2017 American Transplant Congress
A Swine for Human MHC Class I Swap: Implications for Xenotransplantation.
Background: Xenotransplantation is a potential supply-side solution to the growing need for life-saving transplantable organs, but it was not until the recent advances in genetic…2017 American Transplant Congress
Autologous Expanded Tregs and Porcine Hematopoietic Cells to Prolong Xenogeneic Pig Skin Graft Acceptance in Baboons.
Background: Mixed chimerism (MC) has been shown to induce tolerance to allogeneic organs and has shown promise for application to xenotransplants, although long-term tolerance has…2017 American Transplant Congress
Binding of Human Neutrophils to Activated Porcine Endothelium Is Mediated by E-Selectin.
1University of Maryland SOM, Baltimore; 2GlycoMimetics, Inc, Rockville; 3Revivicor, Inc, Blacksburg
Purpose: Shortage of transplantable human organs motivates research into alternatives, including xenotransplantation. When porcine lungs are perfused with human blood, a majority of human neutrophils…2017 American Transplant Congress
Addition of hEPCR.hCD55.hTFPI.hCD47 Modulates Multi-Lineage Cell Sequestration and Coagulation Activation by GalTKO.hCD46 Transgenic Pig Livers Perfused Ex Vivo with Human Blood.
PurposeThe sequestration of multiple hematopoietic cell lineages and inappropriate coagulation cascade activation is associated with poor outcomes in multiple liver xenotransplant models. Here we evaluate…2017 American Transplant Congress
Coagulation Pathway Perturbations Associated with Pig-to-Baboon Lung Xenotransplantation.
Department of Surgery, University of Maryland, School of Medicine, Baltimore, MD
Aim Dysregulation of coagulation is associated with graft failure in multiple xenotransplantation models. This study describes thromboelastographic profiles in baboon recipients of a genetically engineered…2017 American Transplant Congress
Prolonged Survival with Co-Stimulatory Blockade Based Immunosuppression in Pig-to-Primate Liver Xenotransplantation.
Massachusetts General Hospital, Boston, MA
Background: Since the first attempt in 1968, survival following pig-to-baboon liver xenotransplantation (LXT) has been limited to <9-days due to a lethal coagulopathy. To improve…2017 American Transplant Congress
Lack of Xenograft Recipient Monitoring by Telemetry Lets Infection Go Unchecked and Trigger Coagulopathy.
1NHLBI / NIH, Bethesda; 2ORS / NIH, Bethesda; 3Revivicor, Inc, Blackburgh
Introduction: A major complication of a xenograft is the potential for coagulation disorder characterized by thrombocytopenia and bleeding. This complication was rarely seen in our…2017 American Transplant Congress
Orthotopic Liver Transplantation of Xenogeneic Livers Repopulated with Autologous Hepatocytes: Proof of Normal Function and Consistent Survival.
Geneva University Hospitals, Geneva, Switzerland
BackgroundGeneration of transplantable patient-like organs in pigs will solve the problem of organ shortage and potentially extend the indications for liver transplantation. However, the efficacy…2017 American Transplant Congress
The Role of Anti-Neu5Gc IgM in Xenograft Antibody Mediated Rejection.
Background:Acute antibody mediated rejection due to preformed antibodies present in human serum remains a hurdle to successful xenotransplantation. Here, we measured anti-Neu5Gc-IgM antibody titers in…2017 American Transplant Congress
Early Detection of Xenograft Rejection or Injury by Donor Derived Cell Free DNA in Pig to Baboon Cardiac Xenotransplantation.
Detection of early graft rejection (EGR) is a great deal in the field of transplantation (Tx). A number of biomarkers have been used to determine…
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