHPs) after porcine islet transplantation (PITx), but their success rates vary. To understand…