2018 American Transplant Congress
Pancreas Decellularization Protocol – Comparison of Methods
Foundation of Research and Science Development, Otwock, Poland.
Background: Whole organ decellularization is gaining a lot of popularity since its development in tissue engineering. It is a process which allows to create complex…2018 American Transplant Congress
Biochemistry Profiles Following Pig-to-Nonhuman Primate Liver Xenotransplantation
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Objectives:Clinical progress in liver transplantation has increased the demand for organs, however, supply remains stagnant. Porcine liver xenotransplantation (LXT) would help address this imbalance. Here…2018 American Transplant Congress
Rhesus Monkey Have natural Antibody toward Swine That is Not Influenced by Allosensitization nor by Carfilzomib/tocilizumab
Surgery, Duke University, Durham, NC.
[Background] Pre-formed antibody is a substantial immunological barrier in organ transplantion. Antibodies to xenoantigens can lead to rapid antibody-mediated rejection (AMR) in xenotransplantation. We previously…2018 American Transplant Congress
Re-Endothelialization of Liver Xenografts Utilizing Human Endothelial Cells
1Surgery, University of Maryland, Baltimore, MD; 2Pathology, University of Maryland, Baltimore, MD.
Introduction:Acute antibody mediated rejection due to preformed antibodies present in human serum remains a hurdle to successful xenotransplantation. Xenograft vascular endothelium represents the initial site…2018 American Transplant Congress
The Effect of Intravenous Immunoglobulin on In Vitro Human Antibody Binding to Genetically-Engineered Pig Cells – Relevance to Clinical Xenotransplantation –
Background: Xenoreactive antibodies play an important role in xenograft rejection. Intravenous immunoglobulin (IVIG), which has anti-complement activity and contains anti-idiotypic antibodies, is widely used for…2018 American Transplant Congress
Successful Patency in Blood Conduits for an Artificial Kidney Membrane with Biocompatible Coatings
1VUMC, Nashville; 2UCSF, San Francisco.
BACKGROUND: An implantable artificial kidney may address the growing organ shortage and improve outcomes and quality of life for those with end stage renal disease.…2018 American Transplant Congress
An Effective Tolerance Approach for Porcine Islet Xenotransplantation in Humanized Mice
Purpose: Tolerance for pig-to-human islet transplantation could render a feasible and sustainable cure for T1D. We have previously described a triple therapy (TT) approach consisting…2018 American Transplant Congress
Experience in the Development of a Life-Supporting Large Animal Orthotopic Cardiac Xenotransplant Model
Advances in clinical immunosuppression and characterization of optimal donor genetics continue to move the field of xenotransplantation toward a clinical reality with extremely long-term survival…2018 American Transplant Congress
The Role of CD46 in Early Islet Engraftment in a Dual Transplant Model
Department of Surgery, Duke University School of Medicine, Durham, NC.
IntroductionMembrane cofactor protein (CD46) is known to attenuate the complement cascade by facilitating cleavage of C3b and C4b. In solid organ xenotransplantation, organs expressing CD46…2018 American Transplant Congress
Parathyroid Cell Xenotransplantation with Ultrapure Alginate Based Microencapsulation Technique
Permanent hypoparathyroidism (PH) is a serious clinical condition and unique treatment option is parathyroid allotransplantation (PA). The most important obstacle for PA is an immune…
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