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Articles tagged "Xenotransplantation"

  • 2017 American Transplant Congress

    Prolonged Survival with Co-Stimulatory Blockade Based Immunosuppression in Pig-to-Primate Liver Xenotransplantation.

    J. Shah, M. Patel, N. Elias, I. Rosales, N. Navarro-Alvarez, M. Hertl, A. Cosimi, R. Colvin, J. Markmann, D. Sachs, P. Vagefi.

    Massachusetts General Hospital, Boston, MA

    Background: Since the first attempt in 1968, survival following pig-to-baboon liver xenotransplantation (LXT) has been limited to <9-days due to a lethal coagulopathy. To improve…
  • 2017 American Transplant Congress

    Lack of Xenograft Recipient Monitoring by Telemetry Lets Infection Go Unchecked and Trigger Coagulopathy.

    M. Mohiuddin,1 A. Singh,1 J. Chan,1 P. Corcoran,1 B. Lewis,2 M. Thomas,2 D. Ayares,3 K. Horvath.1

    1NHLBI / NIH, Bethesda; 2ORS / NIH, Bethesda; 3Revivicor, Inc, Blackburgh

    Introduction: A major complication of a xenograft is the potential for coagulation disorder characterized by thrombocytopenia and bleeding. This complication was rarely seen in our…
  • 2017 American Transplant Congress

    Orthotopic Liver Transplantation of Xenogeneic Livers Repopulated with Autologous Hepatocytes: Proof of Normal Function and Consistent Survival.

    G. Oldani, S. Lacotte, L. Orci, V. Delaune, C. Toso.

    Geneva University Hospitals, Geneva, Switzerland

    BackgroundGeneration of transplantable patient-like organs in pigs will solve the problem of organ shortage and potentially extend the indications for liver transplantation. However, the efficacy…
  • 2017 American Transplant Congress

    The Role of Anti-Neu5Gc IgM in Xenograft Antibody Mediated Rejection.

    W. Hassanein,1 G. Braileanu,1 L. Burdorf,1 W. Sun,1 B. French,1 C. Laird,1 S. Sendil,1 C. Ahn,3 D. Ayares,2 R. Pierson III,1 A. Azimzadeh.1

    1University of Maryland School of Medcine, Baltimore, MD; 2Revivicor, Blacksburg, VA; 3Seoul National University Hospital, Seoul, Korea

    Background:Acute antibody mediated rejection due to preformed antibodies present in human serum remains a hurdle to successful xenotransplantation. Here, we measured anti-Neu5Gc-IgM antibody titers in…
  • 2017 American Transplant Congress

    Early Detection of Xenograft Rejection or Injury by Donor Derived Cell Free DNA in Pig to Baboon Cardiac Xenotransplantation.

    A. Singh,1 S. Agbor-Enoh,2 J. Chan,1 S. Groham,2 P. Corcoran,1 B. Lewis,3 M. Thomas,3 D. Ayares,4 K. Horvath,1 H. Valantine,2 M. Mohiuddin.1

    1CSRP, NHLBI/NIH, Bethesda, MD; 2LTG, NHLBI/NIH, Bethesda, MD; 3ORS/NIH, Bethesda, MD; 4Revivicor, Inc, Blacksburg, VA

    Detection of early graft rejection (EGR) is a great deal in the field of transplantation (Tx). A number of biomarkers have been used to determine…
  • 2017 American Transplant Congress

    Thrombalexin and Mirococept Synergistically Reduce IBMIR in a Porcine to Rhesus Xenoislet Model.

    M. Manook,1,2 J. Kwun,1 J. Yoon,1 K. Samy,1 A. MacDonald,1 H. Xu,1 R. Smith,3 A. Dorling,3 A. Kirk,1 N. Mamode,2 S. Knechtle.1

    1Surgery, Duke Transplant Center, Durham, NC; 2Renal and Transplant, Guy's and St Thomas'NHS Foundation Trust, London, United Kingdom; 3MRC Centre for Transplantation, King's College, London, United Kingdom

    Introduction: Early activation of coagulation and complement are important factors in the initiation of instant blood mediated inflammation (IBMIR) in xenoislet models. Two novel 'cytotopic'…
  • 2017 American Transplant Congress

    CD4 Depletion Is Necessary and Sufficient for Long-Term Nonhuman Primate Xenotransplant Survival.

    S. Kim, L. Higginbotham, D. Mathews, C. Breeden, A. Stephenson, C. Larsen, M. Ford, J. Tector, A. Adams.

    Emory Transplant Center, Emory University, Atlanta, GA; University of Alabama Birmingham, Birmingham, AL

    Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplant has met limited success. We have previously reported the longest surviving pig-to-nonhuman primate (NHP)…
  • 2017 American Transplant Congress

    CD4+/CD8+ T Cell Ratio as a Predictive Marker for Early Graft Failure in Pig to Non-Human Primate Islet Xenotransplantation with Immunosuppression.

    S. Choi,1,3,4 H.-J. Kim,1,2,3,4 I.-H. Yoon,1,2 J.-S. Kim,1,2,6 S.-J. Kang,1,2,3,4 H.-Y. Nam,1,2 B.-H. Min,1 J.-S. Shin,1,6 J.-M. Kim,1,6 Y.-H. Kim,1,5 W.-W. Lee,1,2,3,4 C.-G. Park.1,2,3,4,6

    1Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea; 2Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea; 3Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea; 4Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea; 5Department of Microbiology, Kyungpook National University School of Medicine, Daegu, Korea; 6Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Korea

    Background: Outstanding results from nonhuman primate study put islet xenotransplantation with immunosuppression closer to the clinical application. To establish successful immune suppressive protocols, immune monitoring…
  • 2017 American Transplant Congress

    CD28 Directed Immunotherapy Is More Potent Than Belatacept in a Nonhuman Primate Xenotransplant Model.

    S. Kim,1 L. Higginbotham,1 D. Mathews,1 C. Breeden,1 A. Stephenson,1 C. Larsen,1 M. Ford,1 J. Tector,2 A. Adams.1

    1Emory Transplant Center, Emory University, Atlanta, GA; 2University of Alabama Birmingham, Birmingham, AL

    Introduction. Xenotransplantation may alleviate the organ shortage, yet experimental renal xenotransplantation has met limited success. T cell-mediated damage remains a critical problem. Our group has…
  • 2017 American Transplant Congress

    Depletion of T-Cells from G-CSF Mobilized Human PBMC Prevents Acute GVHD in NSG Mice.

    Y. Huang, H. Xu, A. Merchak, A. Chhabra, Y. Wen, L. Kahn, S. Ildstad.

    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY

    Allogeneic HSC transplantation is commonly utilized for the treatment of hematologic malignancies and autoimmune diseases. However, allogeneic HSC transplantation is limited by potential for the…
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