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American Transplant Congress abstracts

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Articles tagged "Xenotransplantation"

  • 2018 American Transplant Congress

    The Effect of Intravenous Immunoglobulin on In Vitro Human Antibody Binding to Genetically-Engineered Pig Cells – Relevance to Clinical Xenotransplantation –

    T. Yamamoto,1 Q. Li,1 H. Iwase,1 D. Ayares,2 D. Cooper,1 H. Hara.1

    1Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham; 2Revivicor, Blacksburg.

    Background: Xenoreactive antibodies play an important role in xenograft rejection. Intravenous immunoglobulin (IVIG), which has anti-complement activity and contains anti-idiotypic antibodies, is widely used for…
  • 2018 American Transplant Congress

    Successful Patency in Blood Conduits for an Artificial Kidney Membrane with Biocompatible Coatings

    R. Forbes,1 E. Marsh,1 S. Karp,1 A. Buck,1 D. Colvin,1 P. Williams,1 B. Chaudhuri,2 S. Roy,2 W. Fissell.1

    1VUMC, Nashville; 2UCSF, San Francisco.

    BACKGROUND: An implantable artificial kidney may address the growing organ shortage and improve outcomes and quality of life for those with end stage renal disease.…
  • 2018 American Transplant Congress

    An Effective Tolerance Approach for Porcine Islet Xenotransplantation in Humanized Mice

    F. Lee,1 A. Dangi,1 M. Burnette,1 X. Zhang,1 B. Hering,2 X. Luo.1

    1Comprehensive Transplant Center, Northwestern University, Chicago, IL; 2Diabetes/Endocrinology, Diabetes Institute, Minneapolis, MN.

    Purpose: Tolerance for pig-to-human islet transplantation could render a feasible and sustainable cure for T1D. We have previously described a triple therapy (TT) approach consisting…
  • 2018 American Transplant Congress

    Experience in the Development of a Life-Supporting Large Animal Orthotopic Cardiac Xenotransplant Model

    L. DiChiacchio,1 A. Singh,1 B. Lewis,1 E. Strauss,1 P. Odonkor,1 B. Williams,1 D. Ayares,2 K. Deatrick,1 Z. Kon,1 M. Mohiuddin.1

    1Cardiac Surgery, University of Maryland Medical Center, Baltimore, MD; 2Chief Scientific Office, Revivicor, Inc., Blacksburg, VA.

    Advances in clinical immunosuppression and characterization of optimal donor genetics continue to move the field of xenotransplantation toward a clinical reality with extremely long-term survival…
  • 2018 American Transplant Congress

    The Role of CD46 in Early Islet Engraftment in a Dual Transplant Model

    Q. Gao, K. Samy, R. Davis, M. Song, A. MacDonald, F. Leopardi, T. How, K. Williams, G. Devi, B. Collins, A. Kirk.

    Department of Surgery, Duke University School of Medicine, Durham, NC.

    IntroductionMembrane cofactor protein (CD46) is known to attenuate the complement cascade by facilitating cleavage of C3b and C4b. In solid organ xenotransplantation, organs expressing CD46…
  • 2018 American Transplant Congress

    Parathyroid Cell Xenotransplantation with Ultrapure Alginate Based Microencapsulation Technique

    B. Goncu,1 E. Yucesan,2 H. Basoglu,3 M. Celikten,1 O. Huseyinbas,1 B. Ozdemir,1 N. Ozten Kandas,4 F. Akbas,5 Y. Ersoy,6 E. Aysan.6

    1Bezmialem Vakif University, Experimental Research Center, Istanbul, Turkey; 2Bezmialem Vakif University, Institute of Life Sciences and Biotechnology, Istanbul, Turkey; 3Bezmialem Vakif University, Faculty of Medicine, Department of Biophysics, Istanbul, Turkey; 4Bezmialem Vakif University, Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Istanbul, Turkey; 5Bezmialem Vakif University, Faculty of Medicine, Department of Medical Biology, Istanbul, Turkey; 6Bezmialem Vakif University, Faculty of Medicine, Department of General Surgery, Istanbul, Turkey.

    Permanent hypoparathyroidism (PH) is a serious clinical condition and unique treatment option is parathyroid allotransplantation (PA). The most important obstacle for PA is an immune…
  • 2018 American Transplant Congress

    Prevention of an Adaptive Immune Response by FDA-Approved Immunosuppressive Agents in Baboons with Pig Artery Patch Xenografts

    T. Yamamoto,1 H. Hara,1 L. Wang,1 Q. Li,1 J. Li,1 H. Zhou,1 D. Eckhoff,1 A. Tector,1 D. Ayares,2 D. Cooper,1 H. Iwase.1

    1Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham; 2Revivicor, Blacksburg.

    Background: In the pig-to-baboon artery patch model with no immunosuppressive therapy, a graft from a GTKO pig elicits a significant anti-nonGal IgG response, indicating sensitization…
  • 2018 American Transplant Congress

    Effects of Preformed Antibody on Survival Following Pig-to-Primate Liver Xenotransplantation

    N. Louras, M. Patel, J. Shah, A. Andrews, Z. Wang, D. Sachs, P. Vagefi.

    Transplant Surgery, Massachusetts General Hospital, Boston, MA.

    Objectives:Xenotransplantation represents the best near-term solution to address the current organ shortage. We have developed a pre-clinical model of pig-to-primate liver xenotransplantation (LXT), and now…
  • 2018 American Transplant Congress

    Human Thrombomodulin Expression on Genetically Modified Donor Pigs is Required to Maintain the Anti-Coagulation Profile

    A. Singh, L. DiChiacchio, J. Chan, P. Corcoran, B. Lewis, M. Thomas, D. Ayares, K. Horvath, M. Mohiuddin.

    CSRP/NHLBI and DVR/ORS, NIH, Bethesda, MD; Revivicor Inc., Blacksburg, VA; Dept of Surgery, University of Maryland, Baltimore, MD.

    Introduction: Coagulation dysregulation is major limitation for xenotransplantation but it is resolved to some extent by making genetically engineered (GE) pigs, which express complement inhibitors…
  • 2018 American Transplant Congress

    hEPCR.hTBM.hCD47.HO-1 Contributes to Increased Survival, Reduced Platelet Sequestration, and Modulation of Coagulation Activation in GalTKO.hCD46 Porcine Livers Perfused with Human Blood

    A. Cimeno,1 L. Burdorf,1 D. Ayares,2 A. Azimzadeh,1 R. Pierson III,1 R. Barth,1 J. LaMattina.1

    1University of Maryland School of Medicine, Baltimore, MD; 2Revivicor, Inc., Baltimore, MD.

    IntroductionPlatelet sequestration and inappropriate coagulation cascade activation are associated with poor outcomes in multiple liver xenotransplant models. Here we evaluate a cassette of additional genetic…
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